Recombinant Full Length Human USP7 Protein, C-Flag-tagged
Cat.No. : | USP7-807HFL |
Product Overview : | Recombinant Full Length Human USP7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 128.1 kDa |
AA Sequence : | MNHQQQQQQQKAGEQQLSEPEDMEM EAGDTDDPPRITQNPVINGNVALSD GHNTAEEDMEDDTSWRSEAT FQFTVERFSRLSESVLSPPCFVRNL PWKIMVMPRFYPDRPHQKSVGFFLQ CNAESDSTSWSCHAQAVLKI INYRDDEKSFSRRISHLFFHKENDW GFSNFMAWSEVTDPEKGFIDDDKVT FEVFVQADAPHGVAWDSKKH TGYVGLKNQGATCYMNSLLQTLFFT NQLRKAVYMMPTEGDDSSKSVPLAL QRVFYELQHSDKPVGTKKLT KSFGWETLDSFMQHDVQELCRVLLD NVENKMKGTCVEGTIPKLFRGKMVS YIQCKEVDYRSDRREDYYDI QLSIKGKKNIFESFVDYVAVEQLDG DNKYDAGEHGLQEAEKGVKFLTLPP VLHLQLMRFMYDPQTDQNIK INDRFEFPEQLPLDEFLQKTDPKDP ANYILHAVLVHSGDNHGGHYVVYLN PKGDGKWCKFDDDVVSRCTK EEAIEHNYGGHDDDLSVRHCTNAYM LVYIRESKLSEVLQAVTDHDIPQQL VERLQEEKRIEAQKRKERQE AHLYMQVQIVAEDQFCGHQGNDMYD EEKVKYTVFKVLKNSSLAEFVQSLS QTMGFPQDQIRLWPMQARSN GTKRPAMLDNEADGNKTMIELSDNE NPWTIFLETVDPELAASGATLPKFD KDHDVMLFLKMYDPKTRSLN YCGHIYTPISCKIRDLLPVMCDRAG FIQDTSLILYEEVKPNLTERIQDYD VSLDKALDELMDGDIIVFQK DDPENDNSELPTAKEYFRDLYHRVD VIFCDKTIPNDPGFVVTLSNRMNYF QVAKTVAQRLNTDPMLLQFF KSQGYRDGPGNPLRHNYEGTLRDLL QFFKPRQPKKLYYQQLKMKITDFEN RRSFKCIWLNSQFREEEITL YPDKHGCVRDLLEECKKAVELGEKA SGKLRLLEIVSYKIIGVHQEDELLE CLSPATSRTFRIEEIPLDQV DIDKENEMLVTVAHFHKEVFGTFGI PFLLRIHQGEHFREVMKRIQSLLDI QEKEFEKFKFAIVMMGRHQY INEDEYEVNLKDFEPQPGNMSHPRP WLGLDHFNKAPKRSRYTYLEKAIKI HNTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Protease |
Gene Name : | USP7 ubiquitin specific peptidase 7 [ Homo sapiens (human) ] |
Official Symbol : | USP7 |
Synonyms : | TEF1; HAUSP; HAFOUS |
Gene ID : | 7874 |
mRNA Refseq : | NM_003470.3 |
Protein Refseq : | NP_003461.2 |
MIM : | 602519 |
UniProt ID : | Q93009 |
Products Types
◆ Recombinant Protein | ||
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USP7-925H | Recombinant Human USP7 protein(Met1-Asn1102), His&GST-tagged | +Inquiry |
USP7-0552H | Recombinant Human USP7 Protein (K208-E560), His tagged | +Inquiry |
USP7-6136R | Recombinant Rat USP7 Protein, His (Fc)-Avi-tagged | +Inquiry |
USP7-0553H | Recombinant Human USP7 Protein (A2-T344), Tag Free | +Inquiry |
◆ Lysates | ||
USP7-672HCL | Recombinant Human USP7 cell lysate | +Inquiry |
USP7-671HCL | Recombinant Human USP7 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.
Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.
USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.
USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.
Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.
USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.
Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.
Customer Reviews (3)
Write a reviewThe product's widespread recognition among researchers made it a preferred choice for many scientific studies.
Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.
The product's respected reputation in the scientific community was a testament to its quality and effectiveness.
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