Recombinant Rat Stat2 protein, His & T7-tagged

• Cat.No.: Stat2-1810R
• Product Overview: Recombinant Rat Stat2 aa. (Arg587~Ile838 (Accession # Q5XI26)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Rat
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 32.7kDa.
• Protein length: Arg587~Ile838 (Accession # Q5XI26)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 4.9.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: Stat2 signal transducer and activator of transcription 2 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Stat2
• Synonyms: Rnaseh2a; ribonuclease H2, large subunit; RNHL; RNHIA; RNASEHI; 2400006P09Rik; ribonuclease H2 subunit A; RNase H2 subunit A; RNase HI large subunit; ribonuclease HI large subunit; ribonuclease HI subunit A
• Gene ID: 288774
• mRNA Refseq: NM_001011905.1
• Protein Refseq: NP_001011905.1
• UniProt ID: Q5XI26

Reviews

11/17/2022

Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

08/20/2017

The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

10/02/2016

Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

Q&As

How is the expression of STAT2 protein altered in certain diseases?

STAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.

Are there any known genetic mutations associated with STAT2-related disorders?

Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.

In what ways can the study of STAT2 protein aid in the development of novel immunotherapies?

Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.

Can the assessment of STAT2 expression levels serve as a prognostic marker for certain viral infections?

Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.

How do polymorphisms in the STAT2 gene influence individual susceptibility to infectious diseases?

Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.