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Recombinant Rhesus Monkey TLR4 Protein, hIgG4-tagged

Cat.No. : TLR4-1675R
Product Overview : Recombinant Rhesus monkey TLR4 Protein (NP_001032169 ( aa.24-631)) was expressed in human HEK293 cells with hIgG4 tag.
  • Specification
  • Gene Information
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Source : HEK293
Species : Rhesus monkey
Tag : hIgG4
Form : PBS, pH7.4.
Purity : > 95 %
Applications : ELISA; WB; Immunogen
Storage : -80 centigrade, Avoid freeze/thaw cycle.
Concentration : 1 mg/mL
Gene Name : TLR4 toll like receptor 4 [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : TLR4
Synonyms : TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10;
Gene ID : 574360
mRNA Refseq : NM_001037092.1
Protein Refseq : NP_001032169

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TLR4 signaling intersect with the nuclear factor-kappa B (NF-κB) pathway? 11/20/2021

TLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.

Can you explain the molecular events following TLR4 activation upon ligand binding? 08/14/2020

Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.

What is the role of the TLR4 signaling pathway in innate immunity? 02/18/2019

The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.

Can you elaborate on the crosstalk between TLR4 and other pattern recognition receptors (PRRs)? 10/02/2018

TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.

Can you describe the molecular structure of TLR4 and its functional domains? 04/23/2018

TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.

Customer Reviews (3)

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Reviews
12/29/2020

    Precision in every experiment—this product is a game-changer for us.

    04/07/2019

      Timely delivery is key, and this product arrived on schedule.

      08/06/2018

        Exceptional customer service—knowledgeable staff guided us through the selection process.

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