STAT5A

  • Official Full Name

    STAT5A signal transducer and activator of transcription 5A

  • Synonyms

    STAT5A; signal transducer and activator of transcription 5A; STAT5; MGF;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DYKDDDDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT5A-340H Recombinant Human STAT5A protein, His/MBP-tagged E.coli His/MBP 1-104 aa
Human STAT5A-1498H Recombinant Human STAT5A, His-tagged Sf9 Insect Cell His
Human STAT5A-341H Recombinant Human STAT5A protein, His/MBP-tagged E.coli His/MBP 148-316 aa
Human STAT5A-342H Recombinant Human STAT5A protein, His/MBP-tagged E.coli His/MBP 376-567 aa
Human STAT5A-01H Recombinant Human STAT5a, His-tagged E.coli His
Human STAT5A-1416HCL Recombinant Human STAT5A 293 Cell Lysate HEK293 N/A
Human STAT5A-352HFL Recombinant Full Length Human STAT5A Protein, C-Flag-tagged Mammalian cells Flag
Human STAT5A-151H Recombinant Human STAT5A Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human STAT5A-0729H Recombinant Human STAT5A protein, His-tagged E.coli His Ala136-Glu705
Human STAT5A-2117H Recombinant Human STAT5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human STAT5A-4962H Recombinant Human STAT5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT5A-6364H Recombinant Human STAT5A Protein (Met1-Ser794), N-His tagged E.coli N-His Met1-Ser794
Human STAT5A-2117H-B Recombinant Human STAT5A Protein Pre-coupled Magnetic Beads HEK293
Mouse Stat5a-6172M Recombinant Mouse Stat5a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat STAT5A-5779R Recombinant Rat STAT5A Protein Mammalian Cell His
Rat STAT5A-5438R Recombinant Rat STAT5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat STAT5A-5438R-B Recombinant Rat STAT5A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque STAT5A-4518R Recombinant Rhesus monkey STAT5A Protein, His-tagged Mammalian Cell His
Rhesus Macaque STAT5A-4334R-B Recombinant Rhesus Macaque STAT5A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque STAT5A-4334R Recombinant Rhesus Macaque STAT5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish STAT5A-9737Z Recombinant Zebrafish STAT5A Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • STAT5A Related Signal Pathway

What is STAT5A protein?

The STAT5A protein, also known as signal transducer and activator of transcription 5A, is a transcription factor involved in mediating the signaling of cytokines and growth factors. It plays a crucial role in various cellular processes such as cell growth, differentiation, and immune response. STAT5A is predominantly expressed in hematopoietic cells and is activated by phosphorylation upon binding of specific ligands to cell surface receptors. Activation of STAT5A leads to its dimerization, nuclear translocation, and binding to specific DNA sequences, resulting in the regulation of target gene expression.

What is the function of STAT5A protein?

Cell proliferation and survival: STAT5A activates genes involved in cell cycle progression and inhibition of apoptosis. This promotes growth and maintenance of cells.

Hematopoiesis: It plays a key role in the development and maintenance of various blood cell lineages like red blood cells, lymphocytes etc. in response to cytokines.

Mammary gland development: STAT5A is crucial for lobuloalveolar maturation and lactation. It regulates milk protein gene expression during pregnancy and lactation.

Immune cell development: It is important for differentiation and functions of multiple immune cell types like T cells, B cells, neutrophils, macrophages etc.

STAT5A related signaling pathway

JAK/STAT pathway: Binding of ligands like Epo, GH or PRL to their receptors leads to JAK kinase activation. JAKs then phosphorylate STAT5A.

PI3K/Akt pathway: STAT5A activation can induce PI3K, resulting in Akt phosphorylation. Akt promotes cell survival.

Ras/Raf/MEK/ERK pathway: STAT5A assists activation of the Ras pathway, regulating gene expression, cell growth and proliferation.

STAT5A Related Diseases

  •  Cancer: Constitutively active STAT5A promotes growth and survival in blood cancers like ALL, CML, AML. It's a therapeutic target.
  •  Immunodeficiency: Heterozygous mutations in STAT5A cause autosomal dominant hyper-IgE syndrome with immune defects.
  •  Primary ovarian insufficiency: STAT5A involvement is implicated in premature menopause and infertility in some cases.
  •  Short stature: STAT5A deficiency due to gene deletions causes short stature in both sexes via growth hormone insensitivity.
  •  Mammary gland diseases: Abnormal STAT5A levels impact lobuloalveolar development in conditions like mastitis or breast cancer.
  •  Cancer therapy: Inhibiting constitutively active STAT5A can treat blood cancers, making it a targeted therapy candidate.
  •  Hematopoietic stem cell regulation: Modulating STAT5A levels guides proper HSC self-renewal, differentiation and blood production.
  •  Immunotherapy development: STAT5A regulates immune cell development and function, so can be leveraged to enhance vaccine responses.
  •  Cancer therapy: Inhibiting constitutively active STAT5A can treat blood cancers, making it a targeted therapy candidate.
  •  Hematopoietic stem cell regulation: Modulating STAT5A levels guides proper HSC self-renewal, differentiation and blood production.
  •  Immunotherapy development: STAT5A regulates immune cell development and function, so can be leveraged to enhance vaccine responses.

High Purity

SDS-PAGE STAT5A-6364H.jpg

Fig1. SDS-PAGE (Cat. No.: STAT5A-6364H)

transfection with Stat5a siRNA.jpg

(Ayush Dagvadorj, 2008)

Fig2. Stereomicroscope photographs of LNCaP cells 72 h after transfection with Stat5a/b siRNA, scrambled control (control siRNA), medium containing transfection reagent, or untreated cells. Inhibition of Stat5a/b by RNA interference induced cell rounding, detachment, shrinkage, and blebbing.

high expression of p-STAT5A.jpg

(Shanglin Wang, 2023)

Fig3. In the 90 IHC patients, Kaplan-Meier survival curves using log-rank test showed poor overall survival in patients with high expression of p-STAT5A expression compared with those in the low expression group.

STAT5A involved in several pathways and played different roles in them. We selected most pathways STAT5A participated on our site, such as ErbB signaling pathway, Jak-STAT signaling pathway, Prolactin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayERBB3B;NRG2;MAP2K4;PIK3R3;RAF1B;PRKCBA;ERBB4;GAB1;CBLC
Jak-STAT signaling pathwayCRFB4;AOX3;NT5C3;IL6;AOX4;MPL;PTPN11;IFNW1;LEP
Prolactin signaling pathwaySLC2A2;ESR1;PIK3CB;SHC3;SHC1;PPIB;MAP2K1;TH;MAPK10
Hepatitis BGRB2;PRKCG;MAP3K1;IFNA14;DDX58;STAT6;STAT1;SMAD3;IKBKG
MeaslesTLR7;HSPA6;EIF2AK1;EIF2AK2;TAB2;EIF2AK3;TLR4;CD3E; CD3D;NFKB1
HTLV-I infectionPOLE3;POLD1;WNT1;STAT5A;NRP1;STAT5B;PDGFB;ICAM1;RAN
Pathways in cancerFZD1;ZBTB16;WNT11;SMAD2;STAT3;TPM3;GNG5;GNG13;IKBKB
Viral carcinogenesisPRKACB;Casp3;LTBR;HIST2H2BB;IL6ST;HDAC10;NFKB1;YWHAG;CCND3
Chronic myeloid leukemiaPIK3CB;TRP53;BCR;CBLB;GRB2;IKBKB;CTBP2;TGFBR1;RAF1
Acute myeloid leukemiaARAF;HRAS;CHUK;CCND1;PIK3R1;MYC;TCF7L2;STAT5A;RAF1

STAT5A has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT5A itself. We selected most functions STAT5A had, and list some proteins which have the same functions with STAT5A. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingSPI1;RBPJ;TFAP2B;GATA3;YAP1;MITF;TAL1;SFPI1;TCF7L2
protein bindingRNASE1;EFNB1;FZD7;PRAC;ATXN7L1;GLRA1;GLI3;PEX12;STXBP3A
signal transducer activityTAS2R104;HCAR1-1;OLFR8;TAAR11;GRM6B;ILK;TRIM63;STAT4;TOLLIP
transcription factor activity, sequence-specific DNA bindingFOXQ1B;MYRFL;SUPT4H1;ZFP110;BCL6;TBX24;ZNF821;MECOM;HOXB7

STAT5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT5A here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT5A.

PTPN1; TCF12; AGAP2; STAP2; il2ra_human_gene

Gene Family

Cytokines

Research Area

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Customer Reviews (3)

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Reviews
10/17/2022

    The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.

    10/04/2016

      Its reliable bioactivity makes it an ideal choice for a diverse range of experimental applications.

      05/29/2016

        By providing comprehensive data and resources, the manufacturer enables researchers to design and implement their trials with confidence, ensuring the desired outcomes.

        Q&As (5)

        Ask a question
        How does STAT5A contribute to immune system regulation? 01/28/2022

        STAT5A plays a crucial role in regulating immune responses by influencing the differentiation and function of immune cells such as T cells and natural killer cells.

        Are there any ongoing clinical trials targeting STAT5A? 12/01/2020

        Yes, several clinical trials are exploring the therapeutic potential of targeting STAT5A in different cancer types.

        What challenges are associated with targeting STAT5A in clinical applications? 07/17/2019

        One challenge is the need for specificity in targeting STAT5A to avoid adverse effects on normal cellular functions.

        Can STAT5A be a prognostic marker in cancer patients? 01/05/2018

        Elevated levels of activated STAT5A have been correlated with poor prognosis in certain cancers, suggesting its potential as a prognostic marker.

        In which diseases are dysregulations of STAT5A associated? 12/25/2017

        Dysregulations of STAT5A have been linked to leukemia, breast cancer, and prostate cancer, among other diseases.

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