STAT2

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STAT2

Official Full Name signal transducer and activator of transcription 2, 113kDa
Background STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases.
Synonyms STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT2-151H Recombinant Human STAT2 Protein, His-tagged Human Cells His
    Human STAT2-1419HCL Recombinant Human STAT2 293 Cell Lysate HEK293 N/A
    Human STAT2-2515H Recombinant Human STAT2, His-tagged Insect Cell His
    Human STAT2-2997H Recombinant Human STAT2, GST-tagged E.coli GST
    Human STAT2-30904TH Recombinant Human STAT2 N/A
    Human STAT2-332H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP
    Human STAT2-333H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP
    Human STAT2-334H Recombinant Human STAT2 protein, His/MBP-tagged E.coli His/MBP
    Human STAT2-7056H Recombinant Human STAT2, GST-tagged Sf9 Insect Cell GST
    Human STAT2-8474H Recombinant Human STAT2, His-tagged Sf21 Insect Cell His
    Mouse Stat2-1809M Recombinant Mouse Stat2 protein, His & T7-tagged E.coli His/T7
    Mouse Stat2-6169M Recombinant Mouse Stat2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Stat2-1810R Recombinant Rat Stat2 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque STAT2-4517R Recombinant Rhesus monkey STAT2 Protein, His-tagged Mammalian Cell His
    Zebrafish STAT2-8272Z Recombinant Zebrafish STAT2 Mammalian Cell His

    STAT2 involved in several pathways and played different roles in them. We selected most pathways STAT2 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway BRAF; CCL27; CXCL9; CCL28; SRC; PRKACG; CCL3; SHC3; ARRB2; GNG7
    Osteoclast differentiation TGFB1; CYLD; PPP3CA; FCGR1A; MAPK11; AKT2; GRB2; SOCS3; FOS; LCP2
    Jak-STAT signaling pathway PRL2; IFNA4; Gh; FHL1B; IL20; IFNA5; CSH1; IL5; OSMR; IL6
    Hepatitis C IKBKE; PIK3CG; CLDN14; CLDN9; MAPK9; NR1H3; BRAF; IFNA7; PPARA; IFNA2
    Hepatitis B FADD; MAPK10; CXCL8; CASP10; IFNA4; ATP6AP1; CCNE1; IFNB1; IRF3; IFNA1
    Measles DDX58; RAB9B; STAT2; TNFRSF10C; PIK3R2; IRAK4; TRAF6; IFNA17; IFNA12; CLEC4M
    Influenza A TLR7; ACTB; OAS3; IFIH1; HSPA1B; EIF2AK2; SOCS3; HSPA1L; IFNA1; DDX39B
    Herpes simplex infection CSNK2A2A; SRPK1B; CDC34A; IFNA2; IL12B; CCL5; IFNA12; HLA-DOA; PVRL2; OAS2

    STAT2 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT2 itself. We selected most functions STAT2 had, and list some proteins which have the same functions with STAT2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding KHSRP; OLIG2; SCXB; IRX5B; PAX3A; CRY1; NFAT5A; ZNF672; DNASE1L1; ZNF493
    identical protein binding SEPT7; MTSS1; DIAP1; PDCD6; GOT2; SRI; GBP1; KHDRBS1; DYNLT1A; RBM10
    protein binding GNAI3; PUS7L; JAKMIP2; SIRT7; AKAP5; ZBTB7C; PDPK1; SPATA24; NAP1L4; GNA13
    signal transducer activity CHRM5A; OLFCS2; PTK2AA; PTGER4A; FST; TAS2R202; ADRA2DB; SH2B3; TACR1B; GNGT1
    transcription factor activity, sequence-specific DNA binding ATF7; PHTF1; CDX1B; ZKSCAN6; RXRAB; KLF1; TCF3; ZKSCAN14; ZSCAN20; CARF

    STAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT2.

    STAT1; IFNAR1; IRF9

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