Recombinant Human USP7 Protein, MYC/DDK-tagged
Cat.No. : | USP7-677H |
Product Overview : | Recombinant human USP7 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293. |
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Description : | The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016] |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol. |
Molecular Mass : | 128.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | ubiquitin specific peptidase 7[ Homo sapiens ] |
Official Symbol : | USP7 |
Synonyms : | HAUSP; TEF1 |
Gene ID : | 7874 |
mRNA Refseq : | NM_003470.2 |
Protein Refseq : | NP_003461.2 |
MIM : | 602519 |
UniProt ID : | Q93009 |
Products Types
◆ Recombinant Protein | ||
USP7-6136R | Recombinant Rat USP7 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP7-924H | Recombinant Human USP7 protein(Lys208-Glu560), His&GST-tagged | +Inquiry |
USP7-0553H | Recombinant Human USP7 Protein (A2-T344), Tag Free | +Inquiry |
USP7-0552H | Recombinant Human USP7 Protein (K208-E560), His tagged | +Inquiry |
Usp7-6882M | Recombinant Mouse Usp7 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
USP7-671HCL | Recombinant Human USP7 cell lysate | +Inquiry |
USP7-672HCL | Recombinant Human USP7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe product's widespread recognition among researchers made it a preferred choice for many scientific studies.
Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.
The product's respected reputation in the scientific community was a testament to its quality and effectiveness.
Q&As (7)
Ask a questionYes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.
Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.
USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.
USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.
Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.
USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.
Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.
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