Recombinant Human USP7 Protein, His-tagged

• Cat.No.: USP7-02H
• Product Overview: Recombinant Human USP7 Protein, fused to His-tag, was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 50 mM HEPES pH 7.5, 150 mM sodium chloride, 2 mM dithiothreitol, 10% glycerol.
• Molecular Mass: ~130 kDa
• AA Sequence: MGSSHHHHHHSSG LEVLFQGP G S M N HQQQQQQQKAGEQQLSEPEDMEMEAGDTD DPPRITQNPVINGNVALSDGHNTAEEDMED DTSWRSEATFQFTVERFSRLSESVLSPP CFVRNLPWKIMVMPRFYPDRPHQKSVGF FLQCNAESDSTSWSCHAQAVLKIINYRD DEKSFSRRISHLFFHKENDWGFSNFMAWSEVT DPEKGFIDDDKVTFEVFVQADAPHGVAWDSK KHTGYVGLKNQGATCYMNSLLQTLFFTNQL RKAVYMMPTEGDDSSKSVPLALQRVFYELQHS DKPVGTKKLTKSFGWETLDSFMQHDVQEL CRVLLDNVENKMKGTCVEGTIPKLFRGKM VSYIQCKEVDYRSDRREDYYDIQLSIKGK KNIFESFVDYVAVEQLDGDNKYDAGEHGLQE AEKGVKFLTLPPVLHLQLMRFMYDPQTDQNI KINDRFEFPEQLPLDEFLQKTDPKDPANYIL HAVLVHSGDNHGGHYVVYLNPKGDGKW CKFDDDVVSRCTKEEAIEHNYGGHDDDLS VRHCTNAYMLVYIRESKLSEVLQAVTDHDI PQQLVERLQEEKRIEAQKRKERQEAHLYMQVQ IVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNS SLAEFVQSLSQTMGFPQDQIRLWPMQARSNGT KRPAMLDNEADGNKTMIELSDNENPWTIFLET VDPELAASGATLPKFDKDHDVMLFLKMYDPK TRSLNYCGHIYTPISCKIRDLLPVMCDRAG FIQDTSLILYEEVKPNLTERIQDYDVSLDKA LDELMDGDIIVFQKDDPENDNSELPTAKEY FRDLYHRVDVIFCDKTIPNDPGFVVTLSNRM NYFQVAKTVAQRLNTDPMLLQFFKSQGYRDG PGNPLRHNYEGTLRDLLQFFKPRQPKKLYY QQLKMKITDFENRRSFKCIWLNSQFREEEIT LYPDKHGCVRDLLEECKKAVELGEKASGKL RLLEIVSYKIIGVHQEDELLECLSPATSRT FRIEEIPLDQVDIDKENEMLVTVAHFHKEV FGTFGIPFLLRIHQGEHFREVMKRIQSLL DIQEKEFEKFKFAIVMTGRHQYINEDEYEVN LKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRY TYLEKAIKIHN
• Purity: >80%
• Storage: 12 months at -70 centigrade; aliquot as required.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: USP7 ubiquitin specific peptidase 7 [ Homo sapiens (human) ]
• Official Symbol: USP7
• Synonyms: TEF1; HAUSP; HAFOUS
• Gene ID: 7874
• mRNA Refseq: NM_001286457
• Protein Refseq: NP_001273386
• MIM: 602519
• UniProt ID: Q93009