Recombinant Human STAT2, His-tagged
Cat.No. : | STAT2-8474H |
Product Overview : | Recombinant Human STAT2, fused with His tag, was expressed in Sf21 Cells. |
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Description : | The signal transducer and activator of transcription (STAT) proteins play a crucial role in the regulation of gene expression by mediating transcriptional responses to many cytokines and growth factors . The antiviral responses of IFN-alpha/beta rely on the transcriptional activities of STAT1 (cat# R1072) and STAT2 proteins . The chromatin immunoprecipitation and DNA microarray analysis (Chip-chip) demonstrated that STAT2 (and STAT1) bound to chromosome 22 after IFN stimulation. STAT2 activity can be regulated by tyrosine phosphorylation that is catalyzed by a receptor associated JAK kinase . |
Source : | Sf21 Cells |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
AA Sequence : | MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG SDDSKATMLF FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD PTQLAEMIFN LLLEEKRILI QAQRAQLEQG EPVLETPVES QQHEIESRIL DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ AKGKTPSLDP HQTKEQKILQ ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA QQQKACIRAP IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL QEGNESLTVE VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF GYLTLVEQRS GGSGKGSNKG PLGVTEELHI ISFTVKYTYQ GLKQELKTDT LPVVIISNMN QLSIAWASVL WFNLLSPNLQ NQQFFSNPPK APWSLLGPAL SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD FTKRESPPGK LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL LTEENIPENP LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN RQVDELQQPL ELKPEPELES LELELGLVPE PELSLDLEPL LKAGLDLGPE LESVLESTLE PVIEPTLCMV SQTVPEPDQG PVSQPVPEPD LPCDLRHLNT EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF YTDGPLMPSD F |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 800 μg/ml |
Shipping : | Dry Ice |
Gene Name : | STAT2 signal transducer and activator of transcription 2, 113kDa [ Homo sapiens ] |
Official Symbol : | STAT2 |
Synonyms : | STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816; |
Gene ID : | 6773 |
mRNA Refseq : | NM_005419 |
Protein Refseq : | NP_005410 |
MIM : | 600556 |
UniProt ID : | P52630 |
Chromosome Location : | 12q13.2 |
Pathway : | Adipogenesis, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Hepatitis C, organism-specific biosystem; |
Function : | DNA binding; calcium ion binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; |
Products Types
◆ Recombinant Protein | ||
Stat2-6169M | Recombinant Mouse Stat2 Protein, Myc/DDK-tagged | +Inquiry |
STAT2-4333R | Recombinant Rhesus Macaque STAT2 Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT2-333H | Recombinant Human STAT2 protein, His/MBP-tagged | +Inquiry |
Stat2-1809M | Recombinant Mouse Stat2 protein, His & T7-tagged | +Inquiry |
STAT2-334H | Recombinant Human STAT2 protein, His/MBP-tagged | +Inquiry |
◆ Lysates | ||
STAT2-1419HCL | Recombinant Human STAT2 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.
The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
Q&As (5)
Ask a questionSTAT2 expression can be upregulated or downregulated in different diseases, leading to dysregulated immune responses and potential susceptibility to certain infections or autoimmune conditions.
Yes, certain genetic mutations in the STAT2 gene have been linked to primary immunodeficiency disorders, impacting the body's ability to mount an effective immune response.
Understanding the intricate signaling pathways involving STAT2 can provide insights into potential targets for immunotherapy, offering promising avenues for the treatment of various immune-related disorders and cancers.
Yes, the evaluation of STAT2 expression levels can provide valuable insights into the immune status of individuals and may serve as a prognostic marker for the severity and outcome of specific viral infections.
Polymorphisms in the STAT2 gene can impact the individual's susceptibility to specific infectious diseases by altering the host's immune response and the ability to effectively combat pathogens.
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