WDR1

  • Official Full Name

    WD repeat domain 1

  • Overview

    This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    WDR1;WD repeat domain 1;WD repeat-containing protein 1;Actin interacting protein 1;AIP1;D5Wsu185e;NORI 1;actin-interacting protein 1;NORI-1

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
  • GST
  • MBP
  • SUMO
  • DDK
  • Myc

    Involved Pathway

    WDR1 involved in several pathways and played different roles in them. We selected most pathways WDR1 participated on our site, such as Hemostasis,Hypertrophy Model,Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hypertrophy Model MSTNB,ZEB1B,IFRD1,MYOG,MSTN,DUSP14,ADAM10A,ANKRD1,CYR61,HBEGFB
    Platelet degranulation HRG,CALU,TFA,F13A1B,MMRN1,F13A1A.1,MMRN2A,CAP1,PLEK,SPARC
    Hemostasis KIFAP3,MMRN1,FCER1GL,ITGB3A,KIF3C,SLC7A8A,KIF2B,MMRN2A,DOCK2,CD177
    Platelet activation, signaling and aggregation SPARC,MMRN1,GNA13B,CAP1,CD9A,CLU,TFA,CLEC1B,GAS6,PLEK
    Response to elevated platelet cytosolic Ca2+ CALU,STXBP3A,SERPINF2B,STXBP3,MMRN1,SCG3,HRG,CD9A,TFA,SPARC

    Protein Function

    WDR1 has several biochemical functions, for example, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR1 itself. We selected most functions WDR1 had, and list some proteins which have the same functions with WDR1. You can find most of the proteins on our site.

    Function Related Protein
    actin binding ADD2,SHROOM3,INPPL1,BCL7B,CAPZA1A,ACTN3,ESPN,FSCN1A,INPPL1B,ALKBH4

    Interacting Protein

    WDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR1.

    GRB2;SRPK1;TNFRSF10D;CSNK2B;SKIV2L;q8clp4_yerpe;ere_dna;MYO1C;FLNA;MYH9;IQGAP1;CAPZA2;NUP107;Tpm1;PPP1CB;BIRC3;BIRC2

    Resources

    References

    • Izawa, S; Okamura, T; et al. Autoantibody against WD repeat domain 1 is a novel serological biomarker for screening of thyroid neoplasia. CLINICAL ENDOCRINOLOGY 79:35-42(2013).
    • Izawa, S; Taniguchi, S; et al. Anti-WDR1 Antibody: A Novel Biochemical Marker for the Differential Diagnosis of Thyroid Neoplasm.. ENDOCRINE REVIEWS 31:-(2010).

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