SUPT5H
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Official Full Name
suppressor of Ty 5 homolog -
Overview
DRB-sensitivity inducing factor (DSIF), a heterodimer composed of SPT4 and SPT5, is capable of both facilitating and inhibiting RNA polymerase II (RNAPII) activity. DSIF, together with NELF (Negative Elongation Factor), inhibits RNAPII elongation, resulti -
Synonyms
SUPT5H;suppressor of Ty 5 homolog (S. cerevisiae);suppressor of Ty (S.cerevisiae) 5 homolog;transcription elongation factor SPT5;FLJ34157;SPT5;SPT5H;hSPT5;DSIF p160;DSIF large subunit;Tat-cotransactivator 1 protein;DRB sensitivity-inducing fact
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
SUPT5H involved in several pathways and played different roles in them. We selected most pathways SUPT5H participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat,Disease,Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUPT5H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the Early Elongation Complex | COBRA1,WHSC2,CTDP1,NELFE,RDBP,GM3258,TH1L,SUPT4H1 |
| Gene Expression | LBH,ZNF688,HNRNPA0B,IPO8,CD2BP2,AGO3B,C2orf29,ZNF583,NR2C2AP,ZNF394 |
| Disease | CTDP1,OPN1LW,PSIP1,AP2A1,RCC1,TRAT1,SYT2,NMT2,IPO5,LRRFIP1 |
| Formation of RNA Pol II elongation complex | PSTPIP2,ELL,SUPT16H,RDBP,SUPT4H1,CCNT2B,TCEB3,TH1L,SSRP1,CDK9 |
| Formation of HIV elongation complex in the absence of HIV Tat | COBRA1,TCEB3,SUPT4H1,TCEA1,RDBP,SSRP1,CTDP1,TH1L,PSTPIP2,WHSC2 |
| Formation of the HIV-1 Early Elongation Complex | TH1L,CTDP1,SUPT4H1,COBRA1,RDBP,WHSC2 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | TCEB3,RDBP,TH1L,WHSC2,CTDP1,CDK9,SUPT4H1,COBRA1,TCEA1,ELL |
| Abortive elongation of HIV-1 transcript in the absence of Tat | WHSC2,CTDP1,SUPT4H1,COBRA1,TH1L,RDBP |
Protein Function
SUPT5H has several biochemical functions, for example, chromatin binding,enzyme binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUPT5H itself. We selected most functions SUPT5H had, and list some proteins which have the same functions with SUPT5H. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | TAF15,CS,DDX42,FAU,KPNA2,MRPL3,KIAA1429,SSB,RRP1,COA6 |
| protein heterodimerization activity | HIST1H4F,ARNT2,DRAP1,TWIST1,CLCN3,INHBA,HIF1A,ITGA3,HEXA,SMC2 |
| enzyme binding | KDM1A,LDB2,TRP53,ANK1,HIST1H2AI,MSH2,PPP1R3B,PLCE1,A2M,SCN5A |
| protein binding | FAM118B,WDR92,PLEK,PITPNM3,NUCB2,NEK3,DPEP1,PRLR,CALD1,FKBP5 |
| chromatin binding | Ar,MBD1,ACTL6A,GLI3,TCF7L1A,RAG2,GLI2,ARNTL1B,NSBP1,POU2F1 |
Interacting Protein
SUPT5H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUPT5H here. Most of them are supplied by our site. Hope this information will be useful for your research of SUPT5H.
SUPT4H1;POLR2A;NELFA;TERF1;PPIA;SNX4;ZFYVE9;HSPB1;H2AFX;HTT
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