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SMAD6

Official Full Name

SMAD family member 6
Overview

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
Synonyms

SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SMAD6-2801H	Recombinant Human SMAD6, His-tagged	E.coli	His	1-496aa	$319 / 25ug
Human	SMAD6-1644HCL	Recombinant Human SMAD6 cell lysate		N/A		Inquiry
Human	SMAD6-1913H	Recombinant Human SMAD6 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SMAD6-22H	Recombinant Human SMAD6 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	SMAD6-2257H	Recombinant Human SMAD6 protein, His&Myc-tagged	Insect Cell	His&Myc	1-496aa	Inquiry
Human	PGC-299H	Recombinant Human SMAD6 Protein, His-tagged	E.coli	His	Cys261~Pro495	Inquiry
Human	SMAD6-3507H	Recombinant Human SMAD6 protein, His&Myc-tagged	E.coli	His&Myc	1-496aa	Inquiry
Human	SMAD6-5065H	Recombinant Human SMAD6 protein, His&Myc-tagged	HEK293	His&Myc	1-496aa	Inquiry
Human	SMAD6-6773HF	Recombinant Full Length Human SMAD6 Protein, GST-tagged	In Vitro Cell Free System	GST	496 amino acids	Inquiry
Mouse	SMAD6-15589M	Recombinant Mouse SMAD6 Protein	Mammalian Cell	His		Inquiry
Mouse	Smad6-300M	Recombinant Mouse Smad6 Protein, His-tagged	E.coli	His	Pro116~Gly364	Inquiry
Mouse	Smad6-5953M	Recombinant Mouse Smad6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SMAD6-8458M	Recombinant Mouse SMAD6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SMAD6-8458M-B	Recombinant Mouse SMAD6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Smad6-301R	Recombinant Rat Smad6 Protein, His-tagged	E.coli	His	Gln171~Asp441	Inquiry
Zebrafish	SMAD6-4113Z	Recombinant Zebrafish SMAD6	Mammalian Cell	His		Inquiry
Chicken	SMAD6-5821C	Recombinant Chicken SMAD6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
SMAD6 Related Signal Pathway

SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	ACVR1BA;PITX2;LEFTY2;ID2;SMAD5;SMAD1;IFNG1-2;BMPR1AA;GDF5

SMAD6 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.

Function	Related Protein
I-SMAD binding	SMURF1;SMAD2;SMAD7;TGFB1I1;TGFBR1;SMAD1;AXIN2;AXIN1;SMAD6
R-SMAD binding	AXIN1;MEN1;ANKRD1;CTNNB1;JUN;PPM1A;SMURF1;SMAD6;SMAD3
RNA polymerase II core promoter proximal region sequence-specific DNA binding	HLTF;AGO1;H2AFZ;NR4A3;SIX5;MYBL1;ZNF680;PITX2;NFIC
chromatin binding	POLD1;LOXL2;EBF2;EGFR;ZEB1;SOX10;DNMT3A;HMGB2B;JARID2B
co-SMAD binding	TRIM33;SMAD1;SMAD3;GATA4;SMAD6;USP9X;CITED1;TGIF1;FOXH1
identical protein binding	ADORA2A;TNF;TRIM5;COL7A1;GDF5;SH2B2;HCN2;NDC80;PTK6
metal ion binding	HDAC7;AOX3;FYCO1;NT5C3L;PPAT;ZFP2;ACSM4;ZFP513;ESCO1
protein binding	SMAD3;ARHGAP5;PSMF1;RRAGB;C17orf28;CPNE3;IK;NATD1;GGA2
transcription factor activity, sequence-specific DNA binding	HOXA6;MZF1;FOXG1C;Trl;HEYL;FEV;ZNF565;RXRBB;SLC30A9
transcription regulatory region DNA binding	FOXA1;ZFP821;KCNA3;ZNF174;GATA5;SOX6;SIX1;PAX2;RFX6
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	SMAD6;SMAD7
type I activin receptor binding	NDR2;SMAD6;NDR1;NODAL;SPAW
type I transforming growth factor beta receptor binding	TGFBR2;SNX25;TGFB3;SMAD6;TGFB1;ENG;SMAD7;FKBP1A;SMAD2
ubiquitin protein ligase binding	AURKA;TUBA1B;NPLOC4;PRDX6;NDUFS2;BAG4;RALB;DBT;HM13

SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.

PRKX; SMAD1; Runx2; RUNX2; UBE2O; RPS6KA5; FKBP1A; MAPK6; SMURF2

Research Area

Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).

Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).