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STAT2

  • Official Full Name

    signal transducer and activator of transcription 2, 113kDa

  • Overview

    STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases.
  • Synonyms

    STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT2-2515H Active Recombinant Human STAT2, His-tagged Insect Cell His
Human STAT2-30904TH Recombinant Human STAT2 N/A
Human STAT2-8474H Recombinant Human STAT2, His-tagged Sf21 Insect Cell His
Human STAT2-7056H Recombinant Human STAT2, GST-tagged Sf9 Insect Cell GST Full length
Human STAT2-2997H Recombinant Human STAT2, GST-tagged E.coli GST 503-851aa
Human STAT2-332H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP 9-217 aa
Human STAT2-333H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP 274-552 aa
Human STAT2-334H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP 568-851 aa
Human STAT2-1419HCL Recombinant Human STAT2 293 Cell Lysate HEK293 N/A
Human STAT2-151H Recombinant Human STAT2 Protein, His-tagged Human Cells His
Human STAT2-6361H Recombinant Human STAT2 Protein (Glu616-Ser849), N-His tagged E.coli N-His Glu616-Ser849
Mouse Stat2-1809M Recombinant Mouse Stat2 protein, His & T7-tagged E.coli His/T7 Asn658~Ala912 (Accession # Q9WVL2)
Mouse Stat2-6169M Recombinant Mouse Stat2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Stat2-1810R Recombinant Rat Stat2 protein, His & T7-tagged E.coli His/T7 Arg587~Ile838 (Accession # Q5XI26)
Rhesus Macaque STAT2-4517R Recombinant Rhesus monkey STAT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STAT2-4333R Recombinant Rhesus Macaque STAT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STAT2-4333R-B Recombinant Rhesus Macaque STAT2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish STAT2-8272Z Recombinant Zebrafish STAT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • STAT2 Related Signal Pathway

STAT2 involved in several pathways and played different roles in them. We selected most pathways STAT2 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayRHOA;GNG11;SHC1;JAK3;CCL2;CRK;CXCL5;ROCK2;NFKBIB
Osteoclast differentiationMAPK10;FHL2;NCF2;LILRB4;NFATC1;PPP3R2;STAT1;MAP3K7;PPP3R1
Jak-STAT signaling pathwayIL15;LIF;MCL1;IL2RA;IL28RA;STAT6;IL12BA;IL23R;CRFB16
Hepatitis CPIAS1;CLDN2;PIK3CD;TRAF3;IFNA16;CLDN22;PPP2R1A;IFNA8;STAT1
Hepatitis BTGFB2;STAT5A;PIK3R2;BAX;MAP3K1;DDB2;IFNA13;IKBKG;TGFB3
MeaslesAKT2;EIF2AK1;TLR2;CD3D;TNFSF10;TBK1;NFKBIB;CCND3;TLR4
Influenza APABPN1;FURIN;RAE1;PRKCB;TNFRSF10A;IFNA3;IRF9;STAT1;AGFG1
Herpes simplex infectionCDK1;C1QBP;HLA-DRA;SRSF5;MAP3K7;TBP;LTA;CD74;TAF3

STAT2 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT2 itself. We selected most functions STAT2 had, and list some proteins which have the same functions with STAT2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFP354C;PATZ1;ZNF84;MND1;UNCX;RORCB;RPL7;HDGFRP2;PRM3
identical protein bindingTRP53;CLDN11;ALAD;TARDBP;NCAM1;GDF5;CLDN16;TRIM39;CUBN
protein bindingTFAP2A;TH1L;IGFBP2;SCYL2;TBCB;CUL5;PPIL1;IFIT3;ACD
signal transducer activityGMFB;OXTRL;CXCR4B;MGAA;TACR3A;PLCL2;ADRA1BB;CREBBP;EMR4
transcription factor activity, sequence-specific DNA bindingZNF792;ZNF567;ZNF286A;POU3F2;TP53;AHR;MEOX2;TAF4B;ZNF8

STAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT2.

STAT1; IFNAR1; IRF9

  • Q&As
  • Reviews

Q&As (5)

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How is the expression of STAT2 protein altered in certain diseases? 09/21/2022

STAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.

Are there any known genetic mutations associated with STAT2-related disorders? 03/31/2022

Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.

In what ways can the study of STAT2 protein aid in the development of novel immunotherapies? 04/16/2019

Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.

Can the assessment of STAT2 expression levels serve as a prognostic marker for certain viral infections? 01/18/2019

Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.

How do polymorphisms in the STAT2 gene influence individual susceptibility to infectious diseases? 12/16/2017

Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.

Customer Reviews (3)

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Reviews
11/17/2022

    Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

    08/20/2017

      The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

      10/02/2016

        Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

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