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Recombinant Human STAT5A, His-tagged
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Cat.No. : | STAT5A-1498H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant full-length human STAT5 was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 92 kDa. |
Description : | STAT5 (signal transducers and activators of transcription 5) is a member of the STAT family and this protein is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors. The differentiation of T helper (Th) cells is regulated by members of the STAT family of signaling molecules. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and increased resistance to induction of apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
PDB rendering based on 1y1u. : |
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Gene Name : | STAT5A signal transducer and activator of transcription 5A [ Homo sapiens ] |
Synonyms : | STAT5A; signal transducer and activator of transcription 5A; MGF; STAT5; STAT5 |
Gene ID : | 6776 |
mRNA Refseq : | NM_003152 |
Protein Refseq : | NP_003143 |
MIM : | 601511 |
UniProt ID : | P42229 |
Chromosome Location : | 17q11.2 |
Pathway : | Acute myeloid leukemia; Chronic myeloid leukemia; ErbB signaling pathway; Jak-STAT signaling pathway; Pathways in cancer |
Function : | calcium ion binding; phosphate binding; protein binding; signal transducer activity; transcription factor activity |
◆ Recombinant Protein
Stat5a-6172M | Recombinant Mouse Stat5a Protein, Myc/DDK-tagged | +Inquiry |
STAT5A-340H | Recombinant Human STAT5A protein, His/MBP-tagged | +Inquiry |
STAT5A-151H | Recombinant Human STAT5A Protein, DYKDDDDK-tagged | +Inquiry |
STAT5A-5779R | Recombinant Rat STAT5A Protein | +Inquiry |
STAT5A-01H | Recombinant Human STAT5a, His-tagged | +Inquiry |
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◆ Lysates
STAT5A-1416HCL | Recombinant Human STAT5A 293 Cell Lysate | +Inquiry |
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