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Official Full Name transmembrane protein 173
Background STING (MITA/MYPS/TMEM173) is a recently identified adaptor found to be a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA . It is ubiquitously expressed, resides in the ER, and has five transmembrane regions. Detecti
Synonyms TMEM173; transmembrane protein 173; FLJ38577; NET23; hMITA; hSTING; mediator of IRF3 activation; endoplasmic reticulum IFN stimulator; stimulator of interferon genes protein; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stim
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TMEM173-1436H Recombinant Human TMEM173 protein, His-tagged E.coli His
    Human TMEM173-284H Recombinant Human TMEM173 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TMEM173-3281H Recombinant Human TMEM173, GST-tagged E.coli GST
    Human TMEM173-3282H Recombinant Human TMEM173 protein, His-tagged E.coli His
    Human TMEM173-3290H Recombinant Human TMEM173 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TMEM173-988HCL Recombinant Human TMEM173 293 Cell Lysate HEK293 N/A
    Mouse Tmem173-1437M Recombinant Mouse Tmem173 protein, His-tagged E.coli His
    Mouse TMEM173-16951M Recombinant Mouse TMEM173 Protein Mammalian Cell His
    Rat Tmem173-1438R Recombinant Rat Tmem173 protein, His & T7-tagged E.coli His/T7
    Zebrafish TMEM173-8322Z Recombinant Zebrafish TMEM173 Mammalian Cell His

    tmem173 involved in several pathways and played different roles in them. We selected most pathways tmem173 participated on our site, such as RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with tmem173 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RIG-I-like receptor signaling pathway RNF125; IFNK; MAPK8A; TMEM173; NFKBIB; IFNA16; IFNA3; NFKB1; TNF; MAPK8
    Cytosolic DNA-sensing pathway NFKB1; POLR1C; IFNA5; POLR2F; OSTN; RIPK1; IFNA14; POLR2K; IFNA16; NFKBIAB

    tmem173 has several biochemical functions, for example, cyclic-GMP-AMP binding, cyclic-di-GMP binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tmem173 itself. We selected most functions tmem173 had, and list some proteins which have the same functions with tmem173. You can find most of the proteins on our site.

    Function Related Protein
    cyclic-GMP-AMP binding TMEM173
    cyclic-di-GMP binding TMEM173
    identical protein binding EIF2AK3; CLDN10; SHARPIN; PRDX3; POLG2; SNCA; ZHX2; GLUD1; SYT9; TRA@
    protein binding PRKACB; ZNF263; EXOSC1; TSC1; FGFR1; LMO3; TMED1; LYN; TAF1B; CD36
    protein homodimerization activity MYOM3; GPD1A; FAM109A; IL17F; LRRK2; NRBP1; ERBB4; PRDM6; KCNH2; CCBL2
    protein kinase binding CCNT2A; CDK5RAP1; Cd24a; PTPRK; SPDYE2; CCNY; CYLD; TMEM173; VDAC1; WAS
    transcription factor binding IGHMBP2; KEAP1B; SRF; TAF7; PPP1R13BB; CXXC5; HES1; EGR1; APBB2; ERCC3
    ubiquitin protein ligase binding HSPA1L; CUL5; UBE2O; RNF20; NDUFS2; WASH; EGR2; GSK3B; ACTG1; SMAD6

    tmem173 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tmem173 here. Most of them are supplied by our site. Hope this information will be useful for your research of tmem173.

    MAVS; STAT6; cg(2'5')_pa(3'5')p

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