STAT2
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Official Full Name
signal transducer and activator of transcription 2, 113kDa
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Overview
STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases. -
Synonyms
STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816;
- Recombinant Proteins
- Cell & Tissue Lysates
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- C
- His
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- Involved Pathway
- Protein Function
- Interacting Protein
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- STAT2 Related Signal Pathway
STAT2 involved in several pathways and played different roles in them. We selected most pathways STAT2 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GNB3;GM1987;CCR7;CXCL1;CRKL;STAT2;Ccl21a;CCL3L1;ROCK1 |
| Osteoclast differentiation | SIRPG;TGFBR1;FCGR4;CYBA;OSCAR;FCGR3A;MAPK3;TAB2;NOX1 |
| Jak-STAT signaling pathway | CCND2A;SOCS6B;GH2;STAT4;CSH1;CSF3;PRL;Il2;LEPA |
| Hepatitis C | CLDN8;MAPK12;IRF7;PIK3R3;PIK3R2;PIK3CG;PIK3R1;DDX58;CLDN4 |
| Hepatitis B | ATP6AP1;MAPK8;RB1;RAF1;Fasl;MAP3K1;IRF3;IFNA17;STAT5B |
| Measles | OAS1;TLR7;MAP3K7;RELA;IFNG;EIF3H;IFNA10;STAT2;TNFSF10 |
| Influenza A | PIK3R1;HSPA8;IL1A;HLA-DQA1;NFKB1;PLG;NXF1;BLB1;PIK3CB |
| Herpes simplex infection | TAF6L;PML;SOCS3B;IL12B;H2-Q10;TAF13;MHC2DAB;TNFB;IFNB |
STAT2 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT2 itself. We selected most functions STAT2 had, and list some proteins which have the same functions with STAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF763;THAP7;TCF25;IRX3B;HESX1;POLG2;ZNF614;SNAPC1;LCOR |
| identical protein binding | HSPB8;BTK;PRMT1;G6PD;NPR2;KCNRG;TRIM21;DPY30;CLDN23 |
| protein binding | ATP7B;RNF149;EIF4A2;HMG20B;SGCG;OSBPL1A;MYO6;COLGALT2;OLFM4 |
| signal transducer activity | OPN4XB;OLFR510;OLFR476;MRGPRG;FAM126A;LGR4;PRLH2R;PLCD4;CRKL |
| transcription factor activity, sequence-specific DNA binding | PHF5A;SOX13;LZTS1;MYCN;RARGA;GATA2A;TADA2A;ZNF43;GATAD2A |
STAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT2.
STAT1; IFNAR1; IRF9
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Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.
The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
Q&As (5)
Ask a questionSTAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.
Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.
Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.
Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.
Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.
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