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Active Recombinant Human CD33 protein, Fc-tagged

Cat.No. : CD33-0715H
Product Overview : Recombinant Human CD33 protein(Asp18-His259), fused with Fc tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human Siglec-3 Antibody at 1 μg/mL (100 μL/well) can bind Human Siglec-3, Fc Tag with a linear range of 0.2-2 ng/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminus.The protein has a calculated MW of 52.9 kDa. The protein migrates as 64-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Proteinlength : Asp18-His259
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.>90% as determined by SEC-MALS.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CD33 CD33 molecule [ Homo sapiens ]
Official Symbol : CD33
Synonyms : CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3;
Gene ID : 945
mRNA Refseq : NM_001082618
Protein Refseq : NP_001076087
MIM : 159590
UniProt ID : P20138

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the implications of CD33 polymorphisms in therapeutic targeting? 10/18/2022

Certain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.

What is the primary biological function of CD33 in hematopoietic cells? 10/08/2022

CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.

How does CD33 expression vary among different leukocyte populations? 01/11/2022

CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.

How has CD33 been utilized as a therapeutic target in hematological malignancies? 09/22/2021

CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.

How does CD33 signaling influence myeloid cell differentiation? 06/08/2020

While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.

What role does CD33 play in acute myeloid leukemia (AML)? 03/30/2019

CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.

Are there known ligands that bind specifically to CD33? 06/20/2018

The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.

Customer Reviews (3)

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Reviews
11/14/2019

    Quick dissolution, easy use.

    08/27/2019

      Excellent solubility, no aggregates.

      02/27/2019

        High concentration, very effective.

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