SMAD6
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Official Full Name
SMAD family member 6
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Background
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009] -
Synonyms
SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6;
- Involved Pathway
- Protein Function
- Interacting Protein
- SMAD6 Related Articles
- SMAD6 Related Signal Pathway
SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | LFT1;PITX2;RPS6KB2;MAPK1;MAPK3;TGFB3;ID4;TGFBR1A;BMPR1BB |
SMAD6 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| I-SMAD binding | TGFB1I1;SMAD6;SMAD4;CTNNB1;SMURF1;SMAD1;AXIN1;TGFBR1;AXIN2 |
| R-SMAD binding | PMEPA1;SMAD3;JUN;ZC3H3;SMAD2;ANKRD1;ZEB2;MEN1;PAX6 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CEBPZ;BATF2;NKX3-2;ZFP639;CEBPE;PBX1;HLTF;JUNB;SNAI3 |
| chromatin binding | HDAC3;KIAA0101;APTX;KAT2A;PBRM1L;MSGN1;GATA6;UBTF;MED1 |
| co-SMAD binding | TRIM33;FOXH1;SMAD2;SMAD1;SMAD3;SMAD6;TGIF1;USP9X;GATA4 |
| identical protein binding | CCL4;ATL2;C1QTNF2;CLDN17;BAK1;NEFL;LYZ1;HGF;RYR2 |
| metal ion binding | KDM3B;DROSHA;COX5B;GLRX5;RBM22;MB;METAP1D;SIAH1A;ACSM2B |
| protein binding | MPP2;CCR1;SIRT3;MICALL1;IMPA1;AEN;BANF1;NASP;GTF2E1 |
| transcription factor activity, sequence-specific DNA binding | AHR;LBX1;FOXA1;CEBP1;TFAP2B;FOXD1;UBN1;FLI1B;TFDP2 |
| transcription regulatory region DNA binding | FOXA1;SALL1A;RBBP5;CTNNB1;Arid4b;SMAD3;RFX6;TRP53;TAF7 |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | SMAD6;SMAD7 |
| type I activin receptor binding | NDR1;SPAW;SMAD6;NODAL;NDR2 |
| type I transforming growth factor beta receptor binding | SNX25;TGFB1;SMAD2;SMAD6;FKBP1A;ENG;TGFBR2;TGFB3;SMAD7 |
| ubiquitin protein ligase binding | RPA3;TRIM37;RANGAP1;WASH1;CASC3;POLR2A;ZFP746;UBE2G1A;EGFR |
SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.
PRKX; SMAD1; Runx2; RUNX2; UBE2O; RPS6KA5; FKBP1A; MAPK6; SMURF2
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