TDGF1

  • Official Full Name

    teratocarcinoma-derived growth factor 1

  • Overview

    This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
  • Synonyms

    TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • Fc
  • hFc
  • His
  • GST
  • His(C
  • ter)
  • human|IgG1|Fc
  • MBP
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TDGF1-526H Active Recombinant Human TDGF1 Sf21 Insect Cell N/A Leu31-Thr172 & Ser63-Thr172
Human TDGF1-78H Active Recombinant Human TDGF1 protein, T7/His-tagged E.coli T7/His
Human TDGF1-496H Active Recombinant Human TDGF1, Fc Chimera HEK293 Fc
Human TDGF1-592H Active Recombinant Human Teratocarcinoma-derived Growth Factor 1 Human N/A
Human TDGF1-1048H Recombinant Human TDGF1 protein(Met1-Thr172), hFc-tagged HEK293 C-hFc Met1-Thr172
Human TDGF1-2904H Recombinant Human TDGF1, MBP E.coli MBP
Human TDGF1-497H Recombinant Human TDGF1 protein, Fc-tagged HEK293 human/IgG1/Fc Leu31-Thr172
Human TDGF1-3170H Recombinant Human TDGF1, GST-tagged E.coli GST 1-188aa
Human TDGF1-27821TH Recombinant Human TDGF1, Fc-tagged Fc
Human TDGF1-27822TH Recombinant Human TDGF1, MBP-tagged E.coli MBP
Human TDGF1-3350H Active Recombinant Human TDGF1 protein, His-tagged HEK293 His Met1-Thr172
Human TDGF1-2432HCL Recombinant Human TDGF1 cell lysate Human Cell N/A
Human TDGF1-3555H Recombinant Human TDGF1 protein, His-tagged E.coli His 32-150aa
Human TDGF1-3556H Recombinant Human TDGF1 protein, GST-tagged E.coli GST 32-150aa
Human TDGF1-001H Recombinant Human TDGF1 Protein, MBP-tagged E.coli MBP 1-188
Human TDGF1-295H Recombinant Human TDGF1 Protein, His-tagged(C-ter) HEK293 His(C-ter) Leu31-Thr172
Human TDGF1-572H Active Recombinant Human TDGF1 protein, His-tagged HEK293 His Met1-Asp150
Human TDGF1-573H Active Recombinant Human TDGF1 protein, hFc-tagged HEK293 hFc Met1-Asp150
Human TDGF1-562H Recombinant Human TDGF1 Protein, Fc-tagged HEK293 Fc 188
Human TDGF1-6407H Recombinant Human TDGF1 Protein (Leu31-Ser169), C-Fc tagged Mammalian cells C-Fc Leu31-Ser169
Rat TDGF1-1082R Recombinant Rat TDGF1 Protein, Fc-tagged HEK293 Fc
Rat TDGF1-166R Recombinant Rat Tdgf1, His tagged Human Cell N/A
Rat TDGF1-832RCL Recombinant Rat TDGF1 cell lysate Human Cell N/A
Rat TDGF1-1254R Recombinant Rat TDGF1 protein(Met1-Cys143), His-tagged HEK293 C-His Met1-Cys143
Zebrafish TDGF1-8718Z Recombinant Zebrafish TDGF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TDGF1 involved in several pathways and played different roles in them. We selected most pathways TDGF1 participated on our site, such as Developmental Biology, Glypican 1 network, POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyCOL9A1A;COL4A4;GFRA1;MED15;GDNF;DPYSL4;DUSP9;MED21;SALL4
Glypican 1 network
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationNR6A1;FOXD3;TDGF1
Regulation of signaling by NODALTDGF1;ACVR1C;CFC1;LEFTY1
Signaling by NODALFOXH1;PCSK6;CFC1;TDGF1;DRAP1;LEFTY1;GDF1;ACVR1C
Transcriptional regulation of pluripotent stem cellsLIN28A;HIF3A;NR6A1;PRDM14;POU5F3;FOXD3;NR5A1;SALL4;TDGF1

TDGF1 has several biochemical functions, for example, growth factor activity, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDGF1 itself. We selected most functions TDGF1 had, and list some proteins which have the same functions with TDGF1. You can find most of the proteins on our site.

Function Related Protein
growth factor activityGDF3;HGF;AMBN;LACRT;FGF14;LEFTY1;F2;CTGF;FGF6A
protein bindingCARS;CCDC64;SARM1;PSMB5;PTPRD;CCK;HMOX1;THOC2;CCDC135
receptor bindingNTF7;MAG;FGF12B;NMU;CADM1;Fert2;CD200;PVRL4;PTK2B

TDGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDGF1.

GPC1; GDF9; ANG; FBLN1; BAG6; AP2S1; RIF1; COPS6; FARSA

  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
01/13/2020

    the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of TDGF1 protein in trials.

    03/26/2018

      manufacturers often have a wealth of knowledge and expertise in the field of TDGF1 protein research.

      08/29/2017

        They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of TDGF1 protein in their studies.

        Q&As (5)

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        Is TDGF1 associated with any genetic disorders? 01/26/2021

        Mutations in the TDGF1 gene have been linked to certain congenital disorders. Understanding these genetic associations can provide insights into the underlying mechanisms of these conditions.

        How does TDGF1 influence neurodevelopment? 02/11/2020

        TDGF1 has been found to play a role in neural development. It is involved in the specification of neural cell fate and the formation of the neural tube during embryogenesis.

        Can TDGF1 be a target for drug development? 06/27/2019

        Yes, efforts are underway to develop drugs that modulate TDGF1 activity. Targeting TDGF1 could potentially lead to novel therapies for conditions related to cell growth and differentiation.

        In what ways does TDGF1 contribute to stem cell biology? 06/04/2019

        TDGF1 is involved in the maintenance of pluripotency in embryonic stem cells. Understanding its role could enhance our ability to control and manipulate stem cells for therapeutic purposes.

        How can TDGF1 be utilized in cancer diagnostics? 10/09/2016

        Researchers are exploring the use of TDGF1 as a biomarker for certain cancers. Detection of elevated TDGF1 levels in patient samples may aid in early cancer diagnosis.

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