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Official Full Name ubiquitin-conjugating enzyme E2C
Background UbcH10 in conjunction with the anaphase-promoting complex catalyzes the destruction of cyclins A and B and therefore plays an important role in the control of the cell exit from mitosis.
Synonyms UBE2C; ubiquitin-conjugating enzyme E2C; ubiquitin-conjugating enzyme E2 C; UBCH10; ubiquitin-protein ligase C; ubiquitin carrier protein C; ubiquitin carrier protein E2-C; cyclin-selective ubiquitin carrier protein; mitotic-specific ubiquitin-conjugating enzyme; dJ447F3.2
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Met
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2C-5732H Recombinant Human UBE2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UBE2C-5854H Recombinant Human UBE2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ube2c-6781M Recombinant Mouse Ube2c Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human UBE2C-04H Recombinant Human UBE2C protein E.coli N/A
    Human UBE2C-10H Recombinant Human Ubiquitin Conjugating Enzyme 10,His-tagged E.coli His
    Human UBE2C-118H Recombinant Human UBE2C E.coli N/A
    Human UBE2C-221H Recombinant Human UBE2C, His-tagged E.coli His
    Human UBE2C-3527H Recombinant Human UBE2C, GST-tagged E.coli GST
    Human UBE2C-591HCL Recombinant Human UBE2C 293 Cell Lysate HEK293 N/A
    Human UBE2C-592HCL Recombinant Human UBE2C 293 Cell Lysate HEK293 N/A
    Human UBE2C-643H Recombinant Human UBE2C Protein, His-tagged, Active E.coli His
    Human UBE2C-899H Recombinant Human UBE2C Protein, Met & His-tagged E.coli Met/His
    Human UBE2C-900H Recombinant Human UBE2C E.coli N/A
    Cynomolgus Monkey UBE2C-1072C Recombinant Cynomolgus UBE2C Protein, His-tagged Mammalian Cell His
    Zebrafish UBE2C-3585Z Recombinant Zebrafish UBE2C Mammalian Cell His

    ube2c involved in several pathways and played different roles in them. We selected most pathways ube2c participated on our site, such as APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    APC-Cdc20 mediated degradation of Nek2A NEK2; UBE2C; ANAPC10
    APC/C-mediated degradation of cell cycle proteins ANAPC10; PSMD9; UBE2C; NEK2; PSMD5; AURKB; PSMA8; CDK2; PSMD10; PSME3
    APC/C:Cdc20 mediated degradation of Cyclin B ANAPC10; UBE2C
    APC/C:Cdc20 mediated degradation of Securin UBE2C; ANAPC10; PSMA8; PSMD14; PSMD10; PSMD9; PSME3; PSMD5
    APC/C:Cdc20 mediated degradation of mitotic proteins ANAPC10; PSMD14; PSMA8; PSMD10; NEK2; PSME3; UBE2C; PSMD5; PSMD9
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 UBE2C; PSMA8; AURKB; PSMD10; PSMD14; PSMD5; PSMD9; ANAPC10; PSME3
    APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMA8; PSMD14; NEK2; PSMD5; PSMD10; PSMD9; PSME3; UBE2C; ANAPC10
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins ANAPC10; PSMD10; PSMD5; PSMD9; PSMD14; PSMA8; UBE2C; PSME3; NEK2

    ube2c has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2c itself. We selected most functions ube2c had, and list some proteins which have the same functions with ube2c. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SNX8; EDC3; PARD6A; BRMS1; AKR7A3; ZNF580; NFATC4; GPR19; SRPK1; SMNDC1
    ubiquitin conjugating enzyme activity UBE2C; UBE2R2; UBE2D4; UBE2T; UBE2Q1; UBE2D2; UBE2J1; UBE2E3; UBE2D3; CDC34
    ubiquitin protein ligase activity MGRN1; TRIM72; FBXO6; NEDD4L; HECTD1; ASB4; PDZRN3B; TRIM63; RNF144AB; RNF115
    ubiquitin protein ligase binding MC1R; TRIB1; TANK; CD40; FZD8; PRKAR1A; DAXX; LC3; LRPPRC; SKI
    ubiquitin-protein transferase activity RC3H2; TRIM69; RAG1; TRIM71; UBE2G1; UBE2H; UBE2E3; CBLL1; ARIH1L; CDC34
    contributes_to ubiquitin-protein transferase activity FBXL15; KBTBD13; KLHL17; KLHL10; KLHL41B; CUL3; BACH1; TCEB1B; KLHL42; KLHL33

    ube2c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2c here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2c.


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