Recombinant Rat USP7 Protein, His (Fc)-Avi-tagged

• Cat.No.: USP7-6136R
• Product Overview: Recombinant Rat USP7 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Usp7 ubiquitin specific peptidase 7 (herpes virus-associated) [ Rattus norvegicus ]
• Official Symbol: USP7
• Gene ID: 360471
• mRNA Refseq: NM_001024790.1
• Protein Refseq: NP_001019961.1
• UniProt ID: Q4VSI4

Reviews

10/22/2021

The product's widespread recognition among researchers made it a preferred choice for many scientific studies.

06/17/2018

Positive feedback from other labs and researchers confirmed its standing as a valuable research tool.

06/28/2016

The product's respected reputation in the scientific community was a testament to its quality and effectiveness.

Q&As

Does USP7 interact with specific protein substrates?

Yes, USP7 interacts with various protein substrates, including p53, MDM2, and PTEN, influencing their stability and cellular functions.

Can USP7 inhibitors be potential cancer therapeutics?

Inhibitors targeting USP7 are being explored as potential cancer therapeutics, aiming to disrupt the stability of oncogenic proteins and inhibit cancer cell growth.

Does USP7 have tissue-specific expression patterns?

USP7 exhibits tissue-specific expression patterns, and its levels may vary in different tissues and cell types.

What is the significance of USP7 in neurodegenerative diseases?

USP7 has been implicated in neurodegenerative diseases, and its dysregulation may contribute to protein aggregation and neuronal dysfunction.

Are there post-translational modifications of USP7?

Yes, USP7 undergoes post-translational modifications, including phosphorylation and ubiquitination, which can regulate its activity and stability.

How does USP7 regulate the p53 pathway?

USP7 regulates the p53 pathway by deubiquitinating and stabilizing p53, preventing its degradation and promoting its transcriptional activity.

Is USP7 involved in the immune response?

Yes, USP7 plays a role in the immune response by regulating the stability of proteins involved in immune signaling pathways.