TSC22D3

  • Official Full Name

    TSC22 domain family, member 3

  • Overview

    The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    TSC22D3; TSC22 domain family, member 3; TSC22 domain family protein 3; TSC22 domain family 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; DIP; Gilz; Dsip1; Tilz3; TSC-22R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSC22D3-29063TH Recombinant Human TSC22D3 Wheat Germ N/A 97 amino acids
Human TSC22D3-29062TH Recombinant Human TSC22D3 Wheat Germ N/A 200 amino acids
Human TSC22D3-3443H Recombinant Human TSC22D3, GST-tagged E.coli GST C-term-83aa
Human TSC22D3-7192H Recombinant Human TSC22 Domain Family, Member 3, His-tagged E.coli His 1-134aa
Human TSC22D3-723HCL Recombinant Human TSC22D3 293 Cell Lysate HEK293 N/A
Human TSC22D3-1810H Recombinant Human TSC22D3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TSC22D3-531HF Recombinant Full Length Human TSC22D3 Protein In Vitro Cell Free System 200 amino acids
Human TSC22D3-2265H Recombinant Human TSC22D3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TSC22D3-889HFL Recombinant Full Length Human TSC22D3 Protein, C-Flag-tagged Mammalian cells Flag
Human TSC22D3-2265H-B Recombinant Human TSC22D3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tsc22d3-694M Recombinant Mouse Tsc22d3 protein, His & T7-tagged E.coli His/T7 Met1~Val137 (Accession # Q9Z2S7)
Mouse TSC22D3-17477M Recombinant Mouse TSC22D3 Protein Mammalian Cell His
Mouse TSC22D3-9666M-B Recombinant Mouse TSC22D3 Protein Pre-coupled Magnetic Beads HEK293
Mouse TSC22D3-9666M Recombinant Mouse TSC22D3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tsc22d3-6680M Recombinant Mouse Tsc22d3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat TSC22D3-6311R Recombinant Rat TSC22D3 Protein Mammalian Cell His
Rat TSC22D3-5968R Recombinant Rat TSC22D3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TSC22D3-5968R-B Recombinant Rat TSC22D3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TSC22D3-4989R Recombinant Rhesus monkey TSC22D3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TSC22D3-4803R-B Recombinant Rhesus Macaque TSC22D3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TSC22D3-4803R Recombinant Rhesus Macaque TSC22D3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TSC22D3-10848Z Recombinant Zebrafish TSC22D3 Mammalian Cell His
Chicken TSC22D3-3512C Recombinant Chicken TSC22D3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TSC22D3 involved in several pathways and played different roles in them. We selected most pathways TSC22D3 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC22D3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportUNC79;TRPC4;FXYD3;ATP6V1G3;SCNN1D;CLCN5;WNK2;ANO5B;ANO8
Stimuli-sensing channelsTTYH1;CLCN6;TRPM6;GSDMA2;ANO5;CLIC2;ASPH;TRPA1B;CLCN4-2
Transmembrane transport of small moleculesSLC9A5;SLC43A1A;TTYH3;MCOLN2;SLC9A10;SLC5A2;SLC2A6;AQP3B;RHCG

TSC22D3 has several biochemical functions, for example, MRF binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC22D3 itself. We selected most functions TSC22D3 had, and list some proteins which have the same functions with TSC22D3. You can find most of the proteins on our site.

Function Related Protein
MRF bindingBHLHE40;KDM1A;CREBBP;TSC22D3
protein bindingITPRIPL1;Fgf15;ITGAX;SEC61G;TEX10;SH2D3C;CYSLTR2;DDX39B;C9orf142
transcription factor activity, sequence-specific DNA bindingEGR4;NFIX;AFF4;ZNF16;ZNF205;GRHL2A;HNF1B;TBX10;MAX

TSC22D3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC22D3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC22D3.

TSC22D1; MTA2; lpd; DCLK2; PLEKHF2; HPCAL4

Research Area

Related articles

Kavvoura, FK; Raimondo, A; et al. Reclassification of Diabetes Etiology in a Family With Multiple Diabetes Phenotypes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E1067-E1071(2014).
Kanthimathi, S; Jahnavi, S; et al. Glucokinase Gene Mutations (MODY 2) in Asian Indians. DIABETES TECHNOLOGY & THERAPEUTICS 16:180-185(2014).
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