| Official Full Name | colony stimulating factor 2 (granulocyte-macrophage) |
| Background | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
| Synonyms | CSF2; colony stimulating factor 2 (granulocyte-macrophage); GMCSF; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; granulocyte-macrophage colony-stimulating-factor; GM-CSF |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
Csf2 involved in several pathways and played different roles in them. We selected most pathways Csf2 participated on our site, such as ARMS-mediated activation, Amoebiasis, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Csf2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | SPRED2; NRG2A; SPRED1; IL17RD; SPTBN1; AKAP9; KIDINS220B; PHB; KBTBD7; FGF10B |
| Amoebiasis | FN1; SERPINB9; SERPINB4; ACTN1; LAMB1; LAMA4; TLR4; PIK3R2; COL1A1; PLCB2 |
| Axon guidance | CNKSR1; DUSP9; AKAP9; COL4A5; COL6A2; SEMA6D; EFNA3; CXCR4; SCN4A; CDK5 |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | DGKA; EGR3; CDK4; CTLA4; IKZF1; CSF2; EGR4; EGR1; BATF3; IRF4 |
| Calcium signaling in the CD4+ TCR pathway | BATF3; RCAN1; RCAN2; JUNB; CSF2; POU2F1; AKAP5; FKBP1A; CHP |
| Cytokine Signaling in Immune system | IFI6; CRK; FRS2B; TRIM31; PRLRB; IRAK3; GBP4; ADAR; PAQR3B; CASPB |
| Cytokine-cytokine receptor interaction | KITB; IL29; CRLF2; IL9; CCL21B; CXCR5; IRX1; TP-1; CCR7; INHBC |
| Cytokines and Inflammatory Response | CSF2; CSF3; CSF1 |
Csf2 has several biochemical functions, for example, cytokine activity, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Csf2 itself. We selected most functions Csf2 had, and list some proteins which have the same functions with Csf2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFN-a; Cxcl15; IL1A; BMP6; AREG; TNFSF12; LEFTY1; IL7; CSF1B; IL1F10 |
| granulocyte macrophage colony-stimulating factor receptor binding | CSF2 |
| growth factor activity | FGF7; IL9; IGF2B; FGF18A; PDGFC; GSDF; IL4; CNTF; IGF2A; IGF2 |
| protein binding | UFL1; RABL2A; KIF4A; NEFM; PPP1R15B; C15orf23; RPL10A; SMR3B; NME7; DHX9 |
Csf2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Csf2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Csf2.
MEOX2; CSF2RB; CSF2RA
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