IGFBP2
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Official Full Name
insulin-like growth factor binding protein 2, 36kDa
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Overview
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. -
Synonyms
IGFBP2; insulin-like growth factor binding protein 2, 36kDa; IBP2; IGF-BP53; insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Bovine
- Cattle
- Chicken
- Cynomolgus Monkey
- Gly33-Gln325
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- C-His
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Insect Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- yeast
- Fc
- Flag
- FLAG
- His
- Avi
- GST
- S
- T7
- Myc
- DDK
- Non
- Background
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- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
What is IGFBP2 protein?
IGFBP2 (insulin like growth factor binding protein 2) is a protein coding gene which situated on the long arm of chromosome 2 at locus 2q35. The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. The IGFBP2 protein is consisted of 325 amino acids and its molecular mass is approximately 34.8 kDa.
What is the function of IGFBP2 protein?
IGFBP2 can bind to insulin-like growth factor (IGF) to regulate the activity of IGF thus reducing the effect of IGF on cell proliferation and differentiation. Their interaction can activate caspase enzyme family and induce cell apoptosis; also it can activate MAPK signaling pathway, thus promoting cell movement and migration. In addition, it can activate the PI3K/Akt signaling pathway, thus promoting cell proliferation and differentiation.
IGFBP2 related Signaling pathways
The signaling pathways of IGFBP2 can be divided into IGFS-dependent and IGFS-independent. In the IGFS-dependent form, IGF binds to IGF1R to activate the intracellular IGF signaling pathway. In IGFS-independent forms, IGFBP2 interacts with ligands other than IGFs to regulate transcription, induces apoptosis and repairs DNA damage. For example, IGFBP2 acts synergistically with β-catenin signaling pathway to regulate the occurrence and development of tumors. Or participates in MAPK/ERK signaling pathway and PI3K/AKT/mTOR signaling pathway.
IGFBP2 Related Diseases
IGFBP2 inhibits the effects of IGF on cell proliferation and differentiation, so IGFBP2 expression is often reduced in cancer. Dysfunctional IGFBP2 also affects insulin regulation and the proliferation, differentiation or migration of some important cells, leading to diabetes, cardiovascular disease and obesity.
Fig1. High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway.
Bioapplications of IGFBP2
IGFBP2 is a protein that has diverse bioapplications, ranging from cancer to growth and development, diabetes, neurological disorders, and metabolic disorders. Further research is needed to fully understand its mechanisms of action and exploit its therapeutic potential, understanding the involvement of IGFBP2 in these diseases can contribute to the development of novel diagnostic and therapeutic strategies.
High Purity
Fig1. SDS-PAGE (IGFBP2-824H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (IGFBP2-02H)
Case Study 1: Feng Ling, 2023
Fig1. High expression of circadian rhythms (CR)-related genes was associated with Diabetic retinopathy (DR).
Case Study 2: Muhammad Sufyan Bin Masroni, 2023
Fig2. Immunoblotting to detect CCL28 and IGFBP2 in conditioned medium from mimic (Left) or pcDNA™6.2-GW/EmGFP-miR-125b plasmid (Right)-transfected MCF7 cells.
IGFBP2 involved in several pathways and played different roles in them. We selected most pathways IGFBP2 participated on our site, such as Metabolism of proteins, Myometrial Relaxation and Contraction Pathways, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with IGFBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | PAPPA;SCMH1;CNIH;TIMM22;IGFALS;TRAPPC9;GPR116;GALNTL2;WIPI1 |
| Myometrial Relaxation and Contraction Pathways | GUCA2A;GPR182;PKIB;IGFBP5;RGS20;MAFF;RXFP2;ATF5;RGS19 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | IGFBP5A;IGFBP2B;IGFBP6;IGFBP6B;IGF2B;GZMH;KLK13;IGFBP2;PAPPAB |
IGFBP2 has several biochemical functions, for example, insulin-like growth factor I binding, insulin-like growth factor II binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGFBP2 itself. We selected most functions IGFBP2 had, and list some proteins which have the same functions with IGFBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin-like growth factor I binding | IGFBP6;IGFBP6A;IGFBP3;IGFBP5;IGFBP5B;IGFBP2B;INSR;IGFBP1A;IGFBP1B |
| insulin-like growth factor II binding | IGFBP1A;IGFBP1B;IGFBP6;IGFBP6A;IGFBP5;IGFBP2A;IGFBP6B;IGFBP5B;INSR |
| protein binding | TXNL4B;SZL;NFIL3;CDHR1;CD2AP;COPS5;STX8;NGF;RNF216 |
IGFBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGFBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGFBP2.
INO80B; aroP; GSDMB
Research Area
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Customer Reviews (3)
Write a reviewWhether it's protein quantification, structural analysis, or Western Blotting, the IGFBP2 protein has consistently delivered exceptional results, earning my highest recommendation.
The IGFBP2 protein has proven invaluable in protein electron microscopy structure analysis, allowing for detailed investigations and providing critical insights.
Its remarkable performance in ELISA, protein electron microscopy structure analysis, and Western Blotting sets it apart as a top recommendation.
Q&As (5)
Ask a questionIGFBP2 levels can be measured using various laboratory techniques, including ELISA (Enzyme-Linked Immunosorbent Assay) and Western blotting.
Yes, IGFBP2 has been implicated in neurological disorders and metabolic diseases, making it a potential target for therapeutic interventions in these conditions.
Genetic variations in the IGFBP2 gene have been identified and may contribute to individual differences in disease susceptibility and treatment responses.
IGFBP2 binds to insulin-like growth factors, regulating their bioavailability and modulating their effects on cell growth and survival.
Research suggests that elevated levels of IGFBP2 may serve as a diagnostic marker for early cancer detection, but more studies are needed to validate its clinical utility.
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