Csf2

  • Official Full Name

    colony stimulating factor 2 (granulocyte-macrophage)

  • Overview

    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
  • Synonyms

    CSF2; colony stimulating factor 2 (granulocyte-macrophage); GMCSF; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; granulocyte-macrophage colony-stimulating-factor; GM-CSF;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Chicken
  • Equine
  • Feline
  • Human
  • Monkey
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Sheep
  • Canine
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Nicotiana Benthamiana
  • P. pastoris
  • P.pastoris
  • Plants
  • Rice
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(N
  • ter)
  • Myc
  • His|GST
  • His|S
  • SUMO
  • Met
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • hFc
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSF2-646H Active Recombinant Human Colony Stimulating Factor 2 (Granulocyte-Macrophage) Human N/A
Human CSF2-025E Active Recombinant Human CSF2 (18 - 144aa) E.coli N/A
Human CSF2-470H Active Recombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage) E.coli N/A
Human CSF2-648C Active Recombinant Colony Stimulating Factor 2 (Granulocyte-Macrophage) Canine N/A
Human CSF2-23H Active Recombinant Human CSF2 Rice N/A
Human CSF2-88H Active Recombinant Human CSF2, His tagged, Animal Free Nicotiana Benthamiana His
Human CSF2-467H Active Recombinant Human CSF2 E.coli His
Human CSF2-937H Active Recombinant Human CSF2 Protein P.pastoris N/A
Human CSF2-22H Active Recombinant Human CSF2 CHO N/A
Human GSF2-110H Active Recombinant Human GSF2 E.coli N/A
Human CSF2-143H Active Recombinant Human CSF2, His-tagged, Animal Free Nicotiana Benthamiana His
Human CSF2-95H Active Recombinant Human GM-CSF Yeast N/A
Human GM-CSF-01HG Active GMP Recombinant Human GM-CSF Protein CHO-K1
Human CSF2-145HG Active GMP Recombinant Human CSF2 protein E.coli N/A
Human CSF2-220H Recombinant Human CSF2, StrepII-tagged Human Cell Strep II 18-144, 127 a.a.
Human CSF2-1552H Recombinant human CSF2, Active, His-tagged Nicotiana Benthamiana His
Human CSF2-85H Recombinant Human GMCSF, His-tagged E.coli His
Human CSF2-1968H Active Recombinant Human CSF2 Protein Plants N/A
Human CSF2-383H Recombinant Human Colony Stimulating Factor 2 (granulocyte-macrophage), His-tagged Insect Cell His
Human CSF2-486H Recombinant Human CSF2 protein(Ala18-Glu144), hFc-tagged HEK293 N-hFc Ala18-Glu144
Human CSF2-27474TH Recombinant Human CSF2, His-tagged E.coli His
Human CSF2-87H Recombinant Human CSF2, His-tagged Insect Cell His
Human CSF2-86H Recombinant Human Colony Stimulating Factor 2(Granulocyte-macrophage) P.pastoris N/A
Human CSF2-03H Active Recombinant Human CSF2 protein E.coli N/A 127aa
Human CSF2-27473TH Recombinant Human CSF2 N/A
Human CSF2-453H Recombinant Human CSF2 protein, His-tagged HEK293F His Ala18~Glu144
Human CSF2-515H Recombinant Human CSF2 protein HEK293 127
Human CSF2-785H Recombinant Human CSF2 protein, His & GST-tagged E.coli His/GST Ala18~Glu144
Human CSF2-1969H Recombinant Human CSF2 Protein, GST-tagged Wheat Germ GST
Human CSF2-3008HCL Recombinant Human CSF2 cell lysate Human Cell N/A
Human CSF2-P035H Recombinant Human CSF2 therapeutic protein Yeast N/A 127 aa
Human CSF2-110H Recombinant Human CSF2 protein E.coli N/A 127
Human CSF2-4341HG GMP Recombinant Human CSF2 protein E.coli N/A 127
Human CSF2-46H Active Recombinant Human CSF2 Protein E.coli
Human CSF2-149HG Active GMP Recombinant Human CSF2 Protein HEK293
Human CSF2-142HG Active GMP Recombinant Human CSF2 protein HEK293
Human CSF2-2419H Recombinant Human CSF2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CSF2-142H Active Recombinant Human CSF2 Protein P.pastoris
Human CSF2-3350H Recombinant Human CSF2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSF2-2740H Recombinant Human CSF2 protein, GST-tagged E.coli GST 18-144aa
Human CSF2-211H Recombinant Human CSF2 Protein, His-tagged, Biotinylated HEK293 His Met1-Asn190
Human CSF2-158H Recombinant Human CSF2 Protein, His-tagged Human Cell His Ala18-Glu144
Human CSF2-210H Recombinant Human CSF2 Protein, non-tagged, Biotinylated HEK293 N/A
Human CSF2-116C Active Recombinant Human CSF2 Protein (128 aa) E.coli 128
Human CSF2-2739H Recombinant Human CSF2 protein, His-SUMO-tagged E.coli His-SUMO 18-144aa
Human CSF2-082H Recombinant Human CSF2 protein, His-tagged E.coli His 134aa
Human CSF2-632H Recombinant Human CSF2 Protein HEK293 N/A Ala18-Glu144
Human CSF2-31HG Active Recombinant Human CSF2 Protein (Ala18-Glu144), GMP Grade, Animal-Free E.coli Ala18-Glu144
Human CSF2-48H Recombinant Active Human CSF2 Protein, His-tagged(N-ter) E.coli His(N-ter)
Human CSF2-154C Active Recombinant Human CSF2 Protein P. pastoris
Human CSF2-040H Recombinant Human CSF2 Protein 144
Human CSF2-4034H Recombinant Human CSF2 Protein (Met1-Glu144), C-His tagged Mammalian cells C-His Met1-Glu144
Human CSF2-92H Human Granulocyte Macrophage Colony Stimulating Factor (rDNA derived) Reference standard N/A
Human CSF2-155C Active Recombinant Human CSF2 Protein P. pastoris
Human CSF2-492H Recombinant Human CSF2 Protein, Biotinylated 144
Human CSF2-608H Active Recombinant Human CSF2 Protein E.coli Tag Free
Human CSF2-17H Active Recombinant Human CSF2 Protein, Animal Free Human cells
Human CSF2-5385H Recombinant Human CSF2 protein, His-tagged Yeast His 18-144aa
Human CSF2-493H Recombinant Human CSF2 Protein 144
Human CSF2-2157HF Recombinant Full Length Human CSF2 Protein, GST-tagged In Vitro Cell Free System GST 144 amino acids
Human CSF2-135H Active Recombinant Human CSF2 Protein E.coli Ala18-Glu144
Human CSF2-2628H Active Recombinant Human CSF2 protein, His-tagged HEK293 His Ala18-Glu144
Human CSF2-276C Active Recombinant Human CSF2 Protein CHO
Human CSF2-392C Active Recombinant Human CSF2 Protein E.coli
Human CSF2-1827H Recombinant Human CSF2 Protein (Ala18-Glu144), C-His tagged E.coli C-His Ala18-Glu144
Human CSF2-2522H Recombinant Human CSF2 Protein (Ala18-Glu144), C-His tagged Mammalian cells C-His Ala18-Glu144
Human CSF2-28H Active Recombinant Human CSF2 Protein (Ala18-Glu144), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala18-Glu144
Human CSF2-2539H Recombinant Human CSF2 protein(18-144 aa), N-SUMO & C-His-tagged E.coli N-SUMO & C-His 18-144 aa
Mouse Csf2-9789M Active Recombinant Mouse Csf2 CHO N/A
Mouse Csf2-01M Active GMP Recombinant Mouse Csf2 Protein, His-Tagged E.coli His
Mouse CSF2-2384M Recombinant Mouse CSF2 protein(Ala18-Lys141), hFc-tagged HEK293 N-hFc Ala18-Lys141
Mouse CSF2-327M Active Recombinant Mouse CSF2 protein, His-tagged HEK293 His Ala18-Lys141
Mouse Csf2-223M Recombinant Mouse Csf2 protein, His/S-tagged E.coli His/S
Mouse Csf2-539M Recombinant Mouse Csf2 protein, His & GST-tagged E.coli His/GST Pro19~Lys141
Mouse Csf2-507M Recombinant Mouse Csf2 protein(Met1-Lys141) HEK293 N/A Met1-Lys141
Mouse CSF2-347M Recombinant Mouse Csf2, Fc tagged Human Cell N/A
Mouse Csf2-370M Recombinant Mouse Colony Stimulating Factor 2 (granulocyte-macrophage) Mouse N/A
Mouse Csf2-303M Recombinant Mouse Csf2 protein E.coli N/A 124
Mouse CSF2-1008MCL Recombinant Mouse CSF2 cell lysate Human Cell N/A
Mouse Csf2-275C Active Recombinant Mouse Csf2 Protein CHO
Mouse Csf2-044M Recombinant Mouse Csf2 Protein E.coli
Mouse Csf2-391C Active Recombinant Mouse Csf2 Protein (125 aa) E.coli 125
Mouse Csf2-321MG Active GMP Recombinant Mouse Csf2 protein HEK293 DNA sequence encoding Mouse GM-CSF(NP_034099.2) was expressed with His tag at the C-terminal.
Mouse Csf2-49M Recombinant Active Mouse CSF2 Protein, His-tagged(N-ter) E.coli His(N-ter)
Mouse Csf2-939M Active Recombinant Mouse Csf2 Protein E.coli
Mouse CSF2-47M Active Recombinant Mouse CSF2 Protein E.coli
Mouse Csf2-7180M Recombinant Mouse Csf2 Protein E.coli 18-141
Mouse Csf2-045M Active Recombinant Mouse Csf2 Protein E.coli
Mouse Csf2-7177M Recombinant Mouse Csf2 Protein E.coli
Mouse Csf2-940M Recombinant Mouse Csf2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Csf2-113M Mouse Granulocyte Macrophage Colony Stimulating Factor (rDNA derived) Reference standard N/A
Mouse Csf2-5629M Recombinant Mouse Csf2 Protein (Ala18-Lys141), C-His tagged Mammalian cells C-His Ala18-Lys141
Mouse Csf2-19M Active Recombinant Mouse Csf2 Protein (Ala18-Lys141), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala18-Lys141
Mouse Csf2-609M Active Recombinant Mouse Csf2 Protein E.coli Tag Free
Mouse Csf2-1509M Recombinant Mouse Csf2 protein HEK293 N/A Ala18-Lys141
Mouse Csf2-033C Active Recombinant Mouse Csf2 Protein (124 aa) E.coli 124
Rat Csf2-8907R Active Recombinant Rat Csf2 CHO N/A
Rat Csf2-786R Recombinant Rat Csf2 protein, His & GST-tagged E.coli His/GST Ala18~Lys144 (Accession # P48750)
Rat Csf2-553R Active Recombinant Rat Csf2 protein(Ala18-Lys144), hFc-tagged HEK293 N-hFc Ala18-Lys144
Rat CSF2-294R Recombinant Rat CSF2 protein(Ala18-Lys144), His-tagged HEK293 N-His Ala18-Lys144
Rat Csf2-94R Recombinant Rat Csf2 protein E.coli N/A 127
Rat CSF2-740RCL Recombinant Rat CSF2 cell lysate Human Cell N/A
Rat Csf2-1285R Recombinant Rat Csf2 Protein, His-tagged E.coli N-His Ala18-Lys144
Rat CSF2-48R Active Recombinant Rat CSF2 Protein E.coli
Rat Csf2-4346R Recombinant Rat Csf2 Protein Yeast N/A 127aa
Rat Csf2-274C Active Recombinant Rat Csf2 Protein CHO
Rat Csf2-012C Active Recombinant Rat Csf2 Protein (128 aa) E.coli 128
Monkey CSF2-382M Recombinant Monkey Colony Stimulating Factor 2 (granulocyte-macrophage) E.coli N/A
Bovine CSF2-79B Active Recombinant Bovine GM-CSF Yeast N/A
Bovine CSF2-375B Recombinant Bovine Colony Stimulating Factor 2 (granulocyte-macrophage) HEK293T N/A
Bovine CSF2-038B Recombinant Bovine CSF2 protein, His-Myc-tagged Yeast His/Myc 18-143aa
Canine Csf2-94C Active Recombinant Canine GM-CSF Yeast N/A
Canine CSF2-43C Active Recombinant Canine CSF2 Protein E.coli
Canine CSF2-467C Recombinant Canine CSF2 protein E.coli N/A 127
Equine GM-CSF-368E Recombinant Equine GM-CSF Yeast N/A
Feline CSF2-231F Active Recombinant Feline CSF2, Met-tagged E.coli Met
Feline CSF2-4386F Recombinant Feline CSF2 Protein Yeast N/A 127aa
Ovine CSF2-4343O Recombinant Ovine CSF2 Protein Yeast N/A 127aa
Porcine CSF2-01P Active GMP Recombinant Porcine CSF2 Protein, His-Tagged E.coli His
Porcine CSF2-44P Active Recombinant Porcine CSF2 Protein E.coli
Porcine CSF2-45P Active Recombinant Porcine CSF2 Protein E.coli
Rhesus CSF2-360R Recombinant Rhesus CSF2 protein E.coli N/A 127
Rhesus Macaque CSF2-1050R Recombinant Rhesus monkey CSF2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CSF2-875R Recombinant Rhesus Macaque CSF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CSF2-875R-B Recombinant Rhesus Macaque CSF2 Protein Pre-coupled Magnetic Beads HEK293
Sheep CSF2-2735S Recombinant Sheep CSF2 Protein, His&GST-tagged E.coli N-His&GST Ala18-Lys144
Pig CSF2-374P Recombinant Pig Colony Stimulating Factor 2 (granulocyte-macrophage) HEK293T N/A
Pig CSF2-106S Recombinant Swine CSF2 Yeast N/A
Pig CSF2-93P Recombinant Porcine CSF2 E.coli N/A
Pig CSF2-207P Active Recombinant Pig CSF2 Protein (Ala18-Lys144), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala18-Lys144
Pig CSF2-50P Recombinant Active Pig CSF2 Protein, His-tagged(N-ter) E.coli His(N-ter)
Chicken CSF2-16C Recombinant Chicken CSF2 protein Yeast N/A
Chicken CSF2-1729C Recombinant Chicken CSF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Csf2 involved in several pathways and played different roles in them. We selected most pathways Csf2 participated on our site, such as ARMS-mediated activation, Amoebiasis, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Csf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationSPTBN1;JAK3;SLC14A2;DUSP9;RASGRP1;DUSP5;NTF7;SPNA2;KIDINS220B
AmoebiasisCSF2;NOS2;PIK3CB;GNAS;COL27A1;PIK3R1;TGFB1;SERPINB2;PIK3CA
Axon guidanceSEMA3D;CFL1;HRAS;FGFR1B;ITGB3A;GPC1A;NRTN;AKAP9;SEMA6B
Calcineurin-regulated NFAT-dependent transcription in lymphocytesBATF3;POU2F1;EGR1;DGKA;EGR4;IRF4;CSF2;EGR3;CDK4
Calcium signaling in the CD4+ TCR pathwayAKAP5;RCAN1;BATF3;CHP;POU2F1;FKBP1A;RCAN2;CSF2;JUNB
Cytokine Signaling in Immune systemNUP35;TRIM22;DAB2IPB;EIF4EB;EIF4A2;NUP50;ADAR;JAK3;ISG20
Cytokine-cytokine receptor interactionIFNA14;TNFRSF19;GM-CSF;CCL3L1;CCL4L1;LEPB;Kitl;PDGFRB;FLT3LG
Cytokines and Inflammatory ResponseCSF2;CSF1;CSF3

Csf2 has several biochemical functions, for example, cytokine activity, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Csf2 itself. We selected most functions Csf2 had, and list some proteins which have the same functions with Csf2. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTNFSF13B;IFNW1;INHBAA;Gm13290;CD70;IL20;IL37;GRN;IFNA7
granulocyte macrophage colony-stimulating factor receptor binding
growth factor activitySPAW;FGF6B;CSPG5;IL9;WISP3;FGF1A;PSPN;OSGIN1;MDK
protein bindingCD200R1;RNF11;ZNF423;UPF3B;UBD;CD79A;PSMD3;SPTA1;GPI1

Csf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Csf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Csf2.

MEOX2; CSF2RB; CSF2RA

Research Area

Related articles

Schneider, C; Nobs, SP; et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLOS PATHOGENS 10:-(2014).
Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How conserved is the sequence of CSF2 among different species? 05/15/2021

The sequence of CSF2 is moderately conserved across different species.

What is the typical length of CSF2? 01/30/2021

The length of CSF2 protein varies but is typically around 144 amino acids.

What is the main biological function of CSF2? 05/01/2019

The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

In what tissues or cells is CSF2 commonly expressed? 02/03/2019

CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

What does CSF2 stand for? 07/10/2018

CSF2 stands for Colony Stimulating Factor 2.

Is CSF2 associated with any specific diseases or conditions? 03/17/2018

CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

Which cellular functions are associated with CSF2? 02/20/2017

CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.

Customer Reviews (3)

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Reviews
01/15/2022

    The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

    07/27/2021

      The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

      05/19/2019

        Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

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