Active Recombinant Human CADM3, Fc-tagged, Biotinylated
|Product Overview :||The recombinant human NECL1-Fc fusion protein is expressed as a 535-amino acid protein consisting of Asn25 - Ala331 region of NECL1 (UniProt accession #Q8N126) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.|
- Gene Information
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|Source :||Human cells|
|Form :||Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).|
|Bio-activity :||Immobilized NECL1 protein supports the adhesion of C6 rat brain glial cells and enhances neurite outgrowth of E16-E18 rat embryonic cortical neurons|
|Molecular Mass :||Calculated molecular mass (kDa): 59.3; Estimated by SDS-PAGE under reducing condition (kDa): 60-70|
|AA Sequence :||NLSQDDSQPWTSDETVVAGGTVVLK CQVKDHEDSSLQWSNPAQQTLYFGE KRALRDNRIQLVTSTPHELSISIS NVALADEGEYTCSIFTMPVRTAKSL VTVLGIPQKPIITGYKSSLREKDTA TLNCQSSGSKPAARLTWRKGDQEL HGEPTRIQEDPNGKTFTVSSSVTFQ VTREDDGASIVCSVNHESLKGADRS TSQRIEVLYTPTAMIRPDPPHPRE GQKLLLHCEGRGNPVPQQYLWEKEG SVPPLKMTQESALIFPFLNKSDSGT YGCTATSNMGSYKAYYTLNVNDPS PVPSSSSTYHASTGTHTCPPCPAPE LLGGPSVFLFPPKPKDTLMISRTPE VTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVEW ESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK|
|Endotoxin :||<0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1>|
|Purity :||>95% judged by SDS-PAGE under reducing condition|
|Storage :||The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.|
|Gene Name :||CADM3 cell adhesion molecule 3 [ Homo sapiens ]|
|Official Symbol :||CADM3|
|Synonyms :||CADM3; cell adhesion molecule 3; IGSF4B, immunoglobulin superfamily, member 4B; BIgR; FLJ10698; Necl 1; NECL1; nectin like 1; SynCAM3; TSLL1; TSLC1-like 1; nectin-like 1; TSLC1-like protein 1; nectin-like protein 1; brain immunoglobulin receptor; synaptic cell adhesion molecule 3; immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Necl-1; synCAM3;|
|Gene ID :||57863|
|mRNA Refseq :||NM_001127173|
|Protein Refseq :||NP_001120645|
|UniProt ID :||Q8N126|
|Chromosome Location :||1q21.2-q22|
|Pathway :||Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Nectin/Necltrans heterodimerization, organism-specific biosystem;|
|Function :||protein homodimerization activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (5)Ask a question
Mutations or dysregulation of CADM3 have been linked to neurological disorders like autism spectrum disorders and schizophrenia, highlighting its significance in neural function.
CADM3 has extracellular domains responsible for adhesion. It interacts with other synaptic proteins like neurexins and neuroligins, contributing to synaptic adhesion and signaling.
CADM3 mediates synaptic adhesion and facilitates synaptic plasticity, which is essential for learning and memory processes. Understanding CADM3's role is critical for advancing our knowledge of neurological disorders and cognitive function.
CADM3, also known as SynCAM3, is a cell adhesion molecule that plays a crucial role in synapse formation and neural connectivity. It is primarily expressed in neural tissues, particularly in neurons.
CADM3 expression varies during brain development and contributes to neural differentiation and circuit formation, aiding in proper brain function.
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