VCL

  • Official Full Name

    vinculin

  • Overview

    Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms

    VCL; vinculin; MV; MVCL; CMD1W; CMH15; HEL114; metavinculin; epididymis luminal protein 114;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Human
  • Mouse
  • Rat
  • Turkey
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Turkey Smooth muscle
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VCL-7919H Recombinant Human VCL E.coli N/A
Human VCL-01H Recombinant Human VCL, His-tagged Human Cell His
Human VCL-68H Recombinant Human VCL, His tagged Human Cell His
Human VCL-230H Recombinant Human VCL protein E.coli N/A
Human VCL-3655H Recombinant Human VCL, His-tagged E.coli His N-term-376aa
Human VCL-1687HCL Recombinant Human VCL cell lysate Human Cell N/A
Human VCL-1302H Recombinant Human VCL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VCL-118H Recombinant Human VCL Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human VCL-3709H Recombinant Human VCL protein, GST-tagged E.coli GST 777-1066 aa
Human VCL-6549H Recombinant Human VCL Protein (Lys1020-Gln1134), N-His tagged E.coli N-His Lys1020-Gln1134
Human VCL-554H Recombinant Human VCL Protein, His-tagged E.coli N-His Val3-Arg485
Human VCL-5283H Recombinant Human VCL protein, GST-tagged E.coli GST 2-235aa
Human VCL-1871H Active Recombinant Human VCL protein, His-tagged HEK293 His Pro 2 - Gln 1066
Human VCL-2679H Recombinant Human VCL protein(311-430 aa), C-His-tagged E.coli C-His 311-430 aa
Mouse VCL-222M Recombinant Mouse Vcl, His tagged Human Cell His
Mouse Vcl-1869M Recombinant Mouse Vcl protein, His-tagged E.coli His Glu879~Trp1064
Mouse VCL-900MCL Recombinant Mouse VCL cell lysate Human Cell N/A
Mouse Vcl-6910M Recombinant Mouse Vcl Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat VCL-6507R Recombinant Rat VCL Protein Mammalian Cell His
Rat VCL-6163R Recombinant Rat VCL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VCL-6163R-B Recombinant Rat VCL Protein Pre-coupled Magnetic Beads HEK293
Turkey VCL-899T Native Turkey VCL Protein Turkey Smooth muscle N/A
Chicken VCL-6991C Recombinant Chicken VCL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

VCL involved in several pathways and played different roles in them. We selected most pathways VCL participated on our site, such as Focal adhesion, Adherens junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Focal adhesionPXNA;ACTB;THBS4B;VASPA;CAV3;MAPK3;ITGA8;CDC42L2;ILK
Adherens junctionACTN4;TGFBR1;ERBB2;PTPRFB;RHOAB;EGFR;NLK;PVRL2;SSX2IP
Leukocyte transendothelial migrationItgam&Itgb2;PECAM1;JAM3;ACTN3;CLDN18;RHOH;CDH5;NIPAL1;VAV2
Regulation of actin cytoskeletonPAK2A;MAPK1;MAPK3;RDX;FGF18;MYLPF;PXNA;MSN;PDGFB
Bacterial invasion of epithelial cellsPIK3CA;CTNNA3;CAV1;PIK3CD;SEPT3;DNM3;WASL;SEPT11;CBLC
ShigellosisMAPK12;SRC;WASF1;ROCK1;MAPK1;U2AF1;CD44;ITGA5;IL-8
AmoebiasisCOL4A1;TNF;RELA;PIK3R5;SERPINB13;COL4A4;PIK3R3;COL3A1;RAB7B

VCL has several biochemical functions, for example, actin binding, NOT actin binding, alpha-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VCL itself. We selected most functions VCL had, and list some proteins which have the same functions with VCL. You can find most of the proteins on our site.

Function Related Protein
actin bindingDIAPH3;FLII;MYHZ1.1;TNS4;DST;KIF18A;Fert2;MYRIP;SHROOM1
NOT actin binding
alpha-catenin bindingPKP3;PKP2;CTNNB1;CDH24;JUP;VCL;AJUBA;JUPA;JUB
beta-catenin bindingLZTS2A;HDAC6;LEF1;CARM1;NF2;PROP1;CTNNA1;CALCOCO1;C
cadherin bindingAKAP5;NUMB;CTNNAL1;P2RX4;VCL;CDH13;PTPRM;MMP24;FXYD5
dystroglycan bindingDAG1;MAP2;AGR2;VCL;GYLTL1B;AGR3;AGRN;DMD;CLASP1
protein bindingF2RL1;OAS1;RRP8;SCUBE3;MUC7;NRADD;NQO1;PTPN12;ITPKB
structural molecule activityKRT81;CLTB;KRT35;KRT18;TUBA1B;EIF3A;ASPH;KRT222;KRT71
ubiquitin protein ligase bindingMC1R;TOLLIP;NKD2;FZD8;HSPA1A;UBE2L3;GSK3B;RNF20;UBE2B

VCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCL here. Most of them are supplied by our site. Hope this information will be useful for your research of VCL.

ipaA; Sorbs1; ipaA; TEKT1; TRIP6; VCAM1; TLN1

Research Area

Related articles

Liu, BJ; Tang, M; et al. Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 33:142-150(2014).
Puard, V; Tranchant, T; et al. Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11:-(2013).
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