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Active Recombinant Human STAT2, His-tagged

Cat.No. : STAT2-2515H
Product Overview : Recombinant human His tagged STAT2 is expressed in abaculovirussystem and purified by affinity chromatography in combination with FPLC chromatography.110 kDa.
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Cat. No. : STAT2-2515H
Description : Signal transducer and activator of transcription (STAT) proteins play a crucial role in the regulation of gene expression by mediating transcriptional responses to many cytokines and growth factors. The antiviral responses of IFN-α/β rely on the transcriptional activities of STAT1 and STAT2 proteins.The chromatin immunoprecipitation and DNA microarray analysis (Chip-chip) demonstrated that STAT2 (and STAT1) bound to chromosome 22 after IFN stimulation. STAT2 activity can be regulated by tyrosine phosphorylation that is catalyzed by a receptor associated JAK kinase.
Source : baculovirus.
Applications : Recombinant STAT2 (1-851) can be used for 1) in vitro transcription; 2) gel mobility shift assay and 3) for protein-protein interaction assay.
Transcript Variant : This variant represents the longer transcript and encodes the longer isoform.
Activity : 1 unit equals 1 nanogram of purified protein.
Quality Control : The purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase and RNase activity.
Reagents Supplied : 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
Storage Conditions : Store at -80°C.
Pathways : Chemokine signaling pathway; Jak-STAT signaling pathway
Gene Name : STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ]
Synonyms : STAT2; signal transducer and activator of transcription 2, 113kDa; P113; ISGF-3; STAT113; MGC59816; interferon alpha induced transcriptional activator; Signal transducer and activator of transcription 2; p113; signal transducer and activator of transcription 2, 113kD
Gene ID : 6773
mRNA Refseq : NM_005419
Protein Refseq : NP_005410
MIM : 600556
UniProt ID : P52630
Chromosome Location : 12q13.3
Function : calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; signal transducer activity; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is the expression of STAT2 protein altered in certain diseases? 09/21/2022

STAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.

Are there any known genetic mutations associated with STAT2-related disorders? 03/31/2022

Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.

In what ways can the study of STAT2 protein aid in the development of novel immunotherapies? 04/16/2019

Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.

Can the assessment of STAT2 expression levels serve as a prognostic marker for certain viral infections? 01/18/2019

Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.

How do polymorphisms in the STAT2 gene influence individual susceptibility to infectious diseases? 12/16/2017

Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.

Customer Reviews (3)

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Reviews
11/17/2022

    Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

    08/20/2017

      The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

      10/02/2016

        Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

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