WDR1

  • Official Full Name

    WD repeat domain 1

  • Overview

    This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    WDR1; WD repeat domain 1; WD repeat-containing protein 1; Actin interacting protein 1; AIP1; D5Wsu185e; NORI 1; actin-interacting protein 1; NORI-1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WDR1-357HCL Recombinant Human WDR1 293 Cell Lysate HEK293 N/A
Human WDR1-1213H Recombinant Human WDR1 Protein (189-461 aa), GST-tagged E.coli GST 189-461 aa
Mouse WDR1-18449M Recombinant Mouse WDR1 Protein Mammalian Cell His
Mouse Wdr1-6972M Recombinant Mouse Wdr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse WDR1-10119M Recombinant Mouse WDR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WDR1-10119M-B Recombinant Mouse WDR1 Protein Pre-coupled Magnetic Beads HEK293
Rat WDR1-6564R Recombinant Rat WDR1 Protein Mammalian Cell His
Rat WDR1-6220R-B Recombinant Rat WDR1 Protein Pre-coupled Magnetic Beads HEK293
Rat WDR1-6220R Recombinant Rat WDR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish WDR1-11270Z Recombinant Zebrafish WDR1 Mammalian Cell His
Chicken WDR1-1220C Recombinant Chicken WDR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WDR1 Related Articles

WDR1 involved in several pathways and played different roles in them. We selected most pathways WDR1 participated on our site, such as Hemostasis, Hypertrophy Model, Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HemostasisNADL1.1;HBBE2;ABHD6B;TRPC7;CLU;PRKCHB;PDE10A;ATP2B1B;AKAP1
Hypertrophy ModelMSTNB;HBEGFB;DUSP14;JUND;ZEB1B;CYR61;WDR1;MYOG;MSTN
Platelet activation, signaling and aggregationMMRN2A;CD9A;SRGN;AASS;CALU;CD9B;RHOGA;C6orf25;F13A1B
Platelet degranulationF13A1A.1;AASS;CLU;SPARC;SRGN;MMRN1;SCG3;CAP1;SERPINF2B
Response to elevated platelet cytosolic Ca2+STXBP3A;PLEK;MMRN1;WDR1;CALU;SCG3;CAP1;SERPINF2B;TFA

WDR1 has several biochemical functions, for example, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR1 itself. We selected most functions WDR1 had, and list some proteins which have the same functions with WDR1. You can find most of the proteins on our site.

Function Related Protein
actin bindingSSH1;FLNC;CAPGA;EPB41;CAPZA2;PARVB;PACRG;WASL;MTAP1A

WDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR1.

GRB2; SRPK1; TNFRSF10D; CSNK2B; SKIV2L; q8clp4_yerpe; ere_dna; MYO1C; FLNA; MYH9; IQGAP1; CAPZA2; NUP107; Tpm1; PPP1CB; BIRC3; BIRC2

Izawa, S; Okamura, T; et al. Autoantibody against WD repeat domain 1 is a novel serological biomarker for screening of thyroid neoplasia. CLINICAL ENDOCRINOLOGY 79:35-42(2013).
Izawa, S; Taniguchi, S; et al. Anti-WDR1 Antibody: A Novel Biochemical Marker for the Differential Diagnosis of Thyroid Neoplasm.. ENDOCRINE REVIEWS 31:-(2010).
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