USP7

  • Official Full Name

    ubiquitin specific peptidase 7 (herpes virus-associated)

  • Overview

    Ubiquitin carboxyl-terminal hydrolase 7 (USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004]
  • Synonyms

    USP7; ubiquitin specific peptidase 7 (herpes virus-associated); HAUSP, ubiquitin specific protease 7 (herpes virus associated); ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific protease 7 (herpes virus-associated); TEF1; HAUSP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP7-490H Active Recombinant Human USP7 protein, His-tagged E.coli His
Human USP7-922H Active Recombinant Human USP7 protein, His-tagged Insect Cell His
Human USP7-925H Recombinant Human USP7 protein(Met1-Asn1102), His&GST-tagged Insect Cells N-His&GST Met1-Asn1102
Human USP7-924H Recombinant Human USP7 protein(Lys208-Glu560), His&GST-tagged Insect Cells N-His&GST Lys208-Glu560
Human USP7-926H Recombinant Human USP7 protein Insect Cells N/A Lys208-Glu560
Human USP7-319H Recombinant Human USP7 protein, GST-tagged E.coli GST
Human USP7-320H Recombinant Human USP7 protein, His-tagged E.coli His
Human USP7-29182TH Recombinant Human USP7, His-tagged E.coli His
Human USP7-671HCL Recombinant Human USP7 cell lysate Insect Cell N/A
Human USP7-672HCL Recombinant Human USP7 cell lysate Insect Cell N/A
Human CAB11623MH Mouse Monoclonal Antibody to Human Ubiquitin Specific Peptidase 7 Mouse N/A
Human USP7-0552H Recombinant Human USP7 Protein (K208-E560), His tagged E.coli His K208-E560
Human USP7-677H Recombinant Human USP7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human USP7-457H Recombinant Human USP7 protein, His-tagged E.coli His Glu68~Glu521
Human USP7-807HFL Recombinant Full Length Human USP7 Protein, C-Flag-tagged Mammalian cells Flag
Human USP710799H Recombinant Human USP7 (208-560) Protein
Human USP7-0553H Recombinant Human USP7 Protein (A2-T344), Tag Free Insect Cell No tag A2-T344
Human USP7-5967H Recombinant Human USP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human USP7-4717H Recombinant Human USP7 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 214-521aa
Human USP7-02H Recombinant Human USP7 Protein, His-tagged E.coli His
Human USP7-2329H Recombinant Human USP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human USP7-2329H-B Recombinant Human USP7 Protein Pre-coupled Magnetic Beads HEK293
Human USP7-6588H Recombinant Human USP7 Protein (Gly202-Asn1102), N-His tagged E.coli N-His Gly202-Asn1102
Mouse Usp7-6882M Recombinant Mouse Usp7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat USP7-6480R Recombinant Rat USP7 Protein Mammalian Cell His
Rat USP7-6136R Recombinant Rat USP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat USP7-6136R-B Recombinant Rat USP7 Protein Pre-coupled Magnetic Beads HEK293
Chicken USP7-6041C Recombinant Chicken USP7 Mammalian Cell His
CBCRY35 Ubiquitin Carboxyl-terminal Hydrolase 7 E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

USP7 involved in several pathways and played different roles in them. We selected most pathways USP7 participated on our site, such as FoxO signaling pathway, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayHRASB;HRASA;TGFB2;INS2;GRB2B;CCND1;CAT;NLK2;HRAS
Herpes simplex infectionCD74;IFNPHI3;MHC2A;POLR2A;STAT1B;HLA-DQB1;TAB2;UBE2R2;IFNG

USP7 has several biochemical functions, for example, ubiquitin-specific protease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USP7 itself. We selected most functions USP7 had, and list some proteins which have the same functions with USP7. You can find most of the proteins on our site.

Function Related Protein
ubiquitin-specific protease activityYOD1;ZRANB1;USP7;USP18;USP12A;ZRANB1B;USP51;USP1;OTUB1B

USP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP7.

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Does USP7 interact with specific protein substrates? 12/02/2022

Yes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.

Can USP7 inhibitors be potential cancer therapeutics? 08/04/2022

Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.

Does USP7 have tissue-specific expression patterns? 03/29/2021

USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.

What is the significance of USP7 in neurodegenerative diseases? 02/03/2020

USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.

Are there post-translational modifications of USP7? 06/17/2019

Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.

How does USP7 regulate the p53 pathway? 04/24/2018

USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.

Is USP7 involved in the immune response? 02/18/2018

Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.

Customer Reviews (3)

Write a review
Reviews
10/22/2021

    The product's widespread recognition among researchers made it a preferred choice for many scientific studies.

    06/17/2018

      Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.

      06/28/2016

        The product's respected reputation in the scientific community was a testament to its quality and effectiveness.

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