Active Recombinant Human CD3E protein, mFc-tagged

Cat.No. : CD3E-3082H
Product Overview : Recombinant Human CD3E protein(Asp 23-Asp 126), fused with mFc tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : mFc
Form : Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human CD3 epsilon, Mouse IgG2a Fc Tag at 1 μg/mL (100 μL/well) can bind Mouse Anti-Human CD3 (SP34-2) (mouse IgG1) with a linear range of 9.8-39 ng/mL.
Molecular Mass : This protein carries a mouse IgG2a Fc tag at the C-terminus.The protein has a calculated MW of 38.6 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Asp 23-Asp 126
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.>90% as determined by SEC-MALS.
Storage : For long term storage, the product should be stored at lyophilized state at-20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after storage at:-20°C to-70°C for 12 months in lyophilized state;-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Homo sapiens ]
Official Symbol : CD3E
Synonyms : CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683;
Gene ID : 916
mRNA Refseq : NM_000733
Protein Refseq : NP_000724
UniProt ID : P07766

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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03/22/2023

    Manufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.

    09/12/2021

      bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.

      06/17/2018

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.

        Q&As (5)

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        Can CD3E be used to assess the effectiveness of cancer immunotherapies? 04/07/2021

        Yes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.

        Are there any CD3E-targeted therapies? 06/01/2017

        There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.

        Are there any ongoing clinical trials involving CD3E? 12/20/2016

        There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.

        Can CD3E levels be used to monitor the progression of HIV? 08/27/2016

        Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.

        How is CD3E used in allergy diagnostics? 06/22/2016

        CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.

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