SPR
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Official Full Name
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
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Overview
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. -
Synonyms
SPR; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); sepiapterin reductase; SDR38C1; short chain dehydrogenase/reductase family 38C; member 1; OTTHUMP00000160199; short chain dehydrogenase/reductase family 38C, member 1; SPRE_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- N
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SPR involved in several pathways and played different roles in them. We selected most pathways SPR participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | PTS;FPGS;DHFR;DHFRL1;ALPI;ALPL;QDPRB2;QDPRA;SPR |
| Metabolic pathways | QDPRB1;MTMR3;DNMT3AB;PFKMB;CBR1L;ATP6V1E2;P4HA1;SEPHS2;PKLR |
SPR has several biochemical functions, for example, NADP binding, aldo-keto reductase (NADP) activity, sepiapterin reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPR itself. We selected most functions SPR had, and list some proteins which have the same functions with SPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP binding | NOS3;DPYD;NOX1;CRYM;GAPDH;NOS1;PGD;FMO3;MTHFR |
| aldo-keto reductase (NADP) activity | SDR42E1;SPR;HSD11B1LA;SDR16C6;AKR1B10;MIOX;AKR7A3;AKR1C4;AKR1C3 |
| sepiapterin reductase activity | SPRB;SPRA;SPR |
SPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPR here. Most of them are supplied by our site. Hope this information will be useful for your research of SPR.
YWHAZ; midostaurin
Research Area
Related articles
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Customer Reviews (3)
Write a reviewThe production process of SPR is very environmentally friendly, using clean production technology and green raw materials, so that the production process does not emit any harmful substances.
This reproducibility of SPR is very good, and the results can be highly consistent in every experiment or application, which proves its excellent stability and reliability.
This short half-life and high clearance of SPR provide new ideas and methods for the treatment of tumors, infection and other diseases.
Q&As (6)
Ask a questionStudying the biological function of SPR proteins requires a variety of experimental techniques and methods, such as cell biology, molecular biology, biochemistry and genomics. By observing gene expression, cell proliferation, signal transduction and other indicators, the biological function of SPR protein in cells can be evaluated.
With the in-depth understanding of the structure and function of SPR protein, the drug development and application of SPR protein will be more extensive in the future. For example, the development of drugs that target the SPR protein may be used to treat tumors, autoimmune diseases, and neurological diseases. In addition, understanding the biological function of SPR proteins may also be useful for research in other areas of science.
SPR proteins have multiple domains, including calcium-binding domains, kinase domains, and regulatory domains. Among them, the calcium ion binding domain can bind to calcium ions, the kinase domain can phosphorylate downstream proteins, and the regulatory domain can regulate the activity and stability of proteins.
SPR proteins can interact with a variety of transcription factors, such as NF-kB, AP-1, and CREB. Once interacting with these transcription factors, SPR proteins can regulate gene transcription and expression, influencing the biological behavior of cells.
Due to the important role of SPR protein in cell signal transduction and gene expression regulation, drug development targeting SPR protein is of great significance. At present, some drugs targeting SPR proteins have entered clinical trials for the treatment of some human diseases.
During cell signaling, SPR proteins can interact with G protein-coupled receptors (GPCRs) and are activated by GPCRs. Once activated, SPR proteins can phosphorylate downstream proteins such as MAPK and AKT to further regulate intracellular signal transduction.
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