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Active Recombinant Human CA8 Protein, His-tagged

Cat.No. : CA8-397H
Product Overview : Recombinant human CA8 protein fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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Description : CA8 was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, this protein lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). It continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3).
Source : E.coli
Species : Human
Tag : His
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
Bio-activity : Specific activity is >450 pmol/min/ug, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH 7.5 at 37C.
Molecular Mass : 35.5 kDa (314aa), confirmed by MALDI-TOF(Molecular weight on SDS-PAGE will appear higher)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANG EYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVR FHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEIL QDIQYKGKSK TIPCFNPNTL LPDPLLRDYW VYEGSLTIPP CSEGVTWILF RYPLTISQLQ IEEFRRLRTH VKGAELVEGC DGILGDNFRP TQPLSDRVIR AAFQ
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : CA8 carbonic anhydrase VIII [ Homo sapiens ]
Official Symbol : CA8
Synonyms : CA8; carbonic anhydrase VIII; CALS; carbonic anhydrase-related protein; CARP; CA-related protein; carbonate dehydratase; carbonic anhydrase-like sequence; CAMRQ3; CA-VIII; MGC99509; MGC120502;
Gene ID : 767
mRNA Refseq : NM_004056
Protein Refseq : NP_004047
MIM : 114815
UniProt ID : P35219
Chromosome Location : 8q11-q12
Function : carbonate dehydratase activity; metal ion binding; zinc ion binding;

Not For Human Consumption!

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10/17/2021

    Saves time with efficient sample processing and analysis.

    09/18/2021

      Dedicated to our research success and achievements.

      08/02/2021

        Quick and precise protein quantification services.

        Q&As (7)

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        Are there specific proteins or molecules known to interact with CA8? 11/17/2021

        CA8 interacts with IP3Rs, affecting calcium signaling in neurons.

        How does CA8's role differ from the enzymatically active carbonic anhydrase isoforms? 07/10/2021

        Unlike enzymatically active isoforms, CA8 doesn't catalyze the hydration of CO2 but instead plays roles in neuronal signaling and function.

        Are there genetic mutations in the CA8 gene that are linked to specific diseases? 01/06/2020

        Mutations in CA8 have been linked to cerebellar ataxia, a movement disorder.

        How does CA8 contribute to cellular processes, given its non-enzymatic nature? 09/15/2019

        CA8 impacts calcium signaling in neurons, affecting neural communication and potentially influencing motor control.

        What post-translational modifications are typical for CA8? 05/23/2019

        Specific modifications, like phosphorylation, can be explored using mass spectrometry or targeted biochemical assays.

        What is the primary function of CA8, considering it's a non-enzymatic member of the carbonic anhydrase family? 12/02/2017

        CA8 acts as a stabilizer for inositol 1,4,5-trisphosphate receptors (IP3Rs) in neurons.

        In which human tissues or cell types is CA8 predominantly expressed? 04/18/2017

        CA8 is mainly expressed in the cerebellum, particularly in Purkinje cells.

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