cd33
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  • Official Full Name
  • CD33 CD33 molecule
  • Background
  • CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC
  • Synonyms
  • CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3
Cat.#:CD33-176HATag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human CD33 protein, Fc-tagged, APC labeled
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Cat.#:CD33-176HPTag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human CD33 protein, Fc-tagged, R-PE labeled
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Cat.#:CD33-459HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 protein, Fc-tagged, APC labeled
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Cat.#:CD33-459HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 protein, Fc-tagged, R-PE labeled
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Cat.#:Cd33-6889MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd33 protein, Fc-tagged, APC labeled
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Cat.#:Cd33-6889MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd33 protein, Fc-tagged, R-PE labeled
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Cat.#:CD33-833HATag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 protein, Fc/His-tagged, APC labeled
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Cat.#:CD33-833HPTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 protein, Fc/His-tagged, R-PE labeled
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Cat.#:CD33-0790HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD33 Protein
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Cat.#:CD33-0791HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD33 Protein, GST-Tagged
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Cat.#:CD33-240HTag:HIgG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CD33 Protein, hIgG-His-tagged
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Cat.#:CD33-3097HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 Protein, MYC/DDK-tagged
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Cat.#:CD33-459HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 Molecule, Fc Chimera
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Cat.#:CD33-10946HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD33, GST-tagged
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Cat.#:CD33-176HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CD33, Fc Chimera
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Cat.#:CD33-234HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33, His tagged
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Cat.#:CD33-267HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33, His-tagged, Biotinylated
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Cat.#:CD33-268HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 Protein, His & Avi-tagged, Biotinylated
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Cat.#:CD33-313HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33, Fc tagged
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Cat.#:CD33-487HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD33 molecule, His-tagged
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Cat.#:CD33-5088HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD33, His-tagged
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Cat.#:CD33-675HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD33, Fc-tagged, Biotinylated
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Cat.#:CD33-7815HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 protein, His-tagged
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Cat.#:CD33-833HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CD33 Protein, Fc/His-tagged
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Cat.#:Cd33-5169MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd33, His tagged
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Cat.#:Cd33-586MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd33 protein, His-tagged
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Cat.#:Cd33-6889MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD33 Antigen, Fc-tagged
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Cat.#:CD33-181CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD33, His-tagged
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Cat.#:CD33-978HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD33 cell lysate
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Cat.#:CD33-1808MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD33 cell lysate
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Involved Pathway

CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hematopoietic cell lineage
CD36; IL3RA; Kitl; MME; HLA-DRB4; CSF3; Flt3l; CD8B1; FLT3; CSF3R

Protein Function

CD33 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein CLEC5A; LGALSLB; SIGLEC9; CHI3L2; KLRB1F; NOMO1; CLEC2D; VCAN; FCNA; LGALS9C
Function protein binding
Related Protein SPSB3; CSNK1D; MOS; SNX27; AICDA; ST8SIA5; CRYBB1; NUTF2; POLRMT; ATM
Function receptor activity
Related Protein CSF2RA; RTN4RL1; KIR2DL1; AGER; SV2A; GABRA5; VMN1R48; KLRK1; CD200R2; CADM1A

Interacting Protein

CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.
PTPN6; PTPN11; KRT31; KRT40; HERC3

CD33 Related Articles

Loke, J; Khan, JN; et al. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. ANNALS OF HEMATOLOGY 94:361-373(2015).
Xu, LM; Zhang, Y; et al. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. INTERNATIONAL IMMUNOPHARMACOLOGY 24:463-473(2015).