SDC4

  • Official Full Name

    syndecan 4

  • Overview

    Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.
  • Synonyms

    SDC4; SYND4; syndecan 4; Syndecan 4; amphiglycan; ryudocan amphiglycan; ryudocan core protein; syndecan proteoglycan 4; syndecan 4 (amphiglycan, ryudocan);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Gallus gallus (Chicken)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SDC4-19H Active Recombinant Human SDC4, His-tagged Mammalian cells His
Human SDC4-505H Recombinant Human SDC4, Fc-tagged HEK293 Fc
Human SDC4-2425H Recombinant Human Syndecan 4, Fc Chimera Human Cell Fc
Human SDC4-18H Recombinant Human SDC4 protein E.coli N/A 127
Human SDC4-4631H Recombinant Syndecan 4 Human N/A
Human SDC4-301204H Recombinant Human SDC4 protein, GST-tagged E.coli GST Glu19-Glu145
Human SDC4-3947H Recombinant Human SDC4 protein, His-SUMO-tagged E.coli His-SUMO 19-145aa
Human SDC4-411H Recombinant Human SDC4 Protein (Met1-Glu145), His-tagged HEK293 His Met1-Glu145
Human SDC4-6251H Recombinant Human SDC4 Protein (Ala18-Glu145), N-His tagged E.coli N-His Ala18-Glu145
Human SDC4-4037H-B Recombinant Human SDC4 Protein Pre-coupled Magnetic Beads HEK293
Human SDC4-4037H Recombinant Human SDC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sdc4-963M Active Recombinant Mouse Sdc4 Protein, His-tagged Mammalian cells His Glu24-Val146
Mouse SDC4-2341M Recombinant Mouse SDC4 protein(Met1-Val146), hFc-tagged HEK293 C-hFc Met1-Val146
Mouse Sdc4-1993M Recombinant Mouse Sdc4 protein, His-tagged E.coli His Gly23~Glu145 (Accession # O35988)
Mouse SDC4-387M Recombinant Mouse Sdc4, Fc tagged Human Cell His
Mouse Sdc4-7017M Recombinant Mouse Sdc4 protein(Met1-Val146), His-tagged HEK293 C-His Met1-Val146
Mouse SDC4-1057MCL Recombinant Mouse SDC4 cell lysate Human Cell N/A
Mouse Sdc4-7959M Recombinant Mouse Sdc4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sdc4-6794M Recombinant Mouse Sdc4 Protein (Glu24-Glu145), C-His tagged Mammalian cells C-His Glu24-Glu145
Mouse Sdc4-7959M-B Recombinant Mouse Sdc4 Protein Pre-coupled Magnetic Beads HEK293
Rat Sdc4-1994R Recombinant Rat Sdc4 protein, His-tagged E.coli His Gly23~Glu149 (Accession # P34901)
Rat SDC4-5286R Recombinant Rat SDC4 Protein Mammalian Cell His
Rat SDC4-4945R Recombinant Rat SDC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SDC4-4945R-B Recombinant Rat SDC4 Protein Pre-coupled Magnetic Beads HEK293
Gallus gallus (Chicken) RFL25953GF Recombinant Full Length Chicken Syndecan-4(Sdc4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-197)
Mus musculus (Mouse) RFL15657MF Recombinant Full Length Mouse Syndecan-4(Sdc4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-198)
Rattus norvegicus (Rat) RFL16456RF Recombinant Full Length Rat Syndecan-4(Sdc4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-202)
Rhesus Macaque SDC4-4107R Recombinant Rhesus monkey SDC4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SDC4-3924R-B Recombinant Rhesus Macaque SDC4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SDC4-3924R Recombinant Rhesus Macaque SDC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SDC4-4449Z Recombinant Zebrafish SDC4 Mammalian Cell His
Chicken SDC4-1992C Recombinant Chicken SDC4 protein, His & T7-tagged E.coli His/T7 Glu20~Thr147 (Accession # P49416)
Chicken SDC4-1782C Recombinant Chicken SDC4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SDC4 involved in several pathways and played different roles in them. We selected most pathways SDC4 participated on our site, such as ECM-receptor interaction, Cell adhesion molecules (CAMs), Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionTHBS4;THBS3A;SDC1;FN1;ITGA8;COL4A2;COL6A5;CD44;LAMB4
Cell adhesion molecules (CAMs)NRXN3A;SPN;OCLNB;SELP;ITGB2;NADL1.2;MAG;MADCAM1;ITGA8
Proteoglycans in cancerAKT1;DROSHA;MAPK1;PXN;WNT4;PPP1R12A;MET;RAC1;ANK2

SDC4 has several biochemical functions, for example, fibronectin binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC4 itself. We selected most functions SDC4 had, and list some proteins which have the same functions with SDC4. You can find most of the proteins on our site.

Function Related Protein
fibronectin bindingIGFBP5A;ITGB1;SDC4;MFAP2;IGFBP5;LPA;FBLN1;PLEKHA2;FSTL3
protein bindingSNRPG;HLA-DRB3;NUDT21;LGI4;B2M;TP53INP1;PRKCQ;TIPRL;MYF5
protein kinase C bindingC1QBP;ADD3;HDAC7A;AKT2;YWHAG;PEA15A;TIRAP;PRKCSH;HAND2
thrombospondin receptor activityCD47;SDC4;F2

SDC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC4.

SGTA; PRKCA; GIPC1; PECAM1; TGFB3; TANK; DBN1; Lima1

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