Recombinant Human TLR4 Protein, His-tagged
Cat.No. : | TLR4-141H |
Product Overview : | Recombinant Human TLR4 Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM) . This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB, which normally maintains NF-κB in an inactive state by sequestering it in the cytoplasm. Toll-like receptor 4 (TLR4) functions in association with MD-2 in the recognition and initiation of immune responses elicited by lipopolysaccharide (LPS) of Gram-negative bacteria. TLR4 triggers the activation of NF-κB, IRF-3, and MAPK pathways leading to the production of inflammatory cytokines. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~60 kDa |
AA Sequence : | ESWEPCVEVVPNITYQCMELNFYKI PDNLPFSTKNLDLSFNPLRHLGSYS FFSFPELQVLDLSRCEIQTIEDGAY QSLSHLSTLILTGNPIQSLALGAFS GLSSLQKLVAVETNLASLENFPIGH LKTLKELNVAHNLIQSFKLPEYFSN LTNLEHLDLSSNKIQSIYCTDLRVL HQMPLLNLSLDLSLNPMNFIQPGAF KEIRLHKLTLRNNFDSLNVMKTCIQ GLAGLEVHRLVLGEFRNEGNLEKFD KSALEGLCNLTIEEFRLAYLDYYLD DIIDLFNCLTNVSSFSLVSVTIERV KDFSYNFGWQHLELVNCKFGQFPTL KLKSLKRLTFTSNKGGNAFSEVDLP SLEFLDLSRNGLSFKGCCSQSDFGT TSLKYLDLSFNGVITMSSNFLGLEQ LEHLDFQHSNLKQMSEFSVFLSLRN LIYLDISHTHTRVAFNGIFNGLSSL EVLKMAGNSFQENFLPDIFTELRNL TFLDLSQCQLEQLSPTAFNSLSSLQ VLNMSHNNFFSLDTFPYKCLNSLQV LDYSLNHIMTSKKQELQHFPSSLAF LNLTQNDFACTCEHQSFLQWIKDQR QLLVEVERMECATPSDKQGMPVLSL NITCQMNK |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | TLR4 toll-like receptor 4 [ Homo sapiens (human) ] |
Official Symbol : | TLR4 |
Synonyms : | TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10; |
Gene ID : | 7099 |
mRNA Refseq : | NM_003266 |
Protein Refseq : | NP_003257 |
MIM : | 603030 |
UniProt ID : | O00206 |
Products Types
◆ Recombinant Protein | ||
TLR4-9237M | Recombinant Mouse TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TLR4-290H | Active Recombinant Human TLR4 Protein, His-tagged | +Inquiry |
TLR4-2205H | Recombinant Human TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Tlr4-02M | Active Recombinant Mouse Tlr4 Protein, Fc-tagged | +Inquiry |
TLR4-5741R | Recombinant Rat TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TLR4-402HCL | Recombinant Human TLR4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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