Tlr4

  • Official Full Name

    toll-like receptor 4

  • Overview

    Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
  • Synonyms

    TLR4; toll-like receptor 4; Lps; Ly87; Ran/M1; Rasl2-8; lipopolysaccharide response;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Goat
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Baculovirus-Insect cells
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • His
  • Strep
  • DYKDDDDK
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Ser|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR4-296H Active Recombinant Human TLR4/LY96 Complex Protein, His-tagged Mammalian cells His
Human TLR4-886H Active Recombinant Human TLR4 Protein, Ser & His-tagged Mammalian cells Ser/His Glu24-Lys631
Human TLR4-292H Recombinant Human TLR4, GST-tagged Wheat Germ GST
Human TLR4-29825TH Recombinant Human TLR4 Wheat Germ N/A 78 amino acids
Human TLR4-7275H Recombinant Human TLR4, His tagged Insect Cells His Met1-Lys631
Human TLR4-7618H Recombinant Human TLR4 protein, His & T7-tagged E.coli His/T7 Cys29~Leu253 (Accession # O00206)
Human TLR4-7617H Recombinant Human TLR4 protein, His & S-tagged E.coli His/S Phe326~Ile634 (Accession # O00206)
Human TLR4-291H Recombinant Human TLR4, GST-tagged Wheat Germ GST
Human TLR4-290H Active Recombinant Human TLR4 Protein, His-tagged Mammalian cells His
Human TLR4-293H Recombinant Human TLR4 Wheat Germ N/A
Human TLR4-289H Recombinant Human TLR4, MYC/DDK-tagged HEK293 Myc/DDK
Human TLR4-402HCL Recombinant Human TLR4 cell lysate Insect Cell N/A
Human TLR4-524HF Recombinant Full Length Human TLR4 Protein, GST-tagged In Vitro Cell Free System GST 639 amino acids
Human TLR4-73H Recombinant Human TLR4 Protien, Fc-tagged HEK293 Fc Glu 24 - Lys 631
Human TLR4-2447H Recombinant Human TLR4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TLR4-2262H Recombinant Human TLR4 protein, His-tagged Insect Cell His 27-631aa
Human TLR4-526HF Recombinant Full Length Human TLR4 Protein In Vitro Cell Free System 46 amino acids
Human TLR4-2205H-B Recombinant Human TLR4 Protein Pre-coupled Magnetic Beads HEK293
Human TLR4-652H Recombinant Human TLR4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human TLR4-3589H Recombinant Human TLR4 protein, His-tagged E.coli His 27-631aa
Human TLR4-614HFL Recombinant Full Length Human TLR4 Protein, C-Flag-tagged Mammalian cells Flag
Human TLR4-5138H Recombinant Human TLR4 Protein (Met1-Lys631), C-His tagged Mammalian cells C-His Met1-Lys631
Human TLR4-2205H Recombinant Human TLR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TLR4-141H Recombinant Human TLR4 Protein, His-tagged E.coli His
Human TLR4-1487H Recombinant Human TLR4 Protein (Glu24-Lys631), N-His tagged E.coli N-His Glu24-Lys631
Human TLR4-5139H Recombinant Human TLR4 Protein (Met1-Lys631), C-Fc tagged Mammalian cells C-Fc Met1-Lys631
Human TLR4-0257H Recombinant Human TLR4 Protein (Glu24-Lys631), C-Strep-tagged Baculovirus-Insect cells C-Strep Glu24-Lys631
Human TLR4-40689H Active Recombinant Human TLR4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Mouse Tlr4-2432M Recombinant Mouse Toll-like Receptor 4, Fc Chimera Human Cell Fc
Mouse Tlr4-7619M Recombinant Mouse Tlr4 protein, His & S-tagged E.coli His/S Asn26~Glu269 (Accession # Q9QUK6)
Mouse TLR4-16826M Recombinant Mouse TLR4 Protein Mammalian Cell His
Mouse Tlr4-5532M Recombinant Mouse Tlr4 protein, His-tagged Yeast His 26-638aa
Mouse TLR4-9237M-B Recombinant Mouse TLR4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tlr4-6453M Recombinant Mouse Tlr4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tlr4-02M Active Recombinant Mouse Tlr4 Protein, Fc-tagged CHO Fc 26-629
Mouse TLR4-9237M Recombinant Mouse TLR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tlr4-7620R Recombinant Rat Tlr4 protein, His-tagged E.coli His His49~Gln247
Rat TLR4-6084R Recombinant Rat TLR4 Protein Mammalian Cell His
Rat Tlr4-2401R Recombinant Rat Tlr4 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 26-638aa
Rat TLR4-5741R-B Recombinant Rat TLR4 Protein Pre-coupled Magnetic Beads HEK293
Rat TLR4-5741R Recombinant Rat TLR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey TLR4-1673R Recombinant Rhesus Monkey TLR4 Protein HEK293 N/A
Rhesus monkey TLR4-1674R Recombinant Rhesus Monkey TLR4 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TLR4-1675R Recombinant Rhesus Monkey TLR4 Protein, hIgG4-tagged HEK293 hIgG4
Goat TLR4-421G Recombinant Goat TLR4 Protein, His-tagged E.coli N-His Trp26-Leu253
Rhesus Macaque TLR4-4733R Recombinant Rhesus monkey TLR4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR4-4547R Recombinant Rhesus Macaque TLR4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR4-4547R-B Recombinant Rhesus Macaque TLR4 Protein Pre-coupled Magnetic Beads HEK293
Chicken TLR4-2396C Recombinant Chicken TLR4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tlr4 Related Research Area

Tlr4 involved in several pathways and played different roles in them. We selected most pathways Tlr4 participated on our site, such as NF-kappa B signaling pathway, HIF- signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayPIAS4;IRAK4;TNFSF14;XIAP;TNFRSF11A;CCL19;ATM;TRIM25;LRDD
HIF- signaling pathwayPDHB;NOS2;GAPDH;EP300;PIK3R5;NOX1;EGLN1;PGK1;TF
PhagosomeBLB1;FCGR2C;CD209;SEC22BB;MRC1;STX12;THBS4;LAMP1;SEC61A1
PIK-Akt signaling pathwayTHBS4;PPP2R1B;TCL1B1;IFNA13;GYS2;PPP2R1A;MCL1;Fasl;RHEB
Toll-like receptor signaling pathwayTLR5;PIK3R3;PIK3CG;MYD88;TMED7-TICAM2;MAPK10;MAP2K2B;MAPK12;RELA
Pathogenic Escherichia coli infectionTLR5;TUBAL3;TUBB6;RHOA;KRT18;FYN;TUBB2A;ARPC5L;ACTB
Salmonella infectionARPC5A;TLR4BA;RHOG;CD14;RAC1;WASL;DYNC2H1;RHOGB;RILP
PertussisMAPK3;C1QA;IRF1;ITGB2L;C5;CXCL5;SERPING1;IL1B;MYD88
LegionellosisITGB2;SAR1B;C3;Itgam&Itgb2;SEC22B;HSPD1;HSPA2;PYCARD;ITGB2L
LeishmaniasisELK1;NFKBIB;TNF;FCGR1A;NOS2;TGFB2;IL1B;PTPN6;TLR4
Chagas disease (American trypanosomiasis)SERPINE1;TGFB3;SMAD2;IFNGR1;PLCB3;CASP8;TNF;Ccl12;BDKRB2
MalariaSDC2;CD40;IL18;KLRK1;CSF3;IL12A;HBB-B1;IL1B;TGFB1
ToxoplasmosisLAMB2;IRAK4;BIRC7;HLA-DPA1;BIRC3;MAPK10;PIK3R2;HLA-DQA1;HLA-DOB
AmoebiasisCSF2;AASS;TLR2;LAMC3;RAB5C;PIK3R1;CD1D;ACTN3;GNA15
TuberculosisHLA-DQA2;ARHGEF12;IRAK2;LAMP1;CD74;FCGR3;CYCS;EP300;FCGR1A
Hepatitis BMAPK1;BAD;PIK3CB;RELA;BCL2;CCNA2;NFATC4;IFNA7;MAP2K4
MeaslesIRF7;IFNA10;TACR1;CCND3;IL2RG;HSPA1B;TBK1;FASLG;CD46
Influenza ACCL5;MAPK12;IL8L1;HLA-DRB4;RELA;IFNA10;FDPS;LOC100033925;TNF
Proteoglycans in cancerCBLC;WNT4;FZD6;HGF;MET;ACTB;TGFB1;IGF1R;FASLG
Inflammatory bowel disease (IBD)HLA-DQA1;STAT4;HLA-DPB1;IL12RB2;IL23;IL4R;HLA-DRB4;IFNG;IL12RB1
Rheumatoid arthritisHLA-DRB1;HLA-DOA;CXCL12;HLA-DRA;CXCL6;ATP6V0E2;ACP5;ATP6V0D1;ITGB2

Tlr4 has several biochemical functions, for example, lipopolysaccharide binding, lipopolysaccharide receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr4 itself. We selected most functions Tlr4 had, and list some proteins which have the same functions with Tlr4. You can find most of the proteins on our site.

Function Related Protein
lipopolysaccharide bindingRNASE7;LBP;KIAA0644;HMGB1;P2RX7;BPIFC;SCARB1;TLR4;CD14
lipopolysaccharide receptor activitySCARB1;TLR4;LY96;PTAFR;TLR2
protein bindingAP1M1;CLC;SOCS3;SEPT12;SERBP1;MAPK15;NDNL2;ADAM10;MLLT6
receptor activityNLGN3A;CLEC4E;VMN1R47;CADM3;SLC20A1;NLGN4X;ITGB3B;TREM1;GRIN2BB
transmembrane signaling receptor activityGPR126;IL1R1;FCAMR;KLRF1;EVI2A;BAI2;RYK;OR115-6;OR12D3

Tlr4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr4.

LY96; TIRAP; o76552_acavi; eritoran tetrasodium; BGN; PAUF; LY96; EGFR; HMGB1; F2RL1; TICAM2

  • Q&As
  • Reviews

Q&As (5)

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How does TLR4 signaling intersect with the nuclear factor-kappa B (NF-κB) pathway? 11/20/2021

TLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.

Can you explain the molecular events following TLR4 activation upon ligand binding? 08/14/2020

Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.

What is the role of the TLR4 signaling pathway in innate immunity? 02/18/2019

The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.

Can you elaborate on the crosstalk between TLR4 and other pattern recognition receptors (PRRs)? 10/02/2018

TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.

Can you describe the molecular structure of TLR4 and its functional domains? 04/23/2018

TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.

Customer Reviews (3)

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Reviews
12/29/2020

    Precision in every experiment—this product is a game-changer for us.

    04/07/2019

      Timely delivery is key, and this product arrived on schedule.

      08/06/2018

        Exceptional customer service—knowledgeable staff guided us through the selection process.

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