CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC
CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hematopoietic cell lineage
Il6ra;IL7;IL3RA;IL11RA2;CD3D;CD44;IL11;KIT;CD3E
CD33 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.
CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.
Loke, J; Khan, JN; et al. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. ANNALS OF HEMATOLOGY 94:361-373(2015).
Xu, LM; Zhang, Y; et al. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. INTERNATIONAL IMMUNOPHARMACOLOGY 24:463-473(2015).
What are the implications of CD33 polymorphisms in therapeutic targeting?
10/18/2022
Certain polymorphisms in the CD33 gene can influence its expression on the cell surface, which might affect the efficacy of CD33-targeted therapies.
What is the primary biological function of CD33 in hematopoietic cells?
10/08/2022
CD33 is a transmembrane receptor primarily expressed on cells of myeloid lineage and is involved in modulating cellular functions, including the regulation of cellular proliferation and differentiation.
How does CD33 expression vary among different leukocyte populations?
01/11/2022
CD33 is predominantly expressed on myeloid cells, especially on immature myeloid cells. Its expression decreases as these cells differentiate and is typically low or absent on lymphoid cells.
How has CD33 been utilized as a therapeutic target in hematological malignancies?
09/22/2021
CD33 has been targeted for therapeutic antibodies in AML. An example is gemtuzumab ozogamicin, which targets CD33 and delivers a cytotoxic agent specifically to leukemia cells expressing CD33.
How does CD33 signaling influence myeloid cell differentiation?
06/08/2020
While the exact signaling pathways of CD33 are still under investigation, it is believed that CD33 signaling can influence the differentiation and function of myeloid cells, potentially playing a role in immune regulation.
What role does CD33 play in acute myeloid leukemia (AML)?
03/30/2019
CD33 is commonly expressed on the surface of AML blasts, making it a potential target for therapeutic interventions in AML.
Are there known ligands that bind specifically to CD33?
06/20/2018
The specific ligands for CD33 are not fully characterized, but it is believed to play a role in cell-cell interactions within the immune system.
