Active Recombinant Human CSF2 Protein

• Cat.No.: CSF2-46H
• Product Overview: Recombinant Human CSF2 Protein without tag was expressed in E. coli.

Specification

• Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF promotes immune system development and regulates neutrophil function during infection. Human and mouse GM-CSF show no cross-reactivity.
• Source: E. coli
• Species: Human
• Bio-activity: TF-1 cell proliferation, ≤200 pg/mL; ≥5.0 x 10^6 units/mg
• Molecular Mass: Monomer, 14.6 kDa (128 aa)
• AA Sequence: MAPARSPSPSTQPWEHVNAIQEARR LLNLSRDTAAEMNETVEVISEMFDL QEPTCLQTRLELYKQGLRGSLTKLK GPLTMMASHYKQHCPPTPETSCATQ IITFESFKENLKDFLLVIPFDCWEP VQE
• Endotoxin: ≤1 EUs/μg, Kinetic LAL
• Purity: ≥95%, Reducing and Non-Reducing SDS PAGE
• Stability: 12 months from date of receipt when stored at -20 to -80 centigrade as supplied.
  1 month when stored at 4 centigrade after reconstituting as directed.
  3 months when stored at -20 to -80 centigrade after reconstituting as directed.
• Storage: Storage Prior to Reconstitution: -20 centigrade
• Storage Buffer: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
• Reconstitution: Sterile water at 0.1 mg/mL
• Shipping: Room temperature
• Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.

Gene Information

• Gene Name: CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens (human) ]
• Official Symbol: CSF2
• Synonyms: CSF2; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897
• Gene ID: 1437
• mRNA Refseq: NM_000758
• Protein Refseq: NP_000749
• MIM: 138960
• UniProt ID: P04141

Reviews

01/15/2022

The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

07/27/2021

The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

05/19/2019

Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

Q&As

How conserved is the sequence of CSF2 among different species?

The sequence of CSF2 is moderately conserved across different species.

What is the typical length of CSF2?

The length of CSF2 protein varies but is typically around 144 amino acids.

What is the main biological function of CSF2?

The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

In what tissues or cells is CSF2 commonly expressed?

CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

What does CSF2 stand for?

CSF2 stands for Colony Stimulating Factor 2.

Is CSF2 associated with any specific diseases or conditions?

CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

Which cellular functions are associated with CSF2?

CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.