Recombinant Mouse Smad6 Protein, Myc/DDK-tagged

Cat.No. : Smad6-5953M
Product Overview : Purified recombinant protein of mouse full-length SMAD family member 6 (Smad6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Binds to regulatory elements in target promoter regions. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 54.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Smad6 SMAD family member 6 [ Mus musculus (house mouse) ]
Official Symbol : Smad6
Synonyms : SMAD6; MAD homolog 6 (Drosophila); mothers against decapentaplegic homolog 6; Smad 6; mad homolog 7; SMAD family member 6; mothers against DPP homolog 6; Madh6
Gene ID : 17130
mRNA Refseq : NM_008542
Protein Refseq : NP_032568
UniProt ID : O35182

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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