SMAD6 Protein


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Official Full Name SMAD family member 6
Background The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
Synonyms SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • His&Myc
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD6-2801H Recombinant Human SMAD6, His-tagged E.coli His Inquiry
    Mouse SMAD6-15589M Recombinant Mouse SMAD6 Protein Mammalian Cell His Inquiry
    Chicken SMAD6-5821C Recombinant Chicken SMAD6 Mammalian Cell His Inquiry
    Zebrafish SMAD6-4113Z Recombinant Zebrafish SMAD6 Mammalian Cell His Inquiry
    Human SMAD6-1644HCL Recombinant Human SMAD6 cell lysate N/A Inquiry
    Human SMAD6-2257H Recombinant Human SMAD6 protein, His&Myc-tagged Insect Cell His&Myc Inquiry
    Human SMAD6-3507H Recombinant Human SMAD6 protein, His&Myc-tagged E.coli His&Myc Inquiry
    Human SMAD6-5065H Recombinant Human SMAD6 protein, His&Myc-tagged HEK293 His&Myc Inquiry
    Human SMAD6-6773HF Recombinant Full Length Human SMAD6 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Mouse SMAD6-8458M Recombinant Mouse SMAD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human PGC-299H Recombinant Human SMAD6 Protein, His-tagged E.coli His Inquiry
    Human SMAD6-1913H Recombinant Human SMAD6 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human SMAD6-22H Recombinant Human SMAD6 Protein, GST-tagged Wheat Germ GST Inquiry
    Mouse Smad6-300M Recombinant Mouse Smad6 Protein, His-tagged E.coli His Inquiry
    Mouse Smad6-5953M Recombinant Mouse Smad6 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Rat Smad6-301R Recombinant Rat Smad6 Protein, His-tagged E.coli His Inquiry

    SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway LEFTY1; RHOA; BMPR2A; TGFB1A; BMPR1B; ID1; BMP5; BAMBIB; BMP8A; TGFBR1

    SMAD6 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.

    Function Related Protein
    R-SMAD binding TRIM33; PARP1; C18orf1; PPM1A; RANBP3; SMURF1; JUN; ANKRD1; SMAD6; ZEB2
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SPI1; NRF1; FOXI1; MESP1; FUBP3; PDX1; SIX2; RAX; MYOD1; MSX2
    chromatin binding PBRM1; PRKAA2; HDAC3; LMO2; SLC30A9; FOXN4; TCF7L1A; CENPB; PRDM11; MSH6
    co-SMAD binding GATA4; TGIF1; SMAD1; CITED1; FOXH1; SMAD3; SMAD2; USP9X; TRIM33; SMAD6
    identical protein binding NDE1; HOOK1; TRADD; BCHE; DPP4; HOOK2; MCM6; MPST; VAMP2; ACADM
    metal ion binding PPARAA; HDDC3; NUDT14; FKBP8; WBP7; PEG3; HDAC7A; PRKCHB; NR5A1B; SAP30L
    protein binding DOLK; NFKB1; HPCAL4; RGL2; CALCOCO2; CNOT2; PRRC1; UBE2U; SNRPF; Fzd4
    transcription factor activity, sequence-specific DNA binding ZNF493; RORA; PRRX2; FOXN4; PIP4K2AA; ZHX3; TFE3; TRIM29; OTX1A; TAL1
    transcription regulatory region DNA binding HHEX; RNF10; TAF9; CITED1; KLF17; IKZF1; HIVEP2; ARID4A; ZNF613; FOXC1
    transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity SMAD6; SMAD7
    type I activin receptor binding NODAL; SMAD6; NDR1; SPAW; NDR2
    type I transforming growth factor beta receptor binding SMAD7; ENG; TGFB3; SMAD6; FKBP1A; TGFB1; SNX25; SMAD2; TGFBR2
    ubiquitin protein ligase binding UBE2V1; HIF1A; STUB1; ASB4; IKBKG; Fzd4; PACRG; RB1; TRAF5; NEDD8

    SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.


    Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).
    Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).

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