Active Recombinant Human TDGF1 Protein, Tag Free

• Cat.No.: TDGF1-592H
• Product Overview: TDGF1 Human Recombinant produced in HEK-293 cells is a single, glycosylated, polypeptide chain containing 139 amino acids with a molecular weight of 17.8 kDa though on SDS-PAGE migrates at about 25kDa due to the glycosilation. The TDGF1 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: TDGF1-592H
• Description: TDGF1 is an extracellular, membrane-bound signaling protein that is involved in embryonic development and tumor growth. Mutations in TDGF1 are associated with forebrain defects TDGF1 takes part in the determination of the epiblastic cells that later provide growth to the mesoderm.
• Source: Human
• Host: HEK293-F Cells.
• Form: The TDGF1 protein was lyophilized from a 0.2µm filtered solution containing no additives or preservatives.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Bio-activity: In a functional ELISA, immobilized recombinant human Activin RIB/Fc chimera receptor (0.2 µg/mL) will bind TDGF1 with linear range of 0.8 to 100 ng/ml.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized TDGF1 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Amino acid sequence: LGHQEFARPS RGYLAFRDDS IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD GLVMDEHLVA SRTPELPPS.
• Storage: Lyophilized TDGF1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TDGF1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Tag: Non
• Protein length: 31-169 a.a.

Gene Information

• Gene Name: TDGF1 teratocarcinoma-derived growth factor 1 [ Homo sapiens ]
• Official Symbol: TDGF1
• Synonyms: TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; Cripto-1; Epidermal growth factor-like cripto protein CR1; Cripto-1 growth factor
• Gene ID: 6997
• mRNA Refseq: NM_003212
• Protein Refseq: NP_003203
• MIM: 187395
• UniProt ID: P13385
• Chromosome Location: 3p21.31
• Function: growth factor activity

Reviews

01/13/2020

the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of TDGF1 protein in trials.

03/26/2018

manufacturers often have a wealth of knowledge and expertise in the field of TDGF1 protein research.

08/29/2017

They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of TDGF1 protein in their studies.

Q&As

Is TDGF1 associated with any genetic disorders?

Mutations in the TDGF1 gene have been linked to certain congenital disorders. Understanding these genetic associations can provide insights into the underlying mechanisms of these conditions.

How does TDGF1 influence neurodevelopment?

TDGF1 has been found to play a role in neural development. It is involved in the specification of neural cell fate and the formation of the neural tube during embryogenesis.

Can TDGF1 be a target for drug development?

Yes, efforts are underway to develop drugs that modulate TDGF1 activity. Targeting TDGF1 could potentially lead to novel therapies for conditions related to cell growth and differentiation.

In what ways does TDGF1 contribute to stem cell biology?

TDGF1 is involved in the maintenance of pluripotency in embryonic stem cells. Understanding its role could enhance our ability to control and manipulate stem cells for therapeutic purposes.

How can TDGF1 be utilized in cancer diagnostics?

Researchers are exploring the use of TDGF1 as a biomarker for certain cancers. Detection of elevated TDGF1 levels in patient samples may aid in early cancer diagnosis.