CA8
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Official Full Name
carbonic anhydrase VIII
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Overview
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. -
Synonyms
CA8; carbonic anhydrase VIII; CALS; CARP; CAMRQ3; CA-VIII; CAR8; carbonic anhydrase 8; ENSMUSG00000041261; wdl; Cals1; AW546993; 4 A1; 4 7.7 cM; carbonic anhydrase-related protein; CA-RP VIII; carbonic anhydrase-like sequence 1; EC 4.2.1.1;
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- Mouse
- Wheat Germ
- GST
- His
- Fc
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- Non
- Involved Pathway
- Protein Function
- Interacting Protein
CA8 involved in several pathways and played different roles in them. We selected most pathways CA8 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CA4;CA4A;CA6;CA14;Car8;CA5B;CA5;CA3;GLUD1 |
CA8 has several biochemical functions, for example, carbonate dehydratase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA8 itself. We selected most functions CA8 had, and list some proteins which have the same functions with CA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CA12;CA15C;CAR13;CA13;CA15A;CA1;CA3;CA5;CA5B |
| protein binding | URI1;BARD1;SPCS1;GTF2F1;DPM1;BCL2L10;NME2;RINL;RAB3B |
| zinc ion binding | SUV39H2;ZFP622;RABGGTB;RNF20;TRIM52;ADAM15;PCGF1;BTR30;ADAM8A |
CA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA8.
TBX3; CRX; LNX1; SPDL1; HSD17B14; GGA2; MAGED1
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Q&As (7)
Ask a questionCA8 interacts with IP3Rs, affecting calcium signaling in neurons.
Unlike enzymatically active isoforms, CA8 doesn't catalyze the hydration of CO2 but instead plays roles in neuronal signaling and function.
Mutations in CA8 have been linked to cerebellar ataxia, a movement disorder.
CA8 impacts calcium signaling in neurons, affecting neural communication and potentially influencing motor control.
Specific modifications, like phosphorylation, can be explored using mass spectrometry or targeted biochemical assays.
CA8 acts as a stabilizer for inositol 1,4,5-trisphosphate receptors (IP3Rs) in neurons.
CA8 is mainly expressed in the cerebellum, particularly in Purkinje cells.
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