| Description : |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
90.5 kDa |
| AA Sequence : |
MAGWIQAQQLQGDALRQMQVLYGQH FPIEVRHYLAQWIESQPWDAIDLDN PQDRAQATQLLEGLVQELQK KAEHQVGEDGFLLKIKLGHYATQLQ KTYDRCPLELVRCIRHILYNEQRLV REANNCSSPAGILVDAMSQK HLQINQTFEELRLVTQDTENELKKL QQTQEYFIIQYQESLRIQAQFAQLA QLSPQERLSRETALQQKQVS LEAWLQREAQTLQQYRVELAEKHQK TLQLLRKQQTIILDDELIQWKRRQQ LAGNGGPPEGSLDVLQSWCE KLAEIIWQNRQQIRRAEHLCQQLPI PGPVEEMLAEVNATITDIISALVTS TFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNECSGEILNNC CVMEYHQATGTLSAHFRNMS LKRIKRADRRGAESVTEEKFTVLFE SQFSVGSNELVFQVKTLSLPVVVIV HGSQDHNATATVLWDNAFAE PGRVPFAVPDKVLWPQLCEALNMKF KAEVQSNRGLTKENLVFLAQKLFNN SSSHLEDYSGLSVSWSQFNR ENLPGWNYTFWQWFDGVMEVLKKHH KPHWNDGAILGFVNKQQAHDLLINK PDGTFLLRFSDSEIGGITIA WKFDSPERNLWNLKPFTTRDFSIRS LADRLGDLSYLIYVFPDRPKDEVFS KYYTPVLAKAVDGYVKPQIK QVVPEFVNASADAGGSSATYMDQAP SPAVCPQAPYNMYPQNPDHVLDQDG EFDLDETMDVARHVEELLRR
PMDSLDSRLSPPAGLFTSARGSLST RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
| Protein Pathways : |
Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer |
