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  • Official Full Name

    carbonic anhydrase VIII

  • Overview

    The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
  • Synonyms

    CA8; carbonic anhydrase VIII; CALS; CARP; CAMRQ3; CA-VIII; CAR8; carbonic anhydrase 8; ENSMUSG00000041261; wdl; Cals1; AW546993; 4 A1; 4 7.7 cM; carbonic anhydrase-related protein; CA-RP VIII; carbonic anhydrase-like sequence 1; EC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mouse
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA8-397H Active Recombinant Human CA8 Protein, His-tagged E.coli His
Human CA8-10626H Recombinant Human CA8, GST-tagged E.coli GST N-term-139a.a.
Human CA8-879H Active Recombinant Human CA8 protein, His-tagged E.coli His Met1-Gln290
Human CA8-1388H Recombinant Human Carbonic Anhydrase VIII, His-tagged E.coli His
Human CA8-813H Recombinant Human CA8 Protein E.coli N/A
Human CA8-0248H Recombinant Human CA8 Protein, GST-Tagged Wheat Germ GST
Human CA8-142HCL Recombinant Human CA8 lysate HEK293 N/A
Human CA8-2744HF Recombinant Full Length Human CA8 Protein, GST-tagged In Vitro Cell Free System GST 290 amino acids
Human CA8-2273H Recombinant Human CA8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA8-0231H Recombinant Human CA8 Protein (Met1-Gln290), N-His-tagged E.coli N-His Met1-Gln290
Human CA8-2618H Recombinant Human CA8 protein, GST-tagged E.coli GST 1-290aa
Human CA8-1683H Recombinant Human CA8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CA8-0824H Recombinant Human CA8 Protein (Ala2-Gln290), C-His tagged E.coli C-His Ala2-Gln290
Mouse Car8-1804M Active Recombinant Mouse Carbonic Anhydrase 8, His-tagged Mouse His
Mouse Car8-749M Recombinant Mouse Car8 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CAR8-1136R Recombinant Rat CAR8 Protein Mammalian Cell His
Rat CA8-721R-B Recombinant Rat CA8 Protein Pre-coupled Magnetic Beads HEK293
Rat CA8-721R Recombinant Rat CA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CA8-598R Recombinant Rhesus monkey CA8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CA8-426R-B Recombinant Rhesus Macaque CA8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CA8-426R Recombinant Rhesus Macaque CA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CA8-2350Z Recombinant Zebrafish CA8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CA8 involved in several pathways and played different roles in them. We selected most pathways CA8 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCA8;CA9;GLUD2;CA5B;CPS1;CAR5A;CAR3;GLULB;Car12

CA8 has several biochemical functions, for example, carbonate dehydratase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA8 itself. We selected most functions CA8 had, and list some proteins which have the same functions with CA8. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCar2;Car4;CA13;CAR7;CA7;CAHZ;CA2;CAR6;CA6

CA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA8.


  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there specific proteins or molecules known to interact with CA8? 11/17/2021

CA8 interacts with IP3Rs, affecting calcium signaling in neurons.

How does CA8's role differ from the enzymatically active carbonic anhydrase isoforms? 07/10/2021

Unlike enzymatically active isoforms, CA8 doesn't catalyze the hydration of CO2 but instead plays roles in neuronal signaling and function.

Are there genetic mutations in the CA8 gene that are linked to specific diseases? 01/06/2020

Mutations in CA8 have been linked to cerebellar ataxia, a movement disorder.

How does CA8 contribute to cellular processes, given its non-enzymatic nature? 09/15/2019

CA8 impacts calcium signaling in neurons, affecting neural communication and potentially influencing motor control.

What post-translational modifications are typical for CA8? 05/23/2019

Specific modifications, like phosphorylation, can be explored using mass spectrometry or targeted biochemical assays.

What is the primary function of CA8, considering it's a non-enzymatic member of the carbonic anhydrase family? 12/02/2017

CA8 acts as a stabilizer for inositol 1,4,5-trisphosphate receptors (IP3Rs) in neurons.

In which human tissues or cell types is CA8 predominantly expressed? 04/18/2017

CA8 is mainly expressed in the cerebellum, particularly in Purkinje cells.

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