SDCBP
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Official Full Name
syndecan binding protein (syntenin) -
Overview
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the;cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal;domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell;adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to;membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus.;Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
SDCBP;syndecan binding protein (syntenin);syntenin-1;SYCL;scaffold protein Pbp1;syndecan-binding protein 1;melanoma differentiation associated protein-9;melanoma differentiation-associated protein 9;pro-TGF-alpha cytoplasmic domain-interacting pro
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- DDK
- Myc
- Fc
- Flag
- GST
- Avi
- KSI
Involved Pathway
SDCBP involved in several pathways and played different roles in them. We selected most pathways SDCBP participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDCBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | SPRED3,PPP3CC,JAK2,UNC5D,ROCK1,GDNF,COL6A3,PAK2,RND1,GSK3B |
| IL-5 Signaling Pathway | ALOX5AP,GSK3AB,UNC119 |
| Neurofascin interactions | CNTN1,DCX |
| Syndecan-1-mediated signaling events | PPIB |
| Developmental Biology | BNIP2,SPRED2,DNM2,FOXH1,KALRN,EFNA3,EFNA4,DLG3,NR5A1,NTN1B |
| L1CAM interactions | KCNQ3,DCX,EZRA,NRP2,NADL1.1,DPYSL2B,SCN9A,CD24,KIF4A,CHL1 |
| EPH-Ephrin signaling | AP2A2,ARPC5,KDR,EFNA1B,EPHA10,EFNA3B,EFNB3,DNM1,EPHB4A,AP2M1 |
| Ephrin signaling | EPHB3A,EPHB4A,EFNB2A,EFNB3B,MYL12A,EFNB1,EFNB3,EPHB4B,EFNB2 |
Protein Function
SDCBP has several biochemical functions, for example, cell adhesion molecule binding,cytoskeletal adaptor activity,ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDCBP itself. We selected most functions SDCBP had, and list some proteins which have the same functions with SDCBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPL13,MEN1,SLC3A2,IRF2BP1,MMRN2,PRAP1,ACTL6A,NASP,TRPV5,GALR2 |
| protein N-terminus binding | LACRT,TBL1XR1,APTX,UNC13A,ARF6,CSNK2A2,ALOX5AP,MORF4L1,PEX14,PEX5 |
| glycoprotein binding | CANX,Itgam&Itgb2,ITGAM,B2M,LMAN2,FBXO27,RAB14,PIP,FYN,FBXO6 |
| growth factor binding | GHR,LTBP2,HTRA1B,ERBB3,OSMR,RPL37,LTBP4,FLT1,FLT4,IL6ST |
| neurexin family protein binding | NLGN4Y,LRRTM2,NLGN1,SYTL2,CPE,NLGN3A,NLGN4A,NLGN2A,SYTL1,NLGN4X |
| cell adhesion molecule binding | DSG2,PVRL2L,PVRL1A,PVRL4,PVR,CD1D,CADM2,PVRL1B,Fert2,CD200 |
| frizzled binding | WNT6,DVL1,WNT10B,CTHRC1,WNT2BA,DVL2,WNT7B,WNT8B,WNT7A,WNT9A |
| protein C-terminus binding | VPS4B,HPCAL4,CLIC6,KSR1,XRCC6,VGLL1,ATP2A2,HIC2,MLLT4,AXIN1 |
| protein heterodimerization activity | KCNN1,HMG20B,VEGFB,HOMER2,NR2C2,HIST1H2BP,HER5,CYBB,H3F3B.1,NTSR1 |
Interacting Protein
SDCBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDCBP here. Most of them are supplied by our site. Hope this information will be useful for your research of SDCBP.
FZD7;a0a024ra76_human;CCDC102B;ERICH2;CADPS;CEP55
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