| Description : |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
93.2 kDa |
| AA Sequence : |
MSASRLAGTLIPAMAFLSCVRPESW EPCVEVVPNITYQCMELNFYKIPDN LPFSTKNLDLSFNPLRHLGSYSFFS FPELQVLDLSRCEIQTIEDGAYQSL SHLSTLILTGNPIQSLALGAFSGLS SLQKLVAVETNLASLENFPIGHLKT LKELNVAHNLIQSFKLPEYFSNLTN LEHLDLSSNKIQSIYCTDLRVLHQM PLLNLSLDLSLNPMNFIQPGAFKEI RLHKLTLRNNFDSLNVMKTCIQGLA GLEVHRLVLGEFRNEGNLEKFDKSA LEGLCNLTIEEFRLAYLDYYLDDII DLFNCLTNVSSFSLVSVTIERVKDF SYNFGWQHLELVNCKFGQFPTLKLK SLKRLTFTSNKGGNAFSEVDLPSLE FLDLSRNGLSFKGCCSQSDFGTTSL KYLDLSFNGVITMSSNFLGLEQLEH LDFQHSNLKQMSEFSVFLSLRNLIY LDISHTHTRVAFNGIFNGLSSLEVL KMAGNSFQENFLPDIFTELRNLTFL DLSQCQLEQLSPTAFNSLSSLQVLN MSHNNFFSLDTFPYKCLNSLQVLDY SLNHIMTSKKQELQHFPSSLAFLNL TQNDFACTCEHQSFLQWIKDQRQLL VEVERMECATPSDKQGMPVLSLNIT CQMNKTIIGVSVLSVLVVSVVAVLV YKFYFHLMLLAGCIKYGRGENIYDA FVIYSSQDEDWVRNELVKNLEEGVP PFQLCLHYRDFIPGVAIAANIIHEG FHKSRKVIVVVSQHFIQSRWCIFEY EIAQTWQFLSSRAGIIFIVLQKVEK TLLRQQVELYRLLSRNTYLEWEDSV LGRHIFWRRLRKALLDGKSWNPEGT VGTGCNWQEATSITRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
