CD33

  • Official Full Name

    CD33 CD33 molecule

  • Overview

    CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC
  • Synonyms

    CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Rat
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • Avi
  • His
  • C
  • hFc
  • 6×His
  • mFc
  • DYKDDDDK
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • His|HIgG
  • SUMO
  • Myc
  • LIgG2b Fc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD33-176H Active Recombinant Human CD33, Fc Chimera Mammalian cells Fc Chimera
Human CD33-675H Active Recombinant Human CD33, Fc-tagged, Biotinylated Human Cell Fc
Human CD33-051H Active Recombinant Human CD33 protein, His-Avi-tagged, Biotinylated CHO cells His/Avi Met17-His259
Human CD33-25H Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor® 488 conjugated NS0 Fc
Human CD33-28H Active Recombinant Human CD33 Protein, Fc-tagged, Atto 647N conjugated NS0 Fc
Human CD33-26H Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor® 647 conjugated NS0 Fc
Human CD33-052H Active Recombinant Human CD33 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Met17-His259
Human CD33-27H Active Recombinant Human CD33 Protein, Fc-tagged, Atto 488 conjugated NS0 Fc
Human CD33-176HAF488 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human CD33-176HAF555 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human CD33-176HAF647 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human CD33-176HF Active Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human CD33-268H Active Recombinant Human CD33 protein, Avi-His-tagged, Biotinylated HEK293 Avi-His Asp 18 - His 259
Human CD33-0790H Recombinant Human CD33 Protein Wheat Germ N/A
Human CD33-7815H Active Recombinant Human CD33 protein, His-tagged HEK293 His Asp 18 - His 259
Human CD33-487H Recombinant Human CD33 molecule, His-tagged E.coli His
Human CD33-833H Recombinant Human CD33 Protein, Fc/His-tagged HEK293 Fc/His
Human CD33-313H Recombinant Human CD33, Fc tagged Human Cell N/A
Human CD33-10946H Recombinant Human CD33, GST-tagged E.coli GST 49-259a.a.
Human CD33-0791H Recombinant Human CD33 Protein, GST-Tagged Wheat Germ GST
Human CD33-234H Recombinant Human CD33, His tagged Human Cell Fc
Human CD33-459H Recombinant Human CD33 Molecule, Fc Chimera HEK293 Fc
Human CD33-5088H Recombinant Human CD33, His-tagged E.coli His
Human CD33-267H Recombinant Human CD33 protein, His-tagged HEK293 His 185
Human CD33-978HCL Recombinant Human CD33 cell lysate Human Cell N/A
Human CD33-313HF Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated HEK293 Fc 476
Human CD33-342H Active Recombinant Human CD33 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc Asp 18 - His 259
Human CD33-176HA Recombinant Human CD33 protein, Fc-tagged, APC labeled Mammalian cells Fc
Human CD33-3097H Recombinant Human CD33 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD33-313HAF555 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 476
Human CD33-240H Recombinant Human CD33 Protein, hIgG-His-tagged Insect Cell His/HIgG 18-259aa
Human CD33-459HA Recombinant Human CD33 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD33-2568H Recombinant Human CD33 protein, His-Avi-tagged HEK293 His-Avi It contains Asp18-His259 .
Human CD33-459HAF647 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD33-459HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD33-551H Recombinant Human CD33 Protein (Met1-His259) HEK293 N/A Met1-His259
Human CD33-234HAF555 Recombinant Human CD33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 253
Human CD33-176HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Human CD33-234HB Recombinant Human CD33 protein, His-tagged, Biotinylated HEK293 His
Human CD33-234HAF488 Recombinant Human CD33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 253
Human CD33-234HF Recombinant Human CD33 Protein, His-tagged, FITC conjugated HEK293 His 253
Human CD33-833HP Recombinant Human CD33 protein, Fc/His-tagged, R-PE labeled HEK293 Fc/His
Human CD33-552H Recombinant Human CD33 protein (Met1-His259) HEK293
Human CD33-313HAF488 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 476
Human CD33-29H Recombinant Human CD33 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Asp18-His259
Human CD33-833HA Recombinant Human CD33 protein, Fc/His-tagged, APC labeled HEK293 Fc/His
Human CD33-2662H Recombinant Human CD33 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 18-259aa
Human CD33-459HAF488 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human CD33-443H Recombinant Human CD33 Protein, His-tagged HEK293 His 364
Human CD33-013M CD33-coupled magnetic beads
Human CD33-833HAF488 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Human CD33-833HAF555 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Human CD33-0706H Active Recombinant Human CD33 protein, Fc-tagged HEK293 Fc Asp18-His259
Human CD33-031HG Active GMP Recombinant Human CD33 protein HEK293 DNA sequence encoding Human CD33(AAH28152.1) was expressed with His tag at the C-terminal.
Human CD33-459HAF555 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD33-833HAF647 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Human CD33-234HAF647 Recombinant Human CD33 protein, His-tagged, Alexa Fluor 647-Labeled HEK293 His Asp 18 - His 259
Human CD33-345H Recombinant Human CD33 protein, hFc-tagged HEK293 hFc It contains Asp18-His259.
Human CD33-313HAF647 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 476
Human CD33-833HF Recombinant Human CD33 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Human CD33-205H Recombinant Human CD33 Protein, His-tagged HEK293 His Thr142-Thr232
Human CD33-152H Recombinant Human CD33 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD33-444H Recombinant Human CD33 Protein, Fc-tagged HEK293 Fc 364
Human CD33-670H Recombinant Human CD33 Protein, His-tagged HEK293F N-His Asp18-His259
Human CD33-0710H Active Recombinant Human CD33 protein, Fc-tagged, FITC-Labeled HEK293 Fc Asp18-His259
Human CD33-139HFL Active Recombinant Full Length Human CD33 Protein, C-Flag-tagged Mammalian cells Flag
Human CD33-0712H Recombinant Human CD33 protein, Fc-tagged HEK293 Fc Pro18-His132
Human CD33-2933H Recombinant Human CD33 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD33-4673H Active Recombinant Human CD33 Protein, His-tagged, PE-Labeled HEK293 His Asp 18 - His 259
Human CD33-2680H Active Recombinant Human CD33 protein, hFc&His-tagged HEK293 hFc&His Asp18-His259
Human CD33-429M CD33 protein-coupled magnetic MicroBeads
Human CD33-3161HF Recombinant Full Length Human CD33 Protein In Vitro Cell Free System 836 amino acids
Human CD33-5833M Active CD33 protein-coupled magnetic Beads HEK293 Asp 18 - His 259
Human CD33-37H-B Recombinant Human CD33 Protein Pre-coupled Magnetic Beads HEK293
Human CD33-459HF Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD33-3162HF Recombinant Full Length Human CD33 Protein, GST-tagged In Vitro Cell Free System GST 364 amino acids
Human CD33-0704H Recombinant Human CD33 protein, His-tagged, APC-Labeled HEK293 His Asp18-His259
Human CD33-190H Recombinant Human CD33 Protein, His-tagged E.coli His
Human CD33-0709H Active Recombinant Human CD33 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Asp18-His259
Human CD33-37H Recombinant Human CD33 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD33-0711H Active Recombinant Human CD33 protein, His-tagged, FITC-Labeled HEK293 His Asp18-His259
Human CD33-0715H Active Recombinant Human CD33 protein, Fc-tagged HEK293 Fc Asp18-His259
Human CD33-5341H Recombinant Human CD33 Protein (Met1-His259), C-His tagged Mammalian cells C-His Met1-His259
Human CD33-501H Recombinant Human CD33 Protein (Asp18-His259), C-hFc and 6×His-tagged HEK293 C-hFc and 6×His Asp18-His259
Human CD33-043H Recombinant Human CD33 Protein, ECD, Tag Free, Biotinylated HEK293 Tag Free ECD
Human CD33-8465M Whole Blood CD33 protein-coupled magnetic MicroBeads
Human CD33-2357H Recombinant Human CD33 protein(Met1-His259), mFc-tagged HEK293 C-mFc Met1-His259
Mouse Cd33-6889M Recombinant Mouse CD33 Antigen, Fc-tagged Human Cell Fc 465aa
Mouse Cd33-586M Recombinant Mouse Cd33 protein, His-tagged E.coli His Asp18~Glu240
Mouse Cd33-5169M Recombinant Mouse Cd33 protein(Met1-Glu240), His-tagged HEK293 C-His Met1-Glu240
Mouse CD33-1808MCL Recombinant Mouse CD33 cell lysate Human Cell N/A
Mouse Cd33-6889MAF488 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 465
Mouse Cd33-832M Recombinant Mouse Cd33 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CD33-835M Recombinant Mouse CD33 Protein (Met1-Glu240) HEK293 N/A Met1-Glu240
Mouse CD33-0707M Recombinant Mouse CD33 protein, His-tagged HEK293 His Asp18-Glu240
Mouse Cd33-6889MAF647 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 465
Mouse Cd33-6889MA Recombinant Mouse Cd33 protein, Fc-tagged, APC labeled HEK293 Fc
Mouse Cd33-6889MP Recombinant Mouse Cd33 protein, Fc-tagged, R-PE labeled HEK293 Fc
Mouse Cd33-5169MAF647 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 235
Mouse Cd33-5169MAF555 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 235
Mouse Cd33-6889MAF555 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 465
Mouse Cd33-5169MF Recombinant Mouse Cd33 Protein, His-tagged, FITC conjugated HEK293 His 235
Mouse Cd33-5169MAF488 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 235
Mouse Cd33-6889MF Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, FITC conjugated HEK293 Fc 465
Rat Cd33-671R Recombinant Rat Cd33 Protein, His-tagged E.coli N-His Pro26-Cys298
Rat CD33-0705R Active Recombinant Rat CD33 protein, His-tagged HEK293 His Asp18-Gln240
Monkey CD33-181CAF488 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Gly248, 244
Monkey CD33-181CAF647 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Gly248, 244
Monkey CD33-181CAF555 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Gly248, 244
Monkey CD33-181CF Recombinant Cynomolgus CD33 Protein, His-tagged, FITC conjugated HEK293 His Met1-Gly248, 244
Cynomolgus CD33-0708C Recombinant Cynomolgus CD33 protein, His-tagged HEK293 His Met36-Leu248
Cynomolgus CD33-1081C Recombinant Cynomolgus CD33 Protein (Met1-Gly248), His-tagged, Biotinylated HEK293 His Met1-Gly248
Cynomolgus Monkey CD33-181C Recombinant Cynomolgus CD33, His-tagged Human Cell His Met1-Gly248
Homo sapiens (Human) RFL3999HF Recombinant Full Length Human Myeloid Cell Surface Antigen Cd33(Cd33) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-364)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageANPEP;CD3G;CD1E, B2M;ITGA5;Il4ra;IL6;CD2;DNTT;CD59

CD33 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingLGALS3L;LGALS9L1;CHODL;ZG16B;ASGR1;KLRC3;MAG;SIGLEC8;ILLR1
protein bindingGNA14;MRPS31;FBLIM1;PRELID1;CALML3;VAV2;CA1;KIF14;KRT15
receptor activityNOTCH2;RTN4RL1;CXCR3;GRIA3A;CADM3;CD200R4;PVRL3;P2RY11;ANTXR2B

CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.

PTPN6; PTPN11; KRT31; KRT40; HERC3

Research Area

Related articles

Loke, J; Khan, JN; et al. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. ANNALS OF HEMATOLOGY 94:361-373(2015).
Xu, LM; Zhang, Y; et al. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. INTERNATIONAL IMMUNOPHARMACOLOGY 24:463-473(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
11/14/2019

    Quick dissolution, easy use.

    08/27/2019

      Excellent solubility, no aggregates.

      02/27/2019

        High concentration, very effective.

        Q&As (7)

        Ask a question
        What are the implications of CD33 polymorphisms in therapeutic targeting? 10/18/2022

        Certain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.

        What is the primary biological function of CD33 in hematopoietic cells? 10/08/2022

        CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.

        How does CD33 expression vary among different leukocyte populations? 01/11/2022

        CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.

        How has CD33 been utilized as a therapeutic target in hematological malignancies? 09/22/2021

        CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.

        How does CD33 signaling influence myeloid cell differentiation? 06/08/2020

        While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.

        What role does CD33 play in acute myeloid leukemia (AML)? 03/30/2019

        CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.

        Are there known ligands that bind specifically to CD33? 06/20/2018

        The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.

        Ask a Question for All CD33 Products

        Required fields are marked with *

        My Review for All CD33 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends