Recombinant Full Length Human SPR Protein, C-Flag-tagged

• Cat.No.: SPR-1089HFL
• Product Overview: Recombinant Full Length Human SPR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 27.9 kDa
• AA Sequence: MEGGLGRAVCLLTGASRGFGRTLAP LLASLLSPGSVLVLSARNDEALRQL EAELGAERSGLRVVRVPADL GAEAGLQQLLGALRELPRPKGLQRL LLINNAGSLGDVSKGFVDLSDSTQV NNYWALNLTSMLCLTSSVLK AFPDSPGLNRTVVNISSLCALQPFK GWALYCAGKAARDMLFQVLALEEPN VRVLNYAPGPLDTDMQQLAR
  ETSVDPDMRKGLQELKAKGKLVDCK VSAQKLLSLLEKDEFKSGAHVDFYD KTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways

Gene Information

• Gene Name: SPR sepiapterin reductase [ Homo sapiens (human) ]
• Official Symbol: SPR
• Synonyms: SDR38C1
• Gene ID: 6697
• mRNA Refseq: NM_003124.5
• Protein Refseq: NP_003115.1
• MIM: 182125
• UniProt ID: P35270