Recombinant Human STAT2, GST-tagged

• Cat.No.: STAT2-2997H
• Product Overview: Recombinant Human STAT2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 503-851aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ]
• Official Symbol: STAT2
• Synonyms: STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816
• Gene ID: 6773
• mRNA Refseq: NM_005419
• Protein Refseq: NP_005410
• MIM: 600556
• UniProt ID: P52630
• Chromosome Location: 12q13.2
• Pathway: Adipogenesis, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine Signaling in Immune system, organ
• Function: DNA binding; calcium ion binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity

Reviews

11/17/2022

Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

08/20/2017

The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

10/02/2016

Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

Q&As

How is the expression of STAT2 protein altered in certain diseases?

STAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.

Are there any known genetic mutations associated with STAT2-related disorders?

Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.

In what ways can the study of STAT2 protein aid in the development of novel immunotherapies?

Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.

Can the assessment of STAT2 expression levels serve as a prognostic marker for certain viral infections?

Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.

How do polymorphisms in the STAT2 gene influence individual susceptibility to infectious diseases?

Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.