Ubiquitin Carboxyl-terminal Hydrolase 7

Cat.No. : CBCRY35
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Cat. No. : CBCRY35
Background : Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.
Protein Classification : Hydrolase
Structure Weight : 121067.00 Da
Polymer : 1
Molecule : Ubiquitin carboxyl-terminal hydrolase 7
Chain Length : 522 amino acids
MMDB ID : 37695
Source : E.coli
Method : X-Ray Diffraction
Resolution : 3.2Å
Reference : Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27
Gene Name : USP7
Synonyms : HAUSP; TEF1; EC; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific peptidase 7; ubiquitin specific protease 7 (herpes virus-associated); deubiquitinating enzyme 7; Ubiquitin thioesterase 7
UniProt ID : Q93009
Gene ID : 7874
Chromosome Location : 16p13.3
Function : cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; protein binding; protein C-terminus binding; peptidase activity; cysteine-type peptidase activity; hydrolase activity

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Q&As (7)

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Does USP7 interact with specific protein substrates? 12/02/2022

Yes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.

Can USP7 inhibitors be potential cancer therapeutics? 08/04/2022

Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.

Does USP7 have tissue-specific expression patterns? 03/29/2021

USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.

What is the significance of USP7 in neurodegenerative diseases? 02/03/2020

USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.

Are there post-translational modifications of USP7? 06/17/2019

Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.

How does USP7 regulate the p53 pathway? 04/24/2018

USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.

Is USP7 involved in the immune response? 02/18/2018

Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.

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