TLR2
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Official Full Name
toll-like receptor 2
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Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] -
Synonyms
TLR2; toll-like receptor 2; TIL4; CD282; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bison bison (American bison) (Bos bison)
- Bos indicus (Zebu)
- Capra ibex (Ibex)
- Giraffa camelopardalis (Giraffe)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Ovis aries (Sheep)
- Pan paniscus (Pygmy chimpanzee) (Bonobo)
- Pan troglodytes (Chimpanzee)
- Rat
- Rhesus Macaque
- Rhesus monkey
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cells
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- DYKDDDDK
- Flag
- GST
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|GST
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
TLR2 involved in several pathways and played different roles in them. We selected most pathways TLR2 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | TUBB;ITGB3;EEA1;ATP6AP1B;MPO;ATP6V0E1;TFRC;TUBA8L;FCGR3A |
| PIK-Akt signaling pathway | IFNA5;RPS6KB1;FGF11;EPO;IFNA21;PPP2R2A;LPAR2;GNB4;COL6A5 |
| Toll-like receptor signaling pathway | TICAM2;RIPK1;MAPK12;IFNA16;PIK3CB;RAC1;PIK3R2;MAPK8B;TLR2 |
| Legionellosis | CASP1;RELA;SAR1B;TLR2;EEF1A1;ITGAM;RAB1A;Casp3;NAIP1 |
| Leishmaniasis | Itgam&Itgb2;NCF4;MARCKSL1;HLA-DRB1;H2-AA;MAPK3;NFKB1;IL4;IL12B |
| Chagas disease (American trypanosomiasis) | IL1B2;PIK3R1;CD3E;IRAK1;PLCB4;C3;GNAI1;TNF;SMAD2 |
| Malaria | ITGAL;Ccl12;SDC1;GYPB;CD81;CCL2;CSF3;TLR9;SELP |
| Toxoplasmosis | HLA-DPB1;LAMC2;HLA-DQB1;NFKBIA;HLA-DOB;MAP2K3;IFNG;HLA-DRB5;HSPA6 |
| Amoebiasis | PRKACG;SERPINB3C;ACTN2;COL3A1;IL1R1;AASS;SERPINB10;COL24A1;PIK3CB |
| Tuberculosis | IL10RA;MYD88;NOS2;BAD;KSR1;NFYB;RAB5C;CLEC4M;HLA-DRB4 |
| Hepatitis B | CCNE1;PIK3CB;DDB2;TGFBR1;CREB3L3;IFNA12;CCNA2;RELA;Ifna11 |
| Measles | IL6;TBK1;CD209C;TLR2;HSPA2;IFNA12;CCND1;FASLG;MSN |
| Herpes simplex infection | CSNK2A2;STAT1;SKP2;OAS3;CUL1B;TRAF3;TAF13;SRSF9;IKBKE |
| Proteoglycans in cancer | FZD2;Casp3;CCND1;FGFR1;VTN;ITGA2;WNT7B;CAMK2D;MTOR |
| Inflammatory bowel disease (IBD) | STAT6;HLA-DPB1;TGFB3;Il23a;HLA-DQA2;HLA-DRB3;TLR4;IL18R1;IL4R |
| Rheumatoid arthritis | ITGAL;TNFRSF11A;LTB;TNFSF11;ATP6V0E2;CXCL1;TLR2;H2-AB1;IFNG |
TLR2 has several biochemical functions, for example, Toll-like receptor binding, diacyl lipopeptide binding, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR2 itself. We selected most functions TLR2 had, and list some proteins which have the same functions with TLR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Toll-like receptor binding | TOLLIP;TLR2 |
| diacyl lipopeptide binding | TLR6;TLR2 |
| lipopolysaccharide binding | TREM2;CATHL3;RNASE7;SPON2;BPIFC;P2RX7;BPI;TLR4;PSMB4 |
| lipopolysaccharide receptor activity | TLR2;LY96;TLR4;SCARB1;PTAFR |
| lipoteichoic acid binding | CD6;LBP;TREM2;TLR2;CD14 |
| peptidoglycan binding | RNASE7;PGLYRP3;PGLYRP4;PGLYRP2;TREM2;TLR2;NOD1;PGLYRP1;NLRP3 |
| protein binding | C19orf73;C1QTNF2;KCNA4;GJA4;CD4;TXNL4A;C16orf53;EXOC1;RAPGEF6 |
| protein heterodimerization activity | SMC1A;TAF9;ALX4;P4HB;TCF3A;NTSR1;BIRC5;H2AFJ;IKZF1 |
| receptor activity | VMN1R49;F2RL1.2;JMJD6;EDAR;IGF2R;ITGB1B.1;NLGN4A;DERL1;EIF2D |
| signaling pattern recognition receptor activity | DMBT1;MARCO;FCN1;COLEC12;TLR2;TRIM5;CLEC7A |
| transmembrane signaling receptor activity | ERBB2;CLDN4;P2RX6;MRC1;LILRA1;GABRQ;OR4C12;BAI2;FZD7B |
| triacyl lipopeptide binding |
TLR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR2.
PAUF; EGFR; MYD88; BGN; PIK3R1; ppe68; PE35; ATG16L1; TGFB1; FBP1; TMOD1; AKT1; STX17; MAP2K1; SMAD1; ANP32B
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