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SLPI

  • Official Full Name

    secretory leukocyte peptidase inhibitor

  • Overview

    This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008]
  • Synonyms

    SLPI; secretory leukocyte peptidase inhibitor; ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I; antileukoproteinase; HUSI-1; protease inhibitor WAP4; mucus proteinase inhibitor; seminal proteinase inhibitor; WAP four-disulfide core domain protein 4; secretory leukocyte protease inhibitor (antileukoproteinase);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • hFc
  • Flag
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLPI-2550H Active Recombinant Human SLPI protein, His-tagged Insect Cell His Met1-Ala132
Human SLPI-5643H Recombinant Human SLPI protein, hFc-tagged HEK293 C-hFc Ser26-Ala132
Human SLPI-30969TH Recombinant Human SLPI, His-tagged E.coli His 107 amino acids
Human SLPI-2575H Recombinant Human Secretory Leukocyte Peptidase Inhibitor, His-tagged E.coli His
Human SLPI-2551H Recombinant Human SLPI, His tagged Insect Cell His Ser26-Ala132
Human SLPI-530HCL Recombinant Human SLPI cell lysate Insect Cell Non
Human SLPI-001HCL Recombinant Human SLPI cell lysate Insect Cell Non
Human SLPI-2349H Recombinant Human SLPI Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc&DDK
Human SLPI-2036H-B Recombinant Human SLPI Protein Pre-coupled Magnetic Beads HEK293
Human SLPI-6313H Recombinant Human SLPI Protein (Ser26-Ala132), N-GST tagged E.coli GST Ser26-Ala132
Human SLPI-2704H Recombinant Human SLPI Protein, His-tagged E.coli His Ser26-Ala132
Human SLPI-950HFL Recombinant Full Length Human SLPI Protein, C-Flag-tagged Mammalian cells Flag
Human SLPI-2036H Recombinant Human SLPI Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human SLPI-3504H Recombinant Human SLPI protein, His&Myc-tagged E.coli His&Myc 26-132aa
Mouse SLPI-15575M Recombinant Mouse Slpi protein, His-tagged E.coli His Pro20~Met131
Mouse Slpi-3516M Recombinant Mouse Slpi, His-tagged E.Coli or Yeast His 131
Mouse Slpi-5945M Recombinant Mouse Slpi Protein, Myc/DDK-tagged HEK293T Myc&DDK
Mouse Slpi-5644M Recombinant Mouse Slpi protein, hFc-tagged HEK293 C-hFc Ser26-Met131
Rat Slpi-2082R Recombinant Rat Slpi Protein, His&GST-tagged E.coli His&GST Gly26-Val130
Rhesus Macaque SLPI-4326R Recombinant Rhesus monkey SLPI Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLPI-4142R Recombinant Rhesus Macaque SLPI Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rhesus Macaque SLPI-4142R-B Recombinant Rhesus Macaque SLPI Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SLPI involved in several pathways and played different roles in them. We selected most pathways SLPI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLPI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SLPI has several biochemical functions, for example, endopeptidase inhibitor activity, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLPI itself. We selected most functions SLPI had, and list some proteins which have the same functions with SLPI. You can find most of the proteins on our site.

Function Related Protein
endopeptidase inhibitor activityPI3;SERPINA1D;C3B.2;A1i3;C3P1;MUG2;C3;CAST;A2ML
enzyme bindingUSF1;CSF3;CTNNBL1;BACE1;HDAC2;PARP4;PTPLA;FOXO4;DAXX
protein bindingSFN;ZNF212;CREB3L3;GOLGA3;C16orf48;DVL1;FBN2;MATK;B2M
serine-type endopeptidase inhibitor activityITIH1;CD109;SERPINB7;WFDC6B;APPB;SERPINB2;SERPINB6;ITIH2;SERPINB1

SLPI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLPI here. Most of them are supplied by our site. Hope this information will be useful for your research of SLPI.

SGTA; FAM9B; ELANE; NFKBIB; MAPK8IP2

Research Area

Related articles

Hirbod, T; Kong, XR; et al. HIV Acquisition Is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men. PLOS PATHOGENS 10:-(2014).
Woodham, AW; Da Silva, DM; et al. The S100A10 Subunit of the Annexin A2 Heterotetramer Facilitates L2-Mediated Human Papillomavirus Infection. PLOS ONE 7:-(2012).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
12/06/2022

    the SLPI protein is highly regarded for its excellent performance in WB assays and its significant contribution to protein EM structure analysis.

    02/27/2021

      The SLPI protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.

      10/25/2016

        Its reliability and high quality make it a valuable tool in various applications, ranging from enzymatic assays to studying protein-protein interactions.

        Q&As (5)

        Ask a question
        Are there any side effects associated with the use of SLPI protein in clinical applications? 12/15/2022

        The potential side effects of SLPI supplementation or therapy have not been extensively studied and would require further investigation.

        Are there any clinical trials using SLPI protein for the treatment of inflammatory conditions? 07/21/2022

        Several clinical trials have investigated the use of SLPI in conditions such as chronic obstructive pulmonary disease (COPD) and inflammatory bowel disease (IBD).

        Are there any diagnostic applications of SLPI protein? 02/08/2019

        SLPI levels in biological fluids, such as saliva and sputum, have been studied as potential biomarkers for various diseases and conditions.

        How does SLPI protein affect inflammation? 07/28/2017

        SLPI has anti-inflammatory properties and can inhibit the activity of various proteases involved in the inflammatory response.

        How is SLPI protein being studied in the context of HIV/AIDS? 01/07/2017

        SLPI has been investigated as a potential therapeutic agent for HIV/AIDS, as it may inhibit viral replication and transmission.

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