Active Recombinant Human CLEC12A Protein (Thr67-Ala265), N-hFc tagged

Cat.No. : CLEC12A-20H
Product Overview : Recombinant Human CLEC12A Protein (Thr67-Ala265) with a Human IgG1 (Pro100-Lys330) Fc tag at N-terminus was expressed in Chinese Hamster Ovary cell line.
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Description : This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Source : CHO
Species : Human
Tag : Fc
Form : Disulfide-linked homodimer
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Human Integrin alpha X beta 2 Protein is immobilized at 5.00 μg/mL, 100 μL/well, the concentration of Recombinant Human MICL/CLEC12A Fc Chimera that produces 50 % of the optimal binding response is approximately 1.20-12.0 μg/mL.
Molecular Mass : Predicted Molecular Mass: 50 kDa
SDS-PAGE: 70-85 kDa, under reducing conditions
Protein length : Thr67-Ala265
N-terminal Sequence Analysis : Met
Endotoxin : < 0.10 EU/μg of the protein by the LAL method.
Purity : > 90 %, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution : Reconstitute at 500 μg/mL in PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : CLEC12A C-type lectin domain family 12 member A [ Homo sapiens (human) ]
Official Symbol : CLEC12A
Synonyms : CLEC12A; C-type lectin domain family 12 member A; CLL1; MICL; CD371; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor
Gene ID : 160364
mRNA Refseq : NM_201623
Protein Refseq : NP_963917
MIM : 612088
UniProt ID : Q5QGZ9

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