SMAD6

  • Official Full Name

    SMAD family member 6

  • Overview

    The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

  • Synonyms

    SMAD6;SMAD family member 6;AOVD2;MADH6;MADH7;HsT17432;mothers against decapentaplegic homolog 6;SMAD 6;hSMAD6;MAD homolog 6;mothers against DPP homolog 6;SMAD, mothers against DPP homolog 6;Mothers against decapentaplegic, drosophila, homolog of, 6

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • E. coli
  • His
  • Non
  • DDK
  • Myc
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SMAD6-2801H Recombinant Human SMAD6, His-tagged E.coli Human His 1-496aa
SMAD6-15589M Recombinant Mouse SMAD6 Protein Mammalian Cells Mouse His
SMAD6-4113Z Recombinant Zebrafish SMAD6 Mammalian Cells Zebrafish His
SMAD6-5821C Recombinant Chicken SMAD6 Mammalian Cells Chicken His
SMAD6-1644HCL Recombinant Human SMAD6 cell lysate Human Non
PGC-299H Recombinant Human SMAD6 Protein, His-tagged E.coli Human His Cys261~Pro495
SMAD6-1913H Recombinant Human SMAD6 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
SMAD6-2257H Recombinant Human SMAD6 protein, His&Myc-tagged Insect Cells Human His&Myc 1-496aa
SMAD6-22H Recombinant Human SMAD6 Protein, GST-tagged Wheat Germ Human GST
Smad6-300M Recombinant Mouse Smad6 Protein, His-tagged E.coli Mouse His Pro116~Gly364
Smad6-301R Recombinant Rat Smad6 Protein, His-tagged E.coli Rat His Gln171~Asp441
SMAD6-3507H Recombinant Human SMAD6 protein, His&Myc-tagged E.coli Human His&Myc 1-496aa
SMAD6-5065H Recombinant Human SMAD6 protein, His&Myc-tagged HEK293 Human His&Myc 1-496aa
Smad6-5953M Recombinant Mouse Smad6 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
SMAD6-6773HF Recombinant Full Length Human SMAD6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 496 amino acids
SMAD6-7874H Recombinant Human SMAD6 protein, His-tagged E. coli Human His
SMAD6-8458M Recombinant Mouse SMAD6 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SMAD6-8458M-B Recombinant Mouse SMAD6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway INHBAB,BMPR2A,CUL1B,RHOAA,BMPR2B,TGFBR1A,NDR1,RPS6KB1,ID2,INHBA

    Protein Function

    SMAD6 has several biochemical functions, for example, I-SMAD binding,R-SMAD binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding ZFP518A,CTBP1,PRDM1,ETV1,MYCL1,CNBP,NFIX,HOXD4A,NR1D2A,PHF1
    transcription regulatory region DNA binding GRHL2B,ATF4,NR1H3,FOXC2,XRCC6,NKX3,GFI1,ZFP513,MZF1,MEN1
    R-SMAD binding SMAD4,PARP1,PAX6,ZC3H3,FOS,SMAD2,MYOCD,CTNNB1,C18orf1,PMEPA1
    identical protein binding COL18A1,SLC22A1,SMG9,BNIP3,HCN2,GBP5,CLDN9,CLDN16,LYZ,UBE4A
    type I activin receptor binding NODAL,NDR2,SPAW,NDR1
    ubiquitin protein ligase binding TCEB2,GSK3B,MAGEA2,RPA2,DAXX,SCN5A,FZD5,PINK1,NKD2,GGN
    chromatin binding HDAC7,SMC1A,FANCM,UBE2T,DNMT3B,HOXD10,LOXL2,RNF20,SOX9,POLD1
    I-SMAD binding SMAD2,SMAD1,CTNNB1,TGFB1I1,AXIN1,AXIN2,TGFBR1,SMAD7,SMAD4,SMURF1
    protein binding XPO7,LXN,GGA2,CDC26,CCNE1,NETO2,OTX2,CASP6,SOX30,HARS2

    Interacting Protein

    SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.

    PRKX;SMAD1;Runx2;RUNX2;UBE2O;RPS6KA5;FKBP1A;MAPK6;SMURF2

    SMAD6 Related Signal Pathway

    Resources

    References

    • Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).
    • Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).

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