TLR2

  • Official Full Name

    toll-like receptor 2

  • Overview

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
  • Synonyms

    TLR2; toll-like receptor 2; TIL4; CD282; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bison bison (American bison) (Bos bison)
  • Bos indicus (Zebu)
  • Capra ibex (Ibex)
  • Giraffa camelopardalis (Giraffe)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Ovis aries (Sheep)
  • Pan paniscus (Pygmy chimpanzee) (Bonobo)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cells
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR2-529H Active Recombinant Human TLR2 Protein, His-tagged Mammalian cells His Glu21-Leu590
Human TLR2-0389H Active Recombinant Human TLR2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human TLR2-744H Recombinant Human TLR2 protein, His-tagged E.coli His Pro47~Gly245 (Accession # O60603)
Human TLR2-3258H Recombinant Human TLR2, GST-tagged E.coli GST 240-590aa
Human TLR2-745H Recombinant Human TLR2 protein, His-tagged E.coli His Phe644~Ser784 (Accession # O60603)
Human TLR2-30423TH Recombinant Human TLR2 protein, GST-tagged Wheat Germ GST
Human TLR2-182H Recombinant Human TLR2 protein, His-tagged Insect Cells His Met1-Arg587
Human TLR2-439HCL Recombinant Human TLR2 cell lysate Insect Cell N/A
Human TLR2-3358H Recombinant Human TLR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TLR2-151H Recombinant Human TLR2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human TLR2-1106H Recombinant Human TLR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TLR2-140H Recombinant Human TLR2 Protein, His-tagged E.coli His
Human TLR2-420H Recombinant Human TLR2 Protein, His-tagged E.coli N-His Glu21-Thr588
Human TLR2-3588H Recombinant Human TLR2 protein, His-SUMO-tagged E.coli His-SUMO 19-588aa
Human TLR2-2869H Recombinant Human TLR2 protein, His-tagged E.coli His 610-732 aa
Human TLR2-2204H Recombinant Human TLR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TLR2-1095HFL Recombinant Full Length Human TLR2 Protein, C-Flag-tagged Mammalian cells Flag
Human TLR2-5135H Recombinant Human TLR2 Protein (Met1-Arg587), C-His tagged Mammalian cells C-His Met1-Arg587
Human TLR2-2204H-B Recombinant Human TLR2 Protein Pre-coupled Magnetic Beads HEK293
Human TLR2-1473H Recombinant Human TLR2 Protein (Glu21-Leu590), N-His tagged E.coli N-His Glu21-Leu590
Human TLR2-5136H Recombinant Human TLR2 Protein (Met1-Leu590), C-His tagged Mammalian cells C-His Met1-Leu590
Mouse Tlr2-7396M Recombinant Mouse Tlr2 protein, His-tagged Insect Cells His Met1-Gln587
Mouse Tlr2-746M Recombinant Mouse Tlr2 protein, His & T7-tagged E.coli His/T7 Gln25~Pro250 (Accession # Q9QUN7)
Mouse TLR2-001MCL Recombinant Mouse TLR2 cell lysate Insect Cell N/A
Mouse Tlr2-6452M Recombinant Mouse Tlr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Tlr2-747R Recombinant Rat Tlr2 protein, His & GST-tagged E.coli His/GST Cys595~Thr760 (Accession # E9PTD9)
Rat Tlr2-7498R Recombinant Rat Tlr2 protein, His-tagged Insect Cells His Met1-Gln587
Rat TLR2-001RCL Recombinant Rat TLR2 cell lysate Insect Cell N/A
Rhesus monkey TLR2-1667R Recombinant Rhesus Monkey TLR2 Protein HEK293 N/A
Rhesus monkey TLR2-1668R Recombinant Rhesus Monkey TLR2 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TLR2-1669R Recombinant Rhesus Monkey TLR2 Protein, hIgG4-tagged HEK293 hIgG4
Bison bison (American bison) (Bos bison) RFL22776BF Recombinant Full Length Bison Bison Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Bos indicus (Zebu) RFL13548BF Recombinant Full Length Bos Indicus Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Capra ibex (Ibex) RFL24172CF Recombinant Full Length Capra Ibex Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Giraffa camelopardalis (Giraffe) RFL10018GF Recombinant Full Length Giraffa Camelopardalis Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Gorilla gorilla gorilla (Western lowland gorilla) RFL20689GF Recombinant Full Length Gorilla Gorilla Gorilla Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Homo sapiens (Human) RFL7415HF Recombinant Full Length Human Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (21-784aa)
Macaca mulatta (Rhesus macaque) RFL23269MF Recombinant Full Length Macaca Mulatta Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Ovis aries (Sheep) RFL2568OF Recombinant Full Length Sheep Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Pan paniscus (Pygmy chimpanzee) (Bonobo) RFL10330PF Recombinant Full Length Pan Paniscus Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Pan troglodytes (Chimpanzee) RFL14419PF Recombinant Full Length Pan Troglodytes Toll-Like Receptor 2(Tlr2) Protein, His-Tagged E.coli expression system His Full Length (21-784)
Rhesus Macaque TLR2-4731R Recombinant Rhesus monkey TLR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR2-4545R Recombinant Rhesus Macaque TLR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR2-4545R-B Recombinant Rhesus Macaque TLR2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TLR2-12078Z Recombinant Zebrafish TLR2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TLR2 involved in several pathways and played different roles in them. We selected most pathways TLR2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTUBB;ITGB3;EEA1;ATP6AP1B;MPO;ATP6V0E1;TFRC;TUBA8L;FCGR3A
PIK-Akt signaling pathwayIFNA5;RPS6KB1;FGF11;EPO;IFNA21;PPP2R2A;LPAR2;GNB4;COL6A5
Toll-like receptor signaling pathwayTICAM2;RIPK1;MAPK12;IFNA16;PIK3CB;RAC1;PIK3R2;MAPK8B;TLR2
LegionellosisCASP1;RELA;SAR1B;TLR2;EEF1A1;ITGAM;RAB1A;Casp3;NAIP1
LeishmaniasisItgam&Itgb2;NCF4;MARCKSL1;HLA-DRB1;H2-AA;MAPK3;NFKB1;IL4;IL12B
Chagas disease (American trypanosomiasis)IL1B2;PIK3R1;CD3E;IRAK1;PLCB4;C3;GNAI1;TNF;SMAD2
MalariaITGAL;Ccl12;SDC1;GYPB;CD81;CCL2;CSF3;TLR9;SELP
ToxoplasmosisHLA-DPB1;LAMC2;HLA-DQB1;NFKBIA;HLA-DOB;MAP2K3;IFNG;HLA-DRB5;HSPA6
AmoebiasisPRKACG;SERPINB3C;ACTN2;COL3A1;IL1R1;AASS;SERPINB10;COL24A1;PIK3CB
TuberculosisIL10RA;MYD88;NOS2;BAD;KSR1;NFYB;RAB5C;CLEC4M;HLA-DRB4
Hepatitis BCCNE1;PIK3CB;DDB2;TGFBR1;CREB3L3;IFNA12;CCNA2;RELA;Ifna11
MeaslesIL6;TBK1;CD209C;TLR2;HSPA2;IFNA12;CCND1;FASLG;MSN
Herpes simplex infectionCSNK2A2;STAT1;SKP2;OAS3;CUL1B;TRAF3;TAF13;SRSF9;IKBKE
Proteoglycans in cancerFZD2;Casp3;CCND1;FGFR1;VTN;ITGA2;WNT7B;CAMK2D;MTOR
Inflammatory bowel disease (IBD)STAT6;HLA-DPB1;TGFB3;Il23a;HLA-DQA2;HLA-DRB3;TLR4;IL18R1;IL4R
Rheumatoid arthritisITGAL;TNFRSF11A;LTB;TNFSF11;ATP6V0E2;CXCL1;TLR2;H2-AB1;IFNG

TLR2 has several biochemical functions, for example, Toll-like receptor binding, diacyl lipopeptide binding, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR2 itself. We selected most functions TLR2 had, and list some proteins which have the same functions with TLR2. You can find most of the proteins on our site.

Function Related Protein
Toll-like receptor bindingTOLLIP;TLR2
diacyl lipopeptide bindingTLR6;TLR2
lipopolysaccharide bindingTREM2;CATHL3;RNASE7;SPON2;BPIFC;P2RX7;BPI;TLR4;PSMB4
lipopolysaccharide receptor activityTLR2;LY96;TLR4;SCARB1;PTAFR
lipoteichoic acid bindingCD6;LBP;TREM2;TLR2;CD14
peptidoglycan bindingRNASE7;PGLYRP3;PGLYRP4;PGLYRP2;TREM2;TLR2;NOD1;PGLYRP1;NLRP3
protein bindingC19orf73;C1QTNF2;KCNA4;GJA4;CD4;TXNL4A;C16orf53;EXOC1;RAPGEF6
protein heterodimerization activitySMC1A;TAF9;ALX4;P4HB;TCF3A;NTSR1;BIRC5;H2AFJ;IKZF1
receptor activityVMN1R49;F2RL1.2;JMJD6;EDAR;IGF2R;ITGB1B.1;NLGN4A;DERL1;EIF2D
signaling pattern recognition receptor activityDMBT1;MARCO;FCN1;COLEC12;TLR2;TRIM5;CLEC7A
transmembrane signaling receptor activityERBB2;CLDN4;P2RX6;MRC1;LILRA1;GABRQ;OR4C12;BAI2;FZD7B
triacyl lipopeptide binding

TLR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR2.

PAUF; EGFR; MYD88; BGN; PIK3R1; ppe68; PE35; ATG16L1; TGFB1; FBP1; TMOD1; AKT1; STX17; MAP2K1; SMAD1; ANP32B

Research Area

Related articles

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).
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