Active Recombinant Human STAT2, His-tagged
Cat.No. : | STAT2-2515H |
Product Overview : | Recombinant human His tagged STAT2 is expressed in abaculovirussystem and purified by affinity chromatography in combination with FPLC chromatography.110 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | STAT2-2515H |
Description : | Signal transducer and activator of transcription (STAT) proteins play a crucial role in the regulation of gene expression by mediating transcriptional responses to many cytokines and growth factors. The antiviral responses of IFN-α/β rely on the transcriptional activities of STAT1 and STAT2 proteins.The chromatin immunoprecipitation and DNA microarray analysis (Chip-chip) demonstrated that STAT2 (and STAT1) bound to chromosome 22 after IFN stimulation. STAT2 activity can be regulated by tyrosine phosphorylation that is catalyzed by a receptor associated JAK kinase. |
Source : | baculovirus. |
Applications : | Recombinant STAT2 (1-851) can be used for 1) in vitro transcription; 2) gel mobility shift assay and 3) for protein-protein interaction assay. |
Transcript Variant : | This variant represents the longer transcript and encodes the longer isoform. |
Activity : | 1 unit equals 1 nanogram of purified protein. |
Quality Control : | The purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase and RNase activity. |
Reagents Supplied : | 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT. |
Storage Conditions : | Store at -80°C. |
Pathways : | Chemokine signaling pathway; Jak-STAT signaling pathway |
Gene Name : | STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ] |
Synonyms : | STAT2; signal transducer and activator of transcription 2, 113kDa; P113; ISGF-3; STAT113; MGC59816; interferon alpha induced transcriptional activator; Signal transducer and activator of transcription 2; p113; signal transducer and activator of transcription 2, 113kD |
Gene ID : | 6773 |
mRNA Refseq : | NM_005419 |
Protein Refseq : | NP_005410 |
MIM : | 600556 |
UniProt ID : | P52630 |
Chromosome Location : | 12q13.3 |
Function : | calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity; protein binding; signal transducer activity; transcription factor activity |
Products Types
◆ Recombinant Protein | ||
Stat2-6169M | Recombinant Mouse Stat2 Protein, Myc/DDK-tagged | +Inquiry |
STAT2-4333R | Recombinant Rhesus Macaque STAT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT2-4517R | Recombinant Rhesus monkey STAT2 Protein, His-tagged | +Inquiry |
STAT2-333H | Recombinant Human STAT2 protein, His/MBP-tagged | +Inquiry |
STAT2-151H | Recombinant Human STAT2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
STAT2-1419HCL | Recombinant Human STAT2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSTAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.
Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.
Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.
Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.
Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.
Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.
The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
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