csf2
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  • Official Full Name
  • colony stimulating factor 2 (granulocyte-macrophage)
  • Background
  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
  • Synonyms
  • CSF2; colony stimulating factor 2 (granulocyte-macrophage); GMCSF; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; granulocyte-macrophage colony-stimulating-factor; GM-CSF
Cat.#:CSF2-210HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSF2 Protein, non-tagged, Biotinylated
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Cat.#:CSF2-1968HTag:
Source (Host):PlantsSpecies:Human
Product nameRecombinant Human CSF2 Protein
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Cat.#:CSF2-1969HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CSF2 Protein, GST-tagged
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Cat.#:CSF2-3350HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSF2 Protein, MYC/DDK-tagged
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Cat.#:Csf2-4346RTag:
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat Csf2 Protein
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Cat.#:CSF2-4343OTag:
Source (Host):YeastSpecies:Ovine
Product nameRecombinant Ovine CSF2 Protein
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Cat.#:CSF2-4386FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline CSF2 Protein
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Cat.#:Csf2-303MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Colony Stimulating Factor 2 (Granulocyte-Macrophage)
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Cat.#:CSF2-03HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Granulocyte Macrophage Colony Stimulating Factor
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Cat.#:CSF2-85HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GMCSF, His-tagged
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Cat.#:CSF2-93PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine CSF2
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Cat.#:CSF2-143HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human CSF2, His-tagged
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Cat.#:CSF2-1552HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human CSF2, Active, His-tagged
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Cat.#:CSF2-220HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSF2, StrepII-tagged
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Cat.#:CSF2-22HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CSF2
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Cat.#:CSF2-23HTag:
Source (Host):RiceSpecies:Human
Product nameRecombinant Human CSF2
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Cat.#:CSF2-27473THTag:
Source (Host):Species:Human
Product nameRecombinant Human CSF2
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Cat.#:CSF2-27474THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSF2, His-tagged
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Cat.#:CSF2-453HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human CSF2 protein, His-tagged
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Cat.#:CSF2-467HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSF2
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Cat.#:CSF2-486HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSF2, Fc tagged
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Cat.#:CSF2-785HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSF2 protein, His & GST-tagged
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Cat.#:CSF2-87HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSF2, His-tagged
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Cat.#:CSF2-88HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human CSF2, His tagged
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Cat.#:CSF2-937HTag:
Source (Host):Pichia PastorisSpecies:Human
Product nameRecombinant Human CSF2 Protein
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Cat.#:CSF2-95HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human GM-CSF
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Cat.#:GSF2-110HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSF2
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Cat.#:Csf2-223MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Csf2 protein, His/S-tagged
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Cat.#:CSF2-327MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Csf2, His tagged
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Cat.#:CSF2-347MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Csf2, Fc tagged
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Cat.#:Csf2-507MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Csf2
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Cat.#:Csf2-539MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Csf2 protein, His & GST-tagged
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Cat.#:Csf2-9789MTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Csf2
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Cat.#:CSF2-294RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Csf2, His tagged
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Cat.#:Csf2-553RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Csf2, Fc-tagged
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Cat.#:Csf2-786RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Csf2 protein, His & GST-tagged
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Cat.#:Csf2-8907RTag:
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Csf2
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Cat.#:Csf2-94RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Csf2
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Cat.#:CSF2-1050RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CSF2 Protein, His-tagged
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Cat.#:Csf2-94CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine GM-CSF
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Cat.#:CSF2-79BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine GM-CSF
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Cat.#:CSF2-16CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken CSF2 protein
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Cat.#:CSF2-1729CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CSF2
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Cat.#:CSF2-106STag:
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine CSF2
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Cat.#:CSF2-231FTag:Met
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline CSF2, Met-tagged
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Cat.#:CSF2-025ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSF2 (18 - 144aa)
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Cat.#:GM-CSF-368ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine GM-CSF
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Cat.#:CSF2-646HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Colony Stimulating Factor 2 (Granulocyte-Macrophage)
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Cat.#:CSF2-648CTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Colony Stimulating Factor 2 (Granulocyte-Macrophage)
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Cat.#:CSF2-383HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage), His-tagged
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Cat.#:CSF2-470HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:Csf2-370MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:CSF2-360RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:CSF2-375BTag:N/A
Source (Host):HEK293TSpecies:Bovine
Product nameRecombinant Bovine Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:CSF2-374PTag:N/A
Source (Host):HEK293TSpecies:Pig
Product nameRecombinant Pig Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:CSF2-382MTag:N/A
Source (Host):E. coliSpecies:Monkey
Product nameRecombinant Monkey Colony Stimulating Factor 2 (granulocyte-macrophage)
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Cat.#:CSF2-86HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Colony Stimulating Factor 2(Granulocyte-macrophage)
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Cat.#:CSF2-3008HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CSF2 cell lysate
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Cat.#:CSF2-1008MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CSF2 cell lysate
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Cat.#:CSF2-740RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CSF2 cell lysate
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Cat.#:CSF2-149HGTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human CSF2 Protein
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Cat.#:CSF2-4341HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human CSF2 protein
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Cat.#:CSF2-P035HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CSF2 therapeutic protein
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Cat.#:CSC-TP040Tag:
Source (Host):CHOSpecies:Human
Product nameHuman CSF2 Stable Cell Line-CHO
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Cat.#:CSC-TP075Tag:
Source (Host):YeastSpecies:Human
Product nameHuman CSF2 Stable Cell Line-Yeast
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Cat.#:CSC-P0458Tag:
Source (Host):Species:
Product nameAnti-Human CSF2 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0459Tag:
Source (Host):Species:
Product nameAnti-Human CSF2 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0460Tag:
Source (Host):Species:
Product nameAnti-Human CSF2 scFv Stable Cell Line-CHO
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Involved Pathway

Csf2 involved in several pathways and played different roles in them. We selected most pathways Csf2 participated on our site, such as ARMS-mediated activation, Amoebiasis, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Csf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
LAMTOR2; PAQR3B; FGF8B; RASGRP4; SPTBN2; JAK3; DUSP7; PSME3; NETO2; CSF2RA
Amoebiasis
TLR4; LAMA2; PIK3CG; GM-CSF; COL27A1; CSF2; LAMB3; GNA11; IFNG; CD1d1
Axon guidance
SHB; DPYSL2B; DNM2; PSPN; ACTR2; EPHA2A; SCN8A; EPHA8; SCN3B; KLB
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IRF4; CTLA4; DGKA; BATF3; POU2F1; CDK4; IKZF1; EGR1; EGR2; CSF2
Calcium signaling in the CD4+ TCR pathway
JUNB; FKBP1A; RCAN2; POU2F1; CSF2; RCAN1; CHP; BATF3; AKAP5
Cytokine Signaling in Immune system
TRIM8; IFITM3; EIF4A1; TRIM5; DUSP9; TRIM48; XAF1; ADAR; NUP35; CSF2RA
Cytokine-cytokine receptor interaction
CCL2; CCR8; CCL20A.3; BMPR1AB; TNFSF12; BMPR1BA; KDR; IL18RAP; IL9R; PDGFRB
Cytokines and Inflammatory Response
CSF3; CSF2; CSF1

Protein Function

Csf2 has several biochemical functions, for example, cytokine activity, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Csf2 itself. We selected most functions Csf2 had, and list some proteins which have the same functions with Csf2. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein TNFSF13B; IFNB; CMTM4; TSLP; IL10; BMP10; BMP7; BMP7A; CCL19A.1; IFNPHI3
Function granulocyte macrophage colony-stimulating factor receptor binding
Related Protein CSF2
Function growth factor activity
Related Protein FGF8; FGF13A; TYMP; GDF10; JAG1; LEP; GRN; PRL2C3; IL8L2; FGF8B
Function protein binding
Related Protein ULK1; SMAD3B; NFKBIB; H2-AA; SAMD4A; CCDC155; APOE; AKAP7; SMCO3; KLHL38

Interacting Protein

Csf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Csf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Csf2.
MEOX2; CSF2RB; CSF2RA

Csf2 Related Articles

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).