Ubiquitin Carboxyl-terminal Hydrolase 7
Cat.No. : | CBCRY35 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY35 |
Background : | Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway. |
Protein Classification : | Hydrolase |
Structure Weight : | 121067.00 Da |
Polymer : | 1 |
Molecule : | Ubiquitin carboxyl-terminal hydrolase 7 |
Chain Length : | 522 amino acids |
PDB ID : | 2F1Z |
MMDB ID : | 37695 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 3.2Å |
Reference : | Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27 |
Gene Name : | USP7 |
Synonyms : | HAUSP; TEF1; EC 3.1.2.15; Herpes virus-associated ubiquitin-specific protease; ubiquitin specific peptidase 7; ubiquitin specific protease 7 (herpes virus-associated); deubiquitinating enzyme 7; Ubiquitin thioesterase 7 |
UniProt ID : | Q93009 |
Gene ID : | 7874 |
Chromosome Location : | 16p13.3 |
Function : | cysteine-type endopeptidase activity; ubiquitin thiolesterase activity; protein binding; protein C-terminus binding; peptidase activity; cysteine-type peptidase activity; hydrolase activity |
Products Types
◆ Recombinant Protein | ||
USP7-0552H | Recombinant Human USP7 Protein (K208-E560), His tagged | +Inquiry |
USP7-925H | Recombinant Human USP7 protein(Met1-Asn1102), His&GST-tagged | +Inquiry |
USP7-677H | Recombinant Human USP7 Protein, MYC/DDK-tagged | +Inquiry |
USP7-0553H | Recombinant Human USP7 Protein (A2-T344), Tag Free | +Inquiry |
Usp7-6882M | Recombinant Mouse Usp7 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
USP7-672HCL | Recombinant Human USP7 cell lysate | +Inquiry |
USP7-671HCL | Recombinant Human USP7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.
Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.
USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.
USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.
Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.
USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.
Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.
Customer Reviews (3)
Write a reviewThe product's widespread recognition among researchers made it a preferred choice for many scientific studies.
Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.
The product's respected reputation in the scientific community was a testament to its quality and effectiveness.
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