USP7
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Official Full Name
ubiquitin specific peptidase 7 (herpes virus-associated)
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Overview
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004] -
Synonyms
USP7; ubiquitin specific peptidase 7 (herpes virus-associated); HAUSP, ubiquitin specific protease 7 (herpes virus associated); ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific protease 7 (herpes virus-associated); TEF1; HAUSP;
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- Involved Pathway
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- Interacting Protein
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USP7 involved in several pathways and played different roles in them. We selected most pathways USP7 participated on our site, such as FoxO signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | NLK2;STAT3;MAPK8A;GABARAPL1;CAT;SGK2B;GADD45BB;CDKN1BB;INSRB |
| Herpes simplex infection | HNRPK;TAF5;TAF4B;TNFB;PPP1CC;IFNA8;HLA-DRA;PPP1CB;NFKB1 |
USP7 has several biochemical functions, for example, ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP7 itself. We selected most functions USP7 had, and list some proteins which have the same functions with USP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease activity | USP33;TNFAIP3;OTUD7B;USP37;USP12A;BRCC3;OTUD7A;OTUB2;USP1 |
USP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP7.
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Customer Reviews (3)
Write a reviewThe product's widespread recognition among researchers made it a preferred choice for many scientific studies.
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Q&As (7)
Ask a questionYes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.
Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.
USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.
USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.
Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.
USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.
Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.
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