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Recombinant Full Length Human USP7 Protein, C-Flag-tagged

Cat.No. : USP7-807HFL
Product Overview : Recombinant Full Length Human USP7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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  • Gene Information
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Description : The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 128.1 kDa
AA Sequence : MNHQQQQQQQKAGEQQLSEPEDMEM EAGDTDDPPRITQNPVINGNVALSD GHNTAEEDMEDDTSWRSEAT FQFTVERFSRLSESVLSPPCFVRNL PWKIMVMPRFYPDRPHQKSVGFFLQ CNAESDSTSWSCHAQAVLKI INYRDDEKSFSRRISHLFFHKENDW GFSNFMAWSEVTDPEKGFIDDDKVT FEVFVQADAPHGVAWDSKKH TGYVGLKNQGATCYMNSLLQTLFFT NQLRKAVYMMPTEGDDSSKSVPLAL QRVFYELQHSDKPVGTKKLT KSFGWETLDSFMQHDVQELCRVLLD NVENKMKGTCVEGTIPKLFRGKMVS YIQCKEVDYRSDRREDYYDI QLSIKGKKNIFESFVDYVAVEQLDG DNKYDAGEHGLQEAEKGVKFLTLPP VLHLQLMRFMYDPQTDQNIK INDRFEFPEQLPLDEFLQKTDPKDP ANYILHAVLVHSGDNHGGHYVVYLN PKGDGKWCKFDDDVVSRCTK EEAIEHNYGGHDDDLSVRHCTNAYM LVYIRESKLSEVLQAVTDHDIPQQL VERLQEEKRIEAQKRKERQE AHLYMQVQIVAEDQFCGHQGNDMYD EEKVKYTVFKVLKNSSLAEFVQSLS QTMGFPQDQIRLWPMQARSN GTKRPAMLDNEADGNKTMIELSDNE NPWTIFLETVDPELAASGATLPKFD KDHDVMLFLKMYDPKTRSLN YCGHIYTPISCKIRDLLPVMCDRAG FIQDTSLILYEEVKPNLTERIQDYD VSLDKALDELMDGDIIVFQK DDPENDNSELPTAKEYFRDLYHRVD VIFCDKTIPNDPGFVVTLSNRMNYF QVAKTVAQRLNTDPMLLQFF KSQGYRDGPGNPLRHNYEGTLRDLL QFFKPRQPKKLYYQQLKMKITDFEN RRSFKCIWLNSQFREEEITL YPDKHGCVRDLLEECKKAVELGEKA SGKLRLLEIVSYKIIGVHQEDELLE CLSPATSRTFRIEEIPLDQV DIDKENEMLVTVAHFHKEVFGTFGI PFLLRIHQGEHFREVMKRIQSLLDI QEKEFEKFKFAIVMMGRHQY
INEDEYEVNLKDFEPQPGNMSHPRP WLGLDHFNKAPKRSRYTYLEKAIKI HNTRTRPLEQKLISEEDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protease
Gene Name : USP7 ubiquitin specific peptidase 7 [ Homo sapiens (human) ]
Official Symbol : USP7
Synonyms : TEF1; HAUSP; HAFOUS
Gene ID : 7874
mRNA Refseq : NM_003470.3
Protein Refseq : NP_003461.2
MIM : 602519
UniProt ID : Q93009

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Does USP7 interact with specific protein substrates? 12/02/2022

Yes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.

Can USP7 inhibitors be potential cancer therapeutics? 08/04/2022

Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.

Does USP7 have tissue-specific expression patterns? 03/29/2021

USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.

What is the significance of USP7 in neurodegenerative diseases? 02/03/2020

USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.

Are there post-translational modifications of USP7? 06/17/2019

Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.

How does USP7 regulate the p53 pathway? 04/24/2018

USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.

Is USP7 involved in the immune response? 02/18/2018

Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.

Customer Reviews (3)

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Reviews
10/22/2021

    The product's widespread recognition among researchers made it a preferred choice for many scientific studies.

    06/17/2018

      Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.

      06/28/2016

        The product's respected reputation in the scientific community was a testament to its quality and effectiveness.

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