Recombinant Mouse Tsc22d3 Protein, Myc/DDK-tagged

• Cat.No.: Tsc22d3-6680M
• Product Overview: Purified recombinant protein of mouse full-length TSC22 domain family, member 3 (Tsc22d3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 15.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tsc22d3 TSC22 domain family, member 3 [ Mus musculus (house mouse) ]
• Official Symbol: Tsc22d3
• Synonyms: TSC22D3; TSC22 domain family, member 3; TSC22 domain family protein 3; TSC22 domain family 3; TSC22-related inducible leucine zipper 3; TSC22-related-inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein; DIP; Gilz; Dsip1; Tilz3; TSC-22R
• Gene ID: 14605
• mRNA Refseq: NM_010286
• Protein Refseq: NP_034416
• UniProt ID: Q9Z2S7