VPS4A

  • Official Full Name

    vacuolar protein sorting 4 homolog A (S. cerevisiae)

  • Overview

    The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
  • Synonyms

    VPS4A; vacuolar protein sorting 4 homolog A (S. cerevisiae); vacuolar protein sorting 4A (yeast homolog) , vacuolar protein sorting 4A (yeast); vacuolar protein sorting-associated protein 4A; FLJ22197; SKD1; SKD1A; SKD2; VPS4; VPS4 1; hVPS4; SKD1 homolog; SKD1-homolog; Vacuolar protein sorting 4 homolog A; vacuolar protein sorting 4A (yeast); vacuolar protein sorting factor 4A; Vacuolar protein sorting-associating protein 4A; vacuolar sorting protein 4; VPS4-1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VPS4A-1914HCL Recombinant Human VPS4A cell lysate N/A
Human VPS4A-3913H Recombinant Human VPS4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VPS4A-301457H Recombinant Human VPS4A protein, GST-tagged E.coli GST Lys86-Ser437
Human VPS4A-2343H Recombinant Human VPS4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VPS4A-1245HFL Recombinant Full Length Human VPS4A Protein, C-Flag-tagged Mammalian cells Flag
Human VPS4A-2343H-B Recombinant Human VPS4A Protein Pre-coupled Magnetic Beads HEK293
Mouse VPS4A-18380M Recombinant Mouse VPS4A Protein Mammalian Cell His
Mouse VPS4A-10072M Recombinant Mouse VPS4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse VPS4A-10072M-B Recombinant Mouse VPS4A Protein Pre-coupled Magnetic Beads HEK293
Mouse Vps4a-572M Recombinant Mouse Vps4a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat VPS4A-6545R Recombinant Rat VPS4A Protein Mammalian Cell His
Rat VPS4A-6201R-B Recombinant Rat VPS4A Protein Pre-coupled Magnetic Beads HEK293
Rat VPS4A-6201R Recombinant Rat VPS4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque VPS4A-5172R Recombinant Rhesus monkey VPS4A Protein, His-tagged Mammalian Cell His
Rhesus Macaque VPS4A-4985R Recombinant Rhesus Macaque VPS4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque VPS4A-4985R-B Recombinant Rhesus Macaque VPS4A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish VPS4A-4503Z Recombinant Zebrafish VPS4A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

VPS4A involved in several pathways and played different roles in them. We selected most pathways VPS4A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisDNM3;TGFBR1A;RAB22A;ERBB3B;FAM21C;EEA1;GRK1A;SH3GL1;HLA-E

VPS4A has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS4A itself. We selected most functions VPS4A had, and list some proteins which have the same functions with VPS4A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP13A4;MYH15;DYRK4;TTL;PRKCA;DDX28;MAP2K2A;MYO9B;ATP1A3B
ATPase activityDDX3X;ABCA4;ABCA6;ENTPD2;ABCB4;KIFC3;HSPD1;MYH8;EIF4A1A
ATPase activity, coupledHSPA6;ABCB1A;CCT8;PEX1;HSPA8;HSPA1A;HSPA1B;HSP104;MYO1E
NOT microtubule-severing ATPase activityVPS4B;VPS4A
protein C-terminus bindingIFT52;SDCBP;TAE1;MAP2K1;FIGN;STIP1;PXK;YWHAB;SLC9A3R2
protein bindingMYL12A;LGALS14;FAM161A;HPRT1;RAB5B;HER11;Serpina1b;CTAG2;ERP44
protein domain specific bindingVPS11;WNT3A;GSN;CALM;CALM2;ARFIP1;ERCC1;DIXDC1;RAPGEF3

VPS4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS4A here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS4A.

NFKB1; BABAM1; pi3p; CFTR; Smo; LRRK2; CENPQ; NABP2; TMEM248; TUBA1A; PDCD6IP

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