|Official Full Name||CD33 CD33 molecule|
|Background||CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC|
|Synonyms||CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Hematopoietic cell lineage||CD3D; IL2RA; GP9; CD22; GM2002; HLA-DRB3; HLA-DRB5; KIT; IL11RA2; CD7|
CD33 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.
|carbohydrate binding||REG3G; NCAN; CHI3L1; CLEC18B; LMAN2; REG3A; EMC7; G6PDX; Fcer2a; CLEC14A|
|protein binding||ITGA2B; C21orf7; DDA1; CRB1; ARIH2; ATP2B4; RASD1; BRD3; NME1; NLGN3|
|receptor activity||CHRM3; AMFR; TREM2; IL10RA; SLC20A2; CD244; CD226; TMEM123; EDAR; GRIK3|
CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.
PTPN6; PTPN11; KRT31; KRT40; HERC3