Recombinant Human SMAD6 Protein, GST-tagged

• Cat.No.: SMAD6-22H
• Product Overview: Human SMAD6 full-length ORF (AAH12986.1, 1 a.a. - 496 a.a.) recombinant protein with GST tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.96 kDa
• AA Sequence: MFRSKRSGLVRRLWRSRVVPDREEG GSGGGGGGDEDGSLGSRAEPAPRAR EGGGCGRSEVRPVAPRRPRDAVGQR GAQGAGRRRRAGGPPRPMSEPGAGA GSSLLDVAEPGGPGWLPESDCETVT CCLFSERDAAGAPRDASDPLAGAAL EPAGGGRSREARSRLLLLEQELKTV TYSLLKRLKERSLDTLLEAVESRGG VPGGCVLVPRADLRLGGQPAPPQLL LGRLFRWPDLQHAVELKPLCGCHSF AAAADGPTVCCNPYHFSRLCGPESP PPPYSRLSPRDEYKPLDLSDSTLSY TETEATNSLITAPGEFSDASMSPDA TKPSHWCSVAYWEHRTRVGRLYAVY DQAVSIFYDLPQGSGFCLGQLNLEQ RSESVRRTRSKIGFGILLSKEPDGV WAYNRGEHPIFVNSPTLDAPGGRAL VVRKVPPGYSIKVFDFERSGLQHAP EPDAADGPYDPNSVRISFAKGWGPC YSRQFITSCPCWLEILLNNPR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: SMAD6 SMAD family member 6 [ Homo sapiens (human) ]
• Official Symbol: SMAD6
• Synonyms: SMAD6; SMAD family member 6; AOVD2; MADH6; MADH7; HsT17432; mothers against decapentaplegic homolog 6; MAD homolog 6; SMAD, mothers against DPP homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6
• Gene ID: 4091
• mRNA Refseq: NM_005585
• Protein Refseq: NP_005576
• MIM: 602931
• UniProt ID: O43541