Recombinant Human TDGF1 Protein, MBP-tagged

• Cat.No.: TDGF1-001H
• Product Overview: Recombinant Human TDGF1 Protein (1-188 aa (full-length)) with MBP tag was expressed in E. coli.

Specification

• Description: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: MBP
• Molecular Mass: 65.8 kDa
• Protein length: 1-188
• Purity: >95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB).
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB), immunoblotting with anti-MBP (WB) and peptide fingerprinting by MALDI-TOF mass spectrometry.
• Storage: Prior to reconstitution, store the lyophilized protein at 2−8 centigrade. After reconstitution, store in working aliquots at −80 centigrade.
• Expiry: All components are stable for 1 year of receipt, if stored properly.
• Storage Buffer: Lyophilized from a solution of phosphate buffered saline (PBS), pH 7.4, containing 0.50 mg TDGF1 per ml. No preservatives added.
• Shipping: Lyophilized at Ambient temperature

Gene Information

• Gene Name: TDGF1 teratocarcinoma-derived growth factor 1 [ Homo sapiens (human) ]
• Official Symbol: TDGF1
• Synonyms: TDGF1; teratocarcinoma-derived growth factor 1; CR; CR-1; CRGF; CRIPTO; teratocarcinoma-derived growth factor 1; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1
• Gene ID: 6997
• mRNA Refseq: NM_003212
• Protein Refseq: NP_003203
• MIM: 187395
• UniProt ID: P13385

Reviews

01/13/2020

the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of TDGF1 protein in trials.

03/26/2018

manufacturers often have a wealth of knowledge and expertise in the field of TDGF1 protein research.

08/29/2017

They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of TDGF1 protein in their studies.

Q&As

Is TDGF1 associated with any genetic disorders?

Mutations in the TDGF1 gene have been linked to certain congenital disorders. Understanding these genetic associations can provide insights into the underlying mechanisms of these conditions.

How does TDGF1 influence neurodevelopment?

TDGF1 has been found to play a role in neural development. It is involved in the specification of neural cell fate and the formation of the neural tube during embryogenesis.

Can TDGF1 be a target for drug development?

Yes, efforts are underway to develop drugs that modulate TDGF1 activity. Targeting TDGF1 could potentially lead to novel therapies for conditions related to cell growth and differentiation.

In what ways does TDGF1 contribute to stem cell biology?

TDGF1 is involved in the maintenance of pluripotency in embryonic stem cells. Understanding its role could enhance our ability to control and manipulate stem cells for therapeutic purposes.

How can TDGF1 be utilized in cancer diagnostics?

Researchers are exploring the use of TDGF1 as a biomarker for certain cancers. Detection of elevated TDGF1 levels in patient samples may aid in early cancer diagnosis.