| Description : |
The protein encoded by this gene is a member of the Toll-likereceptor (TLR) family which plays a fundamental role in pathogen recognitionand activation of innate immunity. TLRs are highly conserved from Drosophilato humans and share structural and functional similarities. They recognizepathogen-associated molecular patterns (PAMPs) that are expressed oninfectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibit different patternsof expression. This receptor is most abundantly expressed in placenta, and inmyelomonocytic subpopulation of the leukocytes. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
99.7kDa |
| Protein Length : |
639 amino acids |
| AA Sequence : |
MPLLNLSLDLSLNPMNFIQPGAFKE IRLHKLTLRNNFDSLNVMKTCIQGL AGLEVHRLVLGEFRNEGNLEKFDKS ALEGLCNLTIEEFRLAYLDYYLDDI IDLFNCLTNVSSFSLVSVTIERVKD FSYNFGWQHLELVNCKFGQFPTLKL KSLKRLTFTSNKGGNAFSEVDLPSL EFLDLSRNGLSFKGCCSQSDFGTTS LKYLDLSFNGVITMSSNFLGLEQLE HLDFQHSNLKQMSEFSVFLSLRNLI YLDISHTHTRVAFNGIFNGLSSLEV LKMAGNSFQENFLPDIFTELRNLTF LDLSQCQLEQLSPTAFNSLSSLQVL NMSHNNFFSLDTFPYKCLNSLQVLD YSLNHIMTSKKQELQHFPSSLAFLN LTQNDFACTCEHQSFLQWIKDQRQL LVEVERMECATPSDKQGMPVLSLNI TCQMNKTIIGVSVLSVLVVSVVAVL VYKFYFHLMLLAGCIKYGRGENIYD AFVIYSSQDEDWVRNELVKNLEEGV PPFQLCLHYRDFIPGVAIAANIIHE GFHKSRKVIVVVSQHFIQSRWCIFE YEIAQTWQFLSSRAGIIFIVLQKVE KTLLRQQVELYRLLSRNTYLEWEDS VLGRHIFWRRLRKALLDGKSWNPEG TVGTGCNWQEATSI |
| Purity : |
GlutathioneSepharose 4 Fast Flow |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
