SYK
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Official Full Name
spleen tyrosine kinase
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Overview
Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor t -
Synonyms
SYK; spleen tyrosine kinase; tyrosine-protein kinase SYK; p72-Syk; FLJ25043; FLJ37489; DKFZp313N1010;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SYK involved in several pathways and played different roles in them. We selected most pathways SYK participated on our site, such as NF-kappa B signaling pathway, Phospholipase D signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | CXCL12;MYD88;CCL19;PIDD1;CCL13;TAB2;TNFRSF13C;BCL2A1;TRAF5 |
| Phospholipase D signaling pathway | ARF6;PLCG2;PPAP2B;PIK3CB;SYK;AKT2;PLCB1;SPHK1;MAPK3 |
| PIK-Akt signaling pathway | TNXB;ITGB3;MCL1;RBL2;TSC2;IFNA7;YWHAG;GNG4;NRAS |
| Osteoclast differentiation | BLNK;NCF2;SOCS3;LILRA2;LILRB1;RELB;CSF1R;SYK;MITF |
| Platelet activation | PLCB4;GNAQ;MAPK1;GUCY1B3;PLA2G4D;PIK3CB;PTGIR;VWF;PRKACA |
| Natural killer cell mediated cytotoxicity | PRF1;NCR2;GZMB;IFNA21;RAC3;ULBP1;NCR1;NFATC2;SAMD3 |
| B cell receptor signaling pathway | NFATC3;ARPC4;MALT1;DOK3;ARPC3;HDAC5;SYK;CMTM3;LCP2A |
| Fc epsilon RI signaling pathway | SYK;LAT;VAV3;AKT2;BTK;PIK3CG;PIK3CD;PLCG2;MAP2K7 |
| Fc gamma R-mediated phagocytosis | RAC2;PIK3R5;PIK3CB;RAF1;WASF1;DOCK2;LIMK2;MAPK3;PIK3CD |
| Tuberculosis | CAMP;CAMK2G;BCL10;CD209C;BAD;RFXAP;CD14;CLEC4E;MAPK3 |
| Epstein-Barr virus infection | HSPA6;PSMC3;POLR3B;GTF2E1;ENTPD1;POLR2E;MAPK9;CD44;YWHAH |
| Viral carcinogenesis | HLA-B;SP100;GTF2H4;HIST1H2BH;Casp3;PIK3CD;TBPL1;PIK3CB;STAT5A |
SYK has several biochemical functions, for example, ATP binding, integrin binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYK itself. We selected most functions SYK had, and list some proteins which have the same functions with SYK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CCC2;CSNK1G1;CAMK2B1;GALK1;CDK1;CAMK2D2;SEPHS1;VMHC;IARS |
| integrin binding | ADAM22;PTPN2;ACTN2;CD9;TNN;CALR;ICAM2;COL3A1;ICAM5 |
| non-membrane spanning protein tyrosine kinase activity | WEE1;TYK2;TNK2B;PTK6B;PRKCD;FYN;FER;FRK;DYRK1A |
| protein binding | USP36;CASP6;WDR61;UBAC1;GINS2;CTNNA2;RFFL;AAK1;C7orf42 |
| protein kinase activity | PRKAA2;RPS6KA5;BMPR1AA;ACVR2AA;STK25B;PRKAB1;BMPR1AB;CDKL3;EPHB3A |
| protein kinase binding | CCNYL1;TPX2;AGTR1A;MAP3K2;FAM83A;ATF2;CDKN2D;TPRKB;CDC25A |
| protein serine/threonine kinase activity | BMPR1BA;MAPKAPK5;AKT3;TSSK6;PRKAA2;STK11;CSNK1A1;CAMKK1B;DYRK1B |
| protein tyrosine kinase activity | DSTYK;DYRK2;FGR;ERBB3A;FER;KIT;FYNB;TESK1;KIAA1804 |
| receptor signaling protein tyrosine kinase activity | EGFR;ERBB4A;KITB;TYRO3;ERBB2;KITA;KIT;ERBB3B;LYN |
SYK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYK here. Most of them are supplied by our site. Hope this information will be useful for your research of SYK.
LCK; CBL; STAT3; USP25
Research Area
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