SMAD6

  • Official Full Name

    SMAD family member 6

  • Overview

    The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
  • Synonyms

    SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD6-2801H Recombinant Human SMAD6, His-tagged E.coli His 1-496aa
Human SMAD6-1644HCL Recombinant Human SMAD6 cell lysate N/A
Human SMAD6-1913H Recombinant Human SMAD6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SMAD6-22H Recombinant Human SMAD6 Protein, GST-tagged Wheat Germ GST
Human SMAD6-2257H Recombinant Human SMAD6 protein, His&Myc-tagged Insect Cell His&Myc 1-496aa
Human PGC-299H Recombinant Human SMAD6 Protein, His-tagged E.coli His Cys261~Pro495
Human SMAD6-3507H Recombinant Human SMAD6 protein, His&Myc-tagged E.coli His&Myc 1-496aa
Human SMAD6-5065H Recombinant Human SMAD6 protein, His&Myc-tagged HEK293 His&Myc 1-496aa
Human SMAD6-6773HF Recombinant Full Length Human SMAD6 Protein, GST-tagged In Vitro Cell Free System GST 496 amino acids
Mouse SMAD6-15589M Recombinant Mouse SMAD6 Protein Mammalian Cell His
Mouse Smad6-300M Recombinant Mouse Smad6 Protein, His-tagged E.coli His Pro116~Gly364
Mouse Smad6-5953M Recombinant Mouse Smad6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SMAD6-8458M Recombinant Mouse SMAD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMAD6-8458M-B Recombinant Mouse SMAD6 Protein Pre-coupled Magnetic Beads HEK293
Rat Smad6-301R Recombinant Rat Smad6 Protein, His-tagged E.coli His Gln171~Asp441
Zebrafish SMAD6-4113Z Recombinant Zebrafish SMAD6 Mammalian Cell His
Chicken SMAD6-5821C Recombinant Chicken SMAD6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SMAD6 Related Signal Pathway

SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayACVR1BA;PITX2;LEFTY2;ID2;SMAD5;SMAD1;IFNG1-2;BMPR1AA;GDF5

SMAD6 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.

Function Related Protein
I-SMAD bindingSMURF1;SMAD2;SMAD7;TGFB1I1;TGFBR1;SMAD1;AXIN2;AXIN1;SMAD6
R-SMAD bindingAXIN1;MEN1;ANKRD1;CTNNB1;JUN;PPM1A;SMURF1;SMAD6;SMAD3
RNA polymerase II core promoter proximal region sequence-specific DNA bindingHLTF;AGO1;H2AFZ;NR4A3;SIX5;MYBL1;ZNF680;PITX2;NFIC
chromatin bindingPOLD1;LOXL2;EBF2;EGFR;ZEB1;SOX10;DNMT3A;HMGB2B;JARID2B
co-SMAD bindingTRIM33;SMAD1;SMAD3;GATA4;SMAD6;USP9X;CITED1;TGIF1;FOXH1
identical protein bindingADORA2A;TNF;TRIM5;COL7A1;GDF5;SH2B2;HCN2;NDC80;PTK6
metal ion bindingHDAC7;AOX3;FYCO1;NT5C3L;PPAT;ZFP2;ACSM4;ZFP513;ESCO1
protein bindingSMAD3;ARHGAP5;PSMF1;RRAGB;C17orf28;CPNE3;IK;NATD1;GGA2
transcription factor activity, sequence-specific DNA bindingHOXA6;MZF1;FOXG1C;Trl;HEYL;FEV;ZNF565;RXRBB;SLC30A9
transcription regulatory region DNA bindingFOXA1;ZFP821;KCNA3;ZNF174;GATA5;SOX6;SIX1;PAX2;RFX6
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activitySMAD6;SMAD7
type I activin receptor bindingNDR2;SMAD6;NDR1;NODAL;SPAW
type I transforming growth factor beta receptor bindingTGFBR2;SNX25;TGFB3;SMAD6;TGFB1;ENG;SMAD7;FKBP1A;SMAD2
ubiquitin protein ligase bindingAURKA;TUBA1B;NPLOC4;PRDX6;NDUFS2;BAG4;RALB;DBT;HM13

SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.

PRKX; SMAD1; Runx2; RUNX2; UBE2O; RPS6KA5; FKBP1A; MAPK6; SMURF2

Research Area

Related articles

Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).
Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).
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